E3 ligase Ligand-Linker Conjugates 29

Product Name: E3 ligase Ligand-Linker Conjugates 29
CAS No.: 2098836-63-4
Chemical Name: E3 ligase Ligand-Linker Conjugates 29
Synonyms: VH032-thiol-C6-NH2;VHL Ligand-Linker Conjugates 14;E3 ligase Ligand-Linker Conjugates 29;L-Prolinamide, N-acetyl-3-[(6-aminohexyl)thio]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-[(2R)-3-[(6-aminohexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB58054806
Molecular Formula: C29H43N5O4S2
Formula Weight: 589.82
MOL File: 2098836-63-4.mol

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E3 ligase Ligand-Linker Conjugates 29 Property

Boiling point:: 868.6±65.0 °C(Predicted)
Density: 1.232±0.06 g/cm3(Predicted)
pka: 14.05±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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E3 ligase Ligand-Linker Conjugates 29 Chemical Properties,Usage,Production

Uses

VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.

IC 50

VHL

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

E3 ligase Ligand-Linker Conjugates 29 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 29 Suppliers

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2098836-63-4, E3 ligase Ligand-Linker Conjugates 29Related Search:

VH032 thiol VH 032 phenol-linker 1 HaloPROTAC 2 VH 101, phenol (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

E3 ligase Ligand-Linker Conjugates 29

VH032-thiol-C6-NH2

VHL Ligand-Linker Conjugates 14

(2S,4R)-1-[(2R)-3-[(6-aminohexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

L-Prolinamide, N-acetyl-3-[(6-aminohexyl)thio]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

2098836-63-4