7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
- Product Name
- 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
- CAS No.
- 15421-84-8
- Chemical Name
- 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
- Synonyms
- ar12008;Trapymin;TRAPIDIL;Avantrin;rocornal;Trapymine;Trapidil CRS;Trapidil (AR12008);Trapidil >=98% (HPLC);5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin
- CBNumber
- CB0487317
- Molecular Formula
- C10H15N5
- Formula Weight
- 205.26
- MOL File
- 15421-84-8.mol
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Property
- Melting point:
- 98-99.4° (Pfeifer); 102-104° from heptane (Tenor)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- H2O: ≥15mg/mL
- pka
- pKs = 2.79(at 25℃)
- form
- powder
- color
- white to tan
- CAS DataBase Reference
- 15421-84-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0071
- Product name
- Trapidil
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $474
- Updated
- 2022/05/15
- Product number
- T1820000
- Product name
- Trapidil
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- t1820000
- Price
- $223
- Updated
- 2024/03/01
- Product number
- FD153326
- Product name
- N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD153326
- Product name
- N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-4529
- Product name
- Trapidil
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $288
- Updated
- 2021/12/16
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
White or almost white, crystalline powder
Originator
Rocornal,Mochida,Japan,1978
Uses
Vasodilator;PDGF antagonist
Definition
ChEBI: Trapidil is a member of triazolopyrimidines.
Manufacturing Process
8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.
Therapeutic Function
Coronary vasodilator
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE manufacturers
- Product
- Trapidil 15421-84-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-03
- Product
- Trapidil 15421-84-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11