DL-Dithiothreitol
- Product Name
- DL-Dithiothreitol
- CAS No.
- 27565-41-9
- Chemical Name
- DL-Dithiothreitol
- Synonyms
- DTT;1,4-DITHIOTHREITOL;1,4-DITHIO-DL-THREITOL;Cleland's reagent;DTT-MBG;DITHIOTHRIETOL;(2R,3R)-1,4-dimercaptobutane-2,3-diol;DITT;DL-DTT;CGMP DTT
- CBNumber
- CB3342918
- Molecular Formula
- C4H10O2S2
- Formula Weight
- 154.25
- MOL File
- 27565-41-9.mol
DL-Dithiothreitol Property
- Melting point:
- 41-44 °C(lit.)
- Boiling point:
- 125-130 °C (2 mmHg)
- Density
- 1.04 g/mL at 20 °C
- refractive index
- 1.5200 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL, clear, colorless
- form
- Liquid
- color
- White
- Water Solubility
- Soluble
- Merck
- 3376
- CAS DataBase Reference
- 27565-41-9(CAS DataBase Reference)
- EPA Substance Registry System
- 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-(27565-41-9)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 25-36/37/38-22
- Safety Statements
- 26-45-36
- WGK Germany
- 3
- RTECS
- EK1610000
- F
- 3-10-16-23
- HS Code
- 29309090
- Toxicity
- mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D1933
- Product name
- (+/-)-1,4-Dithiothreitol-d6
- Packaging
- 100mg
- Price
- $690
- Updated
- 2021/12/16
- Product number
- M112
- Product name
- (D,L)-1,4-Dithiothreitol,99.5+%,MolecularBiologyGrade
- Purity
- MolecularBiologyGrade
- Packaging
- 5gm
- Price
- $31
- Updated
- 2021/12/16
DL-Dithiothreitol Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins.
Uses
DTT is a cell permeable protective agent for Thiol groups.
Preparation
The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis.
Definition
ChEBI: D-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a L-1,4-dithiothreitol.
Purification Methods
Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.]
DL-Dithiothreitol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DL-Dithiothreitol manufacturers
- Product
- DL-Dithiothreitol 27565-41-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-26
- Product
- DL-Dithiothreitol 27565-41-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-11-20
- Product
- DL-Dithiothreitol 27565-41-9
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-11