FASCAPLYSIN CHLORIDE
- Product Name
- FASCAPLYSIN CHLORIDE
- CAS No.
- 114719-57-2
- Chemical Name
- FASCAPLYSIN CHLORIDE
- Synonyms
- fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI)
- CBNumber
- CB0503495
- Molecular Formula
- C18H11ClN2O
- Formula Weight
- 306.74574
- MOL File
- 114719-57-2.mol
FASCAPLYSIN CHLORIDE Property
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
- form
- solid
- color
- Dark red-brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-61-45-20/21/22
- Safety Statements
- 26-53-45-36/37/39
N-Bromosuccinimide Price
- Product number
- 341251
- Product name
- Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem
- Packaging
- 1mg
- Price
- $140
- Updated
- 2023/01/07
- Product number
- 21715
- Product name
- Fascaplysin (chloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 21715
- Product name
- Fascaplysin (chloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- F150013
- Product name
- FascaplysinChloride
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- orb573160
- Product name
- Fascaplysin (chloride)|CDK4 inhibitor
- Packaging
- 1g
- Price
- $3580.2
- Updated
- 2021/12/16
FASCAPLYSIN CHLORIDE Chemical Properties,Usage,Production
Description
Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
Uses
Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.
References
1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877 2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439 3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377