DL-Dithiothreitol

ChemicalBook > CAS DataBase List > DL-Dithiothreitol

Product Name: DL-Dithiothreitol
CAS No.: 27565-41-9
Chemical Name: DL-Dithiothreitol
Synonyms: DTT;1,4-DITHIOTHREITOL;1,4-DITHIO-DL-THREITOL;Cleland's reagent;DTT-MBG;DITHIOTHRIETOL;(2R,3R)-1,4-dimercaptobutane-2,3-diol;DITT;DL-DTT;CGMP DTT
CBNumber: CB3342918
Molecular Formula: C4H10O2S2
Formula Weight: 154.25
MOL File: 27565-41-9.mol

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DL-Dithiothreitol Property

Melting point:: 41-44 °C(lit.)
Boiling point:: 125-130 °C (2 mmHg)
Density: 1.04 g/mL at 20 °C
refractive index: 1.5200 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, clear, colorless
form: Liquid
color: White
Water Solubility: Soluble
Merck: 3376
CAS DataBase Reference: 27565-41-9(CAS DataBase Reference)
EPA Substance Registry System: 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-(27565-41-9)

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Safety

Hazard Codes: Xn
Risk Statements: 25-36/37/38-22
Safety Statements: 26-45-36
WGK Germany: 3
RTECS: EK1610000
F: 3-10-16-23
HS Code: 29309090
Toxicity: mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Medical Isotopes, Inc.

Product number: D1933
Product name: (+/-)-1,4-Dithiothreitol-d6
Packaging: 100mg
Price: $690
Updated: 2021/12/16

Soltec Ventures

Product number: M112
Product name: (D,L)-1,4-Dithiothreitol,99.5+%,MolecularBiologyGrade
Purity: MolecularBiologyGrade
Packaging: 5gm
Price: $31
Updated: 2021/12/16

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DL-Dithiothreitol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins.

Uses

DTT is a cell permeable protective agent for Thiol groups.

Preparation

The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis.

Definition

ChEBI: D-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a L-1,4-dithiothreitol.

Purification Methods

Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.]

DL-Dithiothreitol Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-(2-aminothiazol-5-ylthio)acetate

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View Lastest Price from DL-Dithiothreitol manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: DL-Dithiothreitol 27565-41-9
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-26

Hebei Weibang Biotechnology Co., Ltd

Product: DL-Dithiothreitol 27565-41-9
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Mujin Biotechnology Co.,Ltd

Product: DL-Dithiothreitol 27565-41-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-11-20

27565-41-9, DL-DithiothreitolRelated Search:

3,3'-Thiodipropionic acid Phenothiazine 2,2'-Dithiosalicylic acid 1,4-Butanediol 2,3-Butanediol threitol 2,2'-Thiodiethanol DL-Dithiothreitol L-DITHIOTHREITOL TRANS-4,5-DIHYDROXY-1,2-DITHIANE 1,4-BUTANEDITHIOL 3-Mercapto-1,2-propanediol Butanethiol L-THREITOL 1,4-DITHIOTHREITOL-1,1,2,3,4,4-D6 1-MERCAPTO-2-PROPANOL dl-dithiothreitol-d10 DL-THREITOL

DTT-MBG

DTT (RACEMIC)

DL-THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE

DL-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL

DL-DTT

DITHIOTHREITOL, 1,4-

DITT

DITHIOTHRIETOL

DL-2,3-DIHYDROXY-1,4-BUTANEDITHIOL

DL-1,4-DIMERCAPTO-2,3-BUTANEDIOL

CGMP DTT

CLELAND REAGENT RACEMIC

CLELAND'S REAGENT, IMMOBILIZED

CLELAND'S REDUCTACRYL(TM) REAGENT

2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-

(2S,3S:2R,3R)-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL

1,4-DITHIO-DL-THREITOL

1,4-DITHIOTHREITHOL

1,4-DITHIOTHREITOL

RAC-CLELAND'S REAGENT

(R,R)-DITHIOTHREITOL

(R,R)-1,4-DIMERCAPTO-2,3-BUTANEDIOL

THREO-2,3-DIHYDROXY-1,4-DITHIOBUTANE

THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE

SPUTOLYSIN(R) REAGENT

1,4-dimercapto-,(r*,r*)-(+-)-3-butanediol

1,4-dimercapto-,(theta,theta)-(+/-)-3-butanediol

4-dimercapto-3-butanediodl-threo-1

4-dithio-dl-threito

rac-dithiothreitol

1 4-DITHIO-DL-THREITOL(+4℃)

Di-dithiothreitol

DTT(1,4-Dithiothreitol

1,4-Dithio-DL-threitol≥ 99% (Titration)

(2R,3R)-1,4-dimercaptobutane-2,3-diol

1,4-dithio-dl-threitol sol.

Clelands REDUCTACRYL

dithiothreitol (dtt) sequencing grade

dithiothreitol molecular biology*reagent

DithiothreitollelandsReagenz

Dithithreitol

DL-Dithothreitol

(R*,R*)-(±)-1,4-dimercaptobutane-2,3-diol

2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-()-OR,DITHIOTHREITOL

Dtt(Dl-Dithiothreitol)

(±)-1,4-Dithiothreitol-D6

DL-DITHIOTHREITOL,ELECTROPHORESISGRADE

(+/-)-1,4-Dithio-D-threitol

Cleland's reagent

DTT

D-Dithiothreitol, (2S,3S)-threo-1,4-Dimercapto-2,3-butandiol

DL-DITHIOTHREITOL extrapure

2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-

DL-1,4-Dimercapto-2,3-dihydroxybutane

threo-2,3-Dihydroxy-1,4-butanedithiol

DL-Dithiothreitol [for Electrophoresis]

DL-1,4-Dithiothreitol ,98%

DITHIOTHREITOL RESEARCH GRADE