SALVINORIN A

Product Name: SALVINORIN A
CAS No.: 83729-01-5
Chemical Name: SALVINORIN A
Synonyms: Salvinorin;Divinorin A;SALVINORIN A;SALVINORIN A(P);Salvinorin A solution;Salvinorin A (Divinorin A);Salvinorin A, 10 mM in DMSO;Salvinorin A (Divinorin A), kappa agonist;(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester;(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
CBNumber: CB0506991
Molecular Formula: C23H28O8
Formula Weight: 432.46
MOL File: 83729-01-5.mol

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SALVINORIN A Property

Melting point:: 238-240° (Ortega); mp 242-244° (Valdes, 1984)
alpha: D22 -45.3° (c = 8.530 in CHCl3); D25 -41° (c = 1 in CHCl3)
Boiling point:: 563.8±50.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
Flash point:: 2℃
storage temp.: −20°C
solubility: DMSO: ≥10mg/mL
form: powder
color: white

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Safety

Hazard Codes: F,Xn
Risk Statements: 11-20/21/22-36
Safety Statements: 22-24/25-36/37-16
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
RTECS: QL6127142
Hazardous Substances Data: 83729-01-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S8071
Product name: Salvinorin A
Purity: ≥98% (HPLC), powder
Packaging: 1mg
Price: $205.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.08159
Product name: Salvinorin A - CAS 83729-01-5 - Calbiochem
Packaging: 1MG
Price: $187
Updated: 2025/07/31

Sigma-Aldrich

Product number: S-012
Product name: Salvinorin A solution
Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $164
Updated: 2022/05/15

Cayman Chemical

Product number: 11487
Product name: Salvinorin A
Purity: ≥95%
Packaging: 1mg
Price: $132
Updated: 2024/03/01

Cayman Chemical

Product number: 11487
Product name: Salvinorin A
Purity: ≥95%
Packaging: 5mg
Price: $494
Updated: 2024/03/01

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SALVINORIN A Chemical Properties,Usage,Production

Description

Salvinorin A (Item No. 11487) is an analytical reference material categorized as a diterpene. It is a hallucinogen derived from S. divinorum that has been used in the traditional spiritual practices of the Mazatec Indians and as a recreational drug. This product is intended for research and forensic applications.

Uses

Salvinorin A is a potent and selective kappa-opioid receptor agonist. Salvinorin A has been reported to be brain-penetrant and displays psychoactive properties; hallucinogen.

Uses

Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ-opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM). This product is intended for forensic and research applications.In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Uses

In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Definition

ChEBI: A natural product found in Salvia divinorum.

Biological Activity

Potent naturally occuring non-nitrogenous κ -opioid selective agonist that displays high affinity at both native (K i = 4.3 nM) and cloned (K i = 16 nM) κ -opioid receptors. Also exhibits allosteric modulation of μ -opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties.

Biochem/physiol Actions

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

References

[1] BRYAN L ROTH. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 1: 11934-11939. DOI: 10.1073/pnas.182234399
[2] WAYNE W. HARDING. Salvinicins A (I) and B (II), New Neoclerodane Diterpenes from Salvia divinorum.[J]. ChemInform, 2005, 36 47. DOI: 10.1002/chin.200547181
[3] KENJI TSUJIKAWA . Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan[J]. Forensic science international, 2008, 180 2: Pages 105-109. DOI: 10.1016/j.forsciint.2008.07.008
[4] THOMAS A. MUNRO . Standard protecting groups create potent and selective κ opioids: Salvinorin B alkoxymethyl ethers[J]. Bioorganic & Medicinal Chemistry, 2008, 16 3: Pages 1279-1286. DOI: 10.1016/j.bmc.2007.10.067
[5] NICHOLAS J MALCOLM. Mu-opioid receptor selective superagonists produce prolonged respiratory depression.[J]. iScience, 2023, 26 7: 107121. DOI: 10.1016/j.isci.2023.107121

SALVINORIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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SALVINORIN A Suppliers

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83729-01-5, SALVINORIN ARelated Search:

Paeonol Protocatechualdehyde lithospermic acid B 2-ETHOXYCYCLOHEXANONE (S)-2-METHOXYCYCLOHEXANONE (2S,4aR,6aR,7R,9S,10aS,10bR)-Methyl 9-(benzoyloxy)-2-(furan-3-yl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-1H-benzo[f]isochromene-7-carboxylate ETHYL 7-OXODECANOATE ETHYL 7-OXONONANOATE SALVINORIN A ETHYL 7-OXOUNDECANOATE tetrahydro-3-pentyl-2H-pyran-2-one 5-CYCLOHEXYL-5-OXOVALERIC ACID ethyl 5-oxodecanoate 5-OXOAZELAIC ACID

Salvinorin A solution

[2S-(2α,4aα,6aβ,7β,9β,10aα,10bβ)]-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-diMethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic Acid Methyl Ester

Salvinorin

2H-Naphtho[2,1-c]pyran-7-carboxylicacid, 9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-,methyl ester, (2S,4aR,6aR,7R,9S,10aS,10bR)-

SALVINORIN A(P)

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Divinorin A

SALVINORIN A

Salvinorin A (Divinorin A), kappa agonist

Salvinorin A, 10 mM in DMSO

Salvinorin A (Divinorin A)

83729-01-5

Neurochcemicals

Agonist

Heterocycles

Opioids

Intermediates & Fine Chemicals

Pharmaceuticals

Opioid receptor and opioid-like receptor