LIAROZOLE DIHYDROCHLORIDE

Product Name: LIAROZOLE DIHYDROCHLORIDE
CAS No.: 1883548-96-6
Chemical Name: LIAROZOLE DIHYDROCHLORIDE
Synonyms: R75251 dihydrochloride;LIAROZOLE DIHYDROCHLORIDE;Liarozole dihydrochloride >=98% (HPLC)
CBNumber: CB04740469
Molecular Formula: C17H14Cl2N4
Formula Weight: 345.23
MOL File: 1883548-96-6.mol

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LIAROZOLE DIHYDROCHLORIDE Property

storage temp.: room temp
solubility: Water: ≥ 50 mg/mL (131.00 mM); DMSO: 50 mg/mL (131.00 mM)
form: powder
color: white to beige
Water Solubility: H2O: 2mg/mL, clear

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2705
Product name: Liarozole dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-0033188
Product name: Liarozole dihydrochloride
Purity: ≥99.0%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

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LIAROZOLE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) th at targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyase (CYP17A1), 11-hydroxylase (CYP11B1), and RA 4-hydroxylase (CYP26). Liarozole is more effective than ketoconazole in vivo (plasma RA enhancement = 2.5 ng/mL vs. 1.3 ng/mL 2 hr after respective oral dosage of 40 mg/kg in rats) and, in contrast to ketoconazole, Liarozole does not significantly affect circulating adrenal androgen levels. Liarozole is shown to effectively suppress androgen-dependent tumor expansion of R3327G Dunning prostate adenocarcinoma xenografts in rats (by 66% and 81% with 80 and 120 mg/kg/day p.o., respectively) independent of its androgen biosynthesis inhibition.

storage

Desiccate at RT

LIAROZOLE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LIAROZOLE DIHYDROCHLORIDE Suppliers

China 14 Japan 1 United States 4 USA 1 Global 20

Sigma-Aldrich

Tel: 021-61415566 800-8193336
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Tianjin Kailiqi Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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Country: United States
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Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
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Energy Chemical

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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RD International Technology Co., Limited

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1883548-96-6, LIAROZOLE DIHYDROCHLORIDERelated Search:

LIAROZOLE DIHYDROCHLORIDE

R75251 dihydrochloride

Liarozole dihydrochloride >=98% (HPLC)

1883548-96-6