LIAROZOLE DIHYDROCHLORIDE
- Product Name
- LIAROZOLE DIHYDROCHLORIDE
- CAS No.
- 1883548-96-6
- Chemical Name
- LIAROZOLE DIHYDROCHLORIDE
- Synonyms
- R75251 dihydrochloride;LIAROZOLE DIHYDROCHLORIDE;Liarozole dihydrochloride >=98% (HPLC)
- CBNumber
- CB04740469
- Molecular Formula
- C17H14Cl2N4
- Formula Weight
- 345.23
- MOL File
- 1883548-96-6.mol
LIAROZOLE DIHYDROCHLORIDE Property
- storage temp.
- room temp
- solubility
- Water: ≥ 50 mg/mL (131.00 mM); DMSO: 50 mg/mL (131.00 mM)
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 2mg/mL, clear
N-Bromosuccinimide Price
- Product number
- 2705
- Product name
- Liarozole dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CS-0033188
- Product name
- Liarozole dihydrochloride
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
LIAROZOLE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Biological Activity
Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) th at targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyase (CYP17A1), 11-hydroxylase (CYP11B1), and RA 4-hydroxylase (CYP26). Liarozole is more effective than ketoconazole in vivo (plasma RA enhancement = 2.5 ng/mL vs. 1.3 ng/mL 2 hr after respective oral dosage of 40 mg/kg in rats) and, in contrast to ketoconazole, Liarozole does not significantly affect circulating adrenal androgen levels. Liarozole is shown to effectively suppress androgen-dependent tumor expansion of R3327G Dunning prostate adenocarcinoma xenografts in rats (by 66% and 81% with 80 and 120 mg/kg/day p.o., respectively) independent of its androgen biosynthesis inhibition.
storage
Desiccate at RT