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DL-Dithiothreitol

Product Name
DL-Dithiothreitol
CAS No.
27565-41-9
Chemical Name
DL-Dithiothreitol
Synonyms
DTT;1,4-DITHIOTHREITOL;1,4-DITHIO-DL-THREITOL;Cleland's reagent;DTT-MBG;DITHIOTHRIETOL;(2R,3R)-1,4-dimercaptobutane-2,3-diol;DITT;DL-DTT;CGMP DTT
CBNumber
CB3342918
Molecular Formula
C4H10O2S2
Formula Weight
154.25
MOL File
27565-41-9.mol
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DL-Dithiothreitol Property

Melting point:
41-44 °C(lit.)
Boiling point:
125-130 °C (2 mmHg)
Density 
1.04 g/mL at 20 °C
refractive index 
1.5200 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
Liquid
color 
White
Water Solubility 
Soluble
Merck 
3376
InChI
InChI=1/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/s3
InChIKey
VHJLVAABSRFDPM-APQYWOSTNA-N
SMILES
[C@@H](O)(CS)[C@H](O)CS |&1:0,4,r|
CAS DataBase Reference
27565-41-9(CAS DataBase Reference)
EPA Substance Registry System
2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-(27565-41-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
25-36/37/38-22
Safety Statements 
26-45-36
WGK Germany 
3
RTECS 
EK1610000
F 
3-10-16-23
HS Code 
29309090
Toxicity
mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
D1933
Product name
(+/-)-1,4-Dithiothreitol-d6
Packaging
100mg
Price
$690
Updated
2021/12/16
Soltec Ventures
Product number
M112
Product name
(D,L)-1,4-Dithiothreitol,99.5+%,MolecularBiologyGrade
Purity
MolecularBiologyGrade
Packaging
5gm
Price
$31
Updated
2021/12/16
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DL-Dithiothreitol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins.

Uses

DTT is a cell permeable protective agent for Thiol groups.

Preparation

The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis.

Definition

ChEBI: D-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a L-1,4-dithiothreitol.

Purification Methods

Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.]

DL-Dithiothreitol Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-(2-aminothiazol-5-ylthio)acetate
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DL-Dithiothreitol Suppliers

Canada 1 China 204 Czech 1 Europe 2 France 1 Germany 8 India 2 Japan 3 South Korea 1 Sweden 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 8 United States 45 Global 281
Jiangsu Boquan Biotechnology Co., Ltd.
Tel
19025100081
Email
5954981@qq.com
Country
China
ProdList
2032
Advantage
58
Hefei Bomei Biotechnology Co., Ltd.
Tel
13739298932
Email
531626407@qq.com
Country
China
ProdList
3010
Advantage
58
Hunan Zhangjiajie Hengkang Biological Pharmaceutical Co., LTD
Tel
0731-85561023 18973109536
Email
hengkangapi@hengkangapi.com
Country
China
ProdList
401
Advantage
58
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
ProdList
5093
Advantage
55
Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5095
Advantage
55
Hunan Hui Bai Yi New Materials Co., Ltd
Tel
0745-2866551 19976851779
Email
3002713163@qq.com
Country
China
ProdList
7333
Advantage
58
Hubei deante Chemical Technology Co., Ltd
Tel
18707110115
Email
1686725535@qq.com
Country
China
ProdList
629
Advantage
58
Huai Hua Binfengchem Co., Ltd
Tel
0745-2866851 17774575249
Email
sales@bingfengchem.com
Country
China
ProdList
445
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
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View Lastest Price from DL-Dithiothreitol manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
D-1,4-dithiothreitol 27565-41-9
Price
US $2.20-8.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
DL-Dithiothreitol 27565-41-9
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Anhui Ruihan Technology Co., Ltd
Product
DL-Dithiothreitol 27565-41-9
Price
US $80.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11

27565-41-9, DL-DithiothreitolRelated Search:

3,3'-Thiodipropionic acid Phenothiazine 2,2'-Dithiosalicylic acid 1,4-Butanediol 2,3-Butanediol threitol 2,2'-Thiodiethanol DL-Dithiothreitol L-DITHIOTHREITOL TRANS-4,5-DIHYDROXY-1,2-DITHIANE 1,4-BUTANEDITHIOL 3-Mercapto-1,2-propanediol Butanethiol L-THREITOL 1,4-DITHIOTHREITOL-1,1,2,3,4,4-D6 1-MERCAPTO-2-PROPANOL dl-dithiothreitol-d10 DL-THREITOL

  • DTT-MBG
  • DTT (RACEMIC)
  • DL-THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE
  • DL-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL
  • DL-DTT
  • DITHIOTHREITOL, 1,4-
  • DITT
  • DITHIOTHRIETOL
  • DL-2,3-DIHYDROXY-1,4-BUTANEDITHIOL
  • DL-1,4-DIMERCAPTO-2,3-BUTANEDIOL
  • CGMP DTT
  • CLELAND REAGENT RACEMIC
  • CLELAND'S REAGENT, IMMOBILIZED
  • CLELAND'S REDUCTACRYL(TM) REAGENT
  • 2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-
  • (2S,3S:2R,3R)-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL
  • 1,4-DITHIO-DL-THREITOL
  • 1,4-DITHIOTHREITHOL
  • 1,4-DITHIOTHREITOL
  • RAC-CLELAND'S REAGENT
  • (R,R)-DITHIOTHREITOL
  • (R,R)-1,4-DIMERCAPTO-2,3-BUTANEDIOL
  • THREO-2,3-DIHYDROXY-1,4-DITHIOBUTANE
  • THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE
  • SPUTOLYSIN(R) REAGENT
  • 1,4-dimercapto-,(r*,r*)-(+-)-3-butanediol
  • 1,4-dimercapto-,(theta,theta)-(+/-)-3-butanediol
  • 4-dimercapto-3-butanediodl-threo-1
  • 4-dithio-dl-threito
  • rac-dithiothreitol
  • 1 4-DITHIO-DL-THREITOL(+4℃)
  • Di-dithiothreitol
  • DTT(1,4-Dithiothreitol
  • 1,4-Dithio-DL-threitol≥ 99% (Titration)
  • (2R,3R)-1,4-dimercaptobutane-2,3-diol
  • 1,4-dithio-dl-threitol sol.
  • Clelands REDUCTACRYL
  • dithiothreitol (dtt) sequencing grade
  • dithiothreitol molecular biology*reagent
  • DithiothreitollelandsReagenz
  • Dithithreitol
  • DL-Dithothreitol
  • (R*,R*)-(±)-1,4-dimercaptobutane-2,3-diol
  • 2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-()-OR,DITHIOTHREITOL
  • Dtt(Dl-Dithiothreitol)
  • (±)-1,4-Dithiothreitol-D6
  • DL-DITHIOTHREITOL,ELECTROPHORESISGRADE
  • (+/-)-1,4-Dithio-D-threitol
  • Cleland's reagent
  • DTT
  • D-Dithiothreitol, (2S,3S)-threo-1,4-Dimercapto-2,3-butandiol
  • DL-DITHIOTHREITOL extrapure
  • 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-
  • DL-1,4-Dimercapto-2,3-dihydroxybutane
  • threo-2,3-Dihydroxy-1,4-butanedithiol
  • DL-Dithiothreitol [for Electrophoresis]
  • DL-1,4-Dithiothreitol ,98%
  • DITHIOTHREITOL RESEARCH GRADE