ethyl 2-(2-aminothiazol-5-ylthio)acetate
- Product Name
- ethyl 2-(2-aminothiazol-5-ylthio)acetate
- CAS No.
- 859522-19-3
- Chemical Name
- ethyl 2-(2-aminothiazol-5-ylthio)acetate
- Synonyms
- EOS-60383;Ethyl 2-((2-aminothiazol-5-yl);ethyl 2-(2-aminothiazol-5-ylthio)acetate;ethyl [(2-aMino-1,3-thiazol-5-yl)sulfanyl]acetate;2-[(2-amino-5-thiazolyl)thio]Acetic acid ethyl ester;ethyl2-((2-aminothiazol-5-yl)thio)acetatehydrobromide;Acetic acid, 2-[(2-amino-5-thiazolyl)thio]-, ethyl ester
- CBNumber
- CB0547253
- Molecular Formula
- C7H10N2O2S2
- Formula Weight
- 218.3
- MOL File
- 859522-19-3.mol
ethyl 2-(2-aminothiazol-5-ylthio)acetate Property
- Boiling point:
- 368.9±22.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.87±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- W8838
- Product name
- Ethyl2-(2-aminothiazol-5-ylthio)acetate
- Packaging
- 1g
- Price
- $456
- Updated
- 2021/12/16
- Product number
- CHM0384412
- Product name
- ETHYL-2-(2-AMINOTHIAZOL-5-YL-THIO)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.02
- Updated
- 2021/12/16
- Product number
- CM132250
- Product name
- ethyl2-((2-aminothiazol-5-yl)thio)acetate
- Purity
- 95%
- Packaging
- 5g
- Price
- $847
- Updated
- 2021/12/16
- Product number
- 859522193
- Product name
- Ethyl2-((2-aminothiazol-5-yl)thio)acetate
- Packaging
- 5g
- Price
- $865
- Updated
- 2021/12/16
- Product number
- CD11043022
- Product name
- Ethyl2-((2-aminothiazol-5-yl)thio)acetate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $896
- Updated
- 2021/12/16
ethyl 2-(2-aminothiazol-5-ylthio)acetate Chemical Properties,Usage,Production
Synthesis
61296-22-8
623-51-8
859522-19-3
General procedure for the synthesis of ethyl 2-(2-aminothiazole-5-thio)acetate from 2-amino-5-bromothiazole hydrobromide and ethyl thioglycolate: In a dry reaction flask, 2-amino-5-bromothiazole hydrobromide (7.26 g, 27.9 mmol), ethyl thioglycolate (10 g, 83.8 mmol) and potassium carbonate (7.7 g, 55.9 mmol) were dissolved in N,N-dimethylformamide (DMF, 25 mL). The reaction mixture was stirred at 50 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble material. Water (150 mL) and ethyl acetate (400 mL) were added to the filtrate, and the organic phase was separated by thorough stirring. The organic phase was washed with saturated brine (3 x 50 mL) and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give ethyl 2-(2-aminothiazol-5-ylthio)acetate. Yield: 3.3 g (54%). 1H-NMR (DMSO-d6) δ: 7.6 (s, 2H, NH2), 7.00 (s, 1H, thiazole-H), 4.08 (q, 2H, OCH2CH3), 3.45 (s, 2H, SCH2), 1.17 (t, 3H, OCH2CH3).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 9, p. 2063 - 2068
[2] Patent: WO2006/58923, 2006, A1. Location in patent: Page/Page column 51
ethyl 2-(2-aminothiazol-5-ylthio)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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