2-Furanboronic acid
- Product Name
- 2-Furanboronic acid
- CAS No.
- 13331-23-2
- Chemical Name
- 2-Furanboronic acid
- Synonyms
- furan-2-ylboronic acid;2-FURYLBORONIC ACID;FURAN-2-BORONIC ACID;AKOS 90301;Furan-2-acid;2-furan acid;AKOS BRN-0264;2-Boronofuran;2-Furanboronicaci;2-FURANBORONIC ACID
- CBNumber
- CB0474272
- Molecular Formula
- C4H5BO3
- Formula Weight
- 111.89
- MOL File
- 13331-23-2.mol
2-Furanboronic acid Property
- Melting point:
- 112 °C (dec.) (lit.)
- Boiling point:
- 247.7±32.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly)
- pka
- 8.29±0.53(Predicted)
- form
- Crystalline Powder
- color
- Light beige
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Air Sensitive
- BRN
- 112370
- InChI
- InChI=1S/C4H5BO3/c6-5(7)4-2-1-3-8-4/h1-3,6-7H
- InChIKey
- PZJSZBJLOWMDRG-UHFFFAOYSA-N
- SMILES
- O1C=CC=C1B(O)O
- CAS DataBase Reference
- 13331-23-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, AIR SENSITIVE, KEEP COLD
- HS Code
- 29321900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 464910
- Product name
- 2-Furanylboronic acid
- Purity
- ≥95.0%
- Packaging
- 1g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- 464910
- Product name
- 2-Furanylboronic acid
- Purity
- ≥95.0%
- Packaging
- 10g
- Price
- $321.2
- Updated
- 2024/03/01
- Product number
- F0394
- Product name
- 2-Furylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- F0394
- Product name
- 2-Furylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- F864095
- Product name
- Furan-2-boronicacid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
2-Furanboronic acid Chemical Properties,Usage,Production
Chemical Properties
light beige crystalline powder
Uses
It is used in Suzuki reaction for generalized route for the synthesis of β-furyl-α,β-unsaturated aldehydes.
Synthesis
1104637-62-8
13331-23-2
The general procedure for the synthesis of 2-furanboronic acid from 2-(furan-2-yl)-6-methyl-1,3,6,2-dioxaborolane-4,8-dione was as follows: a solution of MIDA borate (5 mmol) in THF (50 mL) was added to a 100 mL flask fitted with a stir bar under an ambient atmosphere followed by the addition of an aqueous 1.0 M NaOH solution (15 mL ). The reaction mixture was stirred vigorously for 20 minutes. Upon completion, the mixture was transferred to a partition funnel and diluted with ether (50 mL) and 0.5 M pH 7 sodium phosphate buffer (50 mL). The phases were separated after sufficient shaking. The aqueous phase was extracted with a solvent mixture of THF/ether (1:1, 2 x 25 mL). The organic phases were combined, dried with anhydrous MgSO4, filtered and concentrated in vacuum. The residual solvent was co-evaporated with acetonitrile and the resulting solid was dried under vacuum at about 1 Torr for 30 min. The resulting boric acid was analyzed by 1H-NMR to be >95% pure and was immediately used in the subsequent cross coupling reaction. Specific examples are as follows: 2-furanboronic acid (0.531 g, 95% yield) was obtained as an off-white solid using MIDA borate (1.127 g, 5.002 mmol) following the general procedure described above.TLC (unfolding reagent: ethyl acetate) Rf = 0.46, stained with potassium permanganate to develop color.1H-NMR (500 MHz, DMSO-d6:D2O 1H-NMR (500 MHz, DMSO-d6:D2O 95:5, with TMS) δ 7.81 (dd, J = 1.5, 5.5 Hz, 1H), 7.07 (dd, J = 3.0, 0.5 Hz, 1H), 6.48 (dd, J = 3.5, 2.0 Hz, 1H). 13C-NMR (125 MHz, DMSO-d6:D2O 95:5, with TMS) δ 146.4, 121.5, 110.3. 121.5, 110.3. HRMS (EI+) calculated value C4H3O3B [M]+: 112.0332, measured value: 112.0332.
References
[1] Journal of the American Chemical Society, 2009, vol. 131, p. 6961 - 6963
[2] Patent: WO2010/36921, 2010, A2. Location in patent: Page/Page column 41
2-Furanboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Furanboronic acid manufacturers
- Product
- 2-Furanboronic acid 13331-23-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-02
- Product
- Furan-2-boronic acid 13331-23-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.7%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- 2-Furanboronic acid 13331-23-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11