ChemicalBook > CAS DataBase List > 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Product Name
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
CAS No.
15421-84-8
Chemical Name
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
Synonyms
ar12008;Trapymin;TRAPIDIL;Avantrin;rocornal;Trapymine;Trapidil CRS;Trapidil (AR12008);Trapidil >=98% (HPLC);5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin
CBNumber
CB0487317
Molecular Formula
C10H15N5
Formula Weight
205.26
MOL File
15421-84-8.mol
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7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Property

Melting point:
98-99.4° (Pfeifer); 102-104° from heptane (Tenor)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: ≥15mg/mL
pka
pKs = 2.79(at 25℃)
form 
powder
color 
white to tan
CAS DataBase Reference
15421-84-8
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
Toxicity
LD50 in mice, rats (mg/kg): 115, 76 i.v.; 380, 235 orally; 155, 100 i.p.; 132, 100 s.c. (Fuller)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0071
Product name
Trapidil
Purity
≥98% (HPLC)
Packaging
50mg
Price
$474
Updated
2022/05/15
Sigma-Aldrich
Product number
T1820000
Product name
Trapidil
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
t1820000
Price
$223
Updated
2024/03/01
Biosynth Carbosynth
Product number
FD153326
Product name
N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD153326
Product name
N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
Packaging
1g
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-4529
Product name
Trapidil
Purity
>98.0%
Packaging
50mg
Price
$288
Updated
2021/12/16
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7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder

Originator

Rocornal,Mochida,Japan,1978

Uses

Vasodilator;PDGF antagonist

Definition

ChEBI: Trapidil is a member of triazolopyrimidines.

Manufacturing Process

8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.

Therapeutic Function

Coronary vasodilator

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Suppliers

Wuhan Diao Pharmaceutical Co., Ltd.
Tel
027-85503088
Email
1879237340@qq.com
Country
China
ProdList
3
Advantage
58
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
1000
Advantage
62
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4531
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Shanghai Synthfine Chemical Co.,Ltd
Tel
15921303235
Fax
QQ489466966
Email
sales@synthfine.com
Country
China
ProdList
989
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17944
Advantage
56
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View Lastest Price from 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE manufacturers

airuikechemical co., ltd.
Product
Trapidil 15421-84-8
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-03-13
Dideu Industries Group Limited
Product
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE 15421-84-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-06
Shaanxi Dideu Medichem Co. Ltd
Product
Trapidil 15421-84-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

15421-84-8, 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINERelated Search:


  • TRAPIDIL
  • 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
  • 7-Diethylamino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine
  • N,N-Diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
  • Trapymin
  • N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
  • 7-(Diethylamino)-5-methyl-S-triazolo[1,5-a]pyrimidine ,98%
  • Avantrin
  • Trapymine
  • [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-
  • 5-a)pyrimidin-7-amine,n,n-diethyl-5-methyl-s-triazolo(
  • 5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin
  • 5-methyl-7-diethylamino-s-triazolo-(1,5-a)-pyrimidine
  • ar12008
  • n,n-diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-7-amine
  • rocornal
  • Trapidil CRS
  • Trapidil >=98% (HPLC)
  • 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE USP/EP/BP
  • Trapidil (AR12008)
  • N,N-Diethyl-4-methyl-1,5,7,9-Tetrazabicyclo[4.3.0]Nona-2,4,6,8-Tetraen-2-Amine
  • 15421-84-8