VH032 thiol

Product Name: VH032 thiol
CAS No.: 2098836-54-3
Chemical Name: VH032 thiol
Synonyms: VHL ligand 6;VH032 THIOL (VHL LIGAND 6);L-Prolinamide, N-acetyl-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((R)-2-Acetamido-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2R)-2-acetamido-3-methyl-3-sulfanylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB65540347
Molecular Formula: C23H30N4O4S2
Formula Weight: 490.64
MOL File: 2098836-54-3.mol

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VH032 thiol Property

Boiling point:: 805.1±65.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
solubility: DMSO : 50 mg/mL (101.91 mM; Need ultrasonic)
pka: 10.17±0.10(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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VH032 thiol Chemical Properties,Usage,Production

Uses

VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC[1].

IC 50

VHL

storage

Store at -20°C

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

VH032 thiol Preparation Products And Raw materials

Raw materials

Preparation Products

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VH032 thiol Suppliers

China 14 United States 1 Global 15

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai hongqu biomedical technology co. LTD

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Affinity（Wuhan）Ltd.

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TargetMol Chemicals Inc.

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ShenZhen Trendseen Biological Technology Co.,Ltd.

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R&D Systems, Inc

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2098836-54-3, VH032 thiolRelated Search:

E3 ligase Ligand-Linker Conjugates 29 VH 032 phenol-linker 1 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide HaloPROTAC 2 VH 101, phenol

VH032 THIOL (VHL LIGAND 6)

VHL ligand 6

L-Prolinamide, N-acetyl-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(2S,4R)-1-((R)-2-Acetamido-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-[(2R)-2-acetamido-3-methyl-3-sulfanylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2098836-54-3