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LIAROZOLE DIHYDROCHLORIDE

Product Name
LIAROZOLE DIHYDROCHLORIDE
CAS No.
1883548-96-6
Chemical Name
LIAROZOLE DIHYDROCHLORIDE
Synonyms
R75251 dihydrochloride;LIAROZOLE DIHYDROCHLORIDE;Liarozole dihydrochloride >=98% (HPLC)
CBNumber
CB04740469
Molecular Formula
C17H14Cl2N4
Formula Weight
345.23
MOL File
1883548-96-6.mol
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LIAROZOLE DIHYDROCHLORIDE Property

storage temp. 
room temp
solubility 
Water: ≥ 50 mg/mL (131.00 mM); DMSO: 50 mg/mL (131.00 mM)
form 
powder
color 
white to beige
Water Solubility 
H2O: 2mg/mL, clear
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2705
Product name
Liarozole dihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$205
Updated
2021/12/16
ChemScene
Product number
CS-0033188
Product name
Liarozole dihydrochloride
Purity
≥99.0%
Packaging
5mg
Price
$280
Updated
2021/12/16
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LIAROZOLE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) th at targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyase (CYP17A1), 11-hydroxylase (CYP11B1), and RA 4-hydroxylase (CYP26). Liarozole is more effective than ketoconazole in vivo (plasma RA enhancement = 2.5 ng/mL vs. 1.3 ng/mL 2 hr after respective oral dosage of 40 mg/kg in rats) and, in contrast to ketoconazole, Liarozole does not significantly affect circulating adrenal androgen levels. Liarozole is shown to effectively suppress androgen-dependent tumor expansion of R3327G Dunning prostate adenocarcinoma xenografts in rats (by 66% and 81% with 80 and 120 mg/kg/day p.o., respectively) independent of its androgen biosynthesis inhibition.

storage

Desiccate at RT

LIAROZOLE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LIAROZOLE DIHYDROCHLORIDE Suppliers

Sigma-Aldrich Japan K.K.
Tel
--
Fax
--
Email
sialjp@sial.com
Country
Japan
ProdList
5753
Advantage
58

1883548-96-6, LIAROZOLE DIHYDROCHLORIDERelated Search:


  • LIAROZOLE DIHYDROCHLORIDE
  • R75251 dihydrochloride
  • Liarozole dihydrochloride >=98% (HPLC)
  • 1883548-96-6