VH 101, phenol

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Product Name: VH 101, phenol
CAS No.: 2306193-99-5
Chemical Name: VH 101, phenol
Synonyms: Phenolic VH101;VH 101, phenol;E3 ligase Ligand 19;VH032-cyclopropane-F;(2S,4R)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;Inhibitor,E3 ligase-recruiting Moiety,inhibit,VHL ligand3,Ligands for E3 Ligase,VH032 cyclopropane F,VH032cyclopropaneF,VHL ligand-3,VH-032-cyclopropane-F;(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB05965564
Molecular Formula: C26H33FN4O5S
Formula Weight: 532.63
MOL File: 2306193-99-5.mol

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VH 101, phenol Property

Boiling point:: 841.7±65.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO
pka: 9.12±0.35(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6952
Product name: VH101,phenol
Purity: ≥98%(HPLC)
Packaging: 50
Price: $669
Updated: 2021/12/16

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VH 101, phenol Chemical Properties,Usage,Production

Uses

VH032-cyclopropane-F (VH 101, phenol) is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

storage

Store at +4°C

VH 101, phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2306193-99-5, VH 101, phenolRelated Search:

E3 ligase Ligand-Linker Conjugates 29 VH 032 phenol-linker 1 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide VH032 thiol HaloPROTAC 2

E3 ligase Ligand 19

VH032-cyclopropane-F

VH 101, phenol

(2S,4R)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Phenolic VH101

Inhibitor,E3 ligase-recruiting Moiety,inhibit,VHL ligand3,Ligands for E3 Ligase,VH032 cyclopropane F,VH032cyclopropaneF,VHL ligand-3,VH-032-cyclopropane-F

(2S,4R)-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2306193-99-5

C26H33FN4O5S