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2-AMINO-6-CHLORO-PHENOL

Product Name
2-AMINO-6-CHLORO-PHENOL
CAS No.
38191-33-2
Chemical Name
2-AMINO-6-CHLORO-PHENOL
Synonyms
2-AMino-6-chlorphenol;2-AMINO-6-CHLORO-PHENOL;2-chloro-6-aMinophenole;3-Chloro-2-hydroxyaniline;phenol, 2-amino-6-chloro-
CBNumber
CB0655640
Molecular Formula
C6H6ClNO
Formula Weight
143.57
MOL File
38191-33-2.mol
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2-AMINO-6-CHLORO-PHENOL Property

Melting point:
80-81℃
Boiling point:
247℃
Density 
1.406
Flash point:
103℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
8.28±0.10(Predicted)
color 
Grey
InChI
InChI=1S/C6H6ClNO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H,8H2
InChIKey
QUIIUKFPLUUSGQ-UHFFFAOYSA-N
SMILES
C1(O)=C(Cl)C=CC=C1N
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Safety

Hazard Codes 
Xi
WGK Germany 
WGK 3
HazardClass 
IRRITANT
HS Code 
2922290090
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
Eye Irrit. 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
TMT00393
Product name
2-Amino-6-chlorophenol
Packaging
1 g
Price
$550
Updated
2025/07/31
TRC
Product number
A576675
Product name
2-Amino-6-chlorophenol
Packaging
500mg
Price
$40
Updated
2021/12/16
TRC
Product number
A576675
Product name
2-Amino-6-chlorophenol
Packaging
5g
Price
$300
Updated
2021/12/16
Matrix Scientific
Product number
020009
Product name
2-Amino-6-chlorophenol
Packaging
1g
Price
$23
Updated
2021/12/16
AK Scientific
Product number
J94138
Product name
2-Amino-6-chloro-phenol
Packaging
5g
Price
$105
Updated
2021/12/16
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2-AMINO-6-CHLORO-PHENOL Chemical Properties,Usage,Production

Uses

2-Amino-6-Chlorophenol is used to synthesize HT2C receptor agonists with high selectivity in functional and binding assays.

Synthesis

603-86-1

38191-33-2

General procedure for the synthesis of 2-amino-6-chlorophenol from 2-chloro-6-nitrophenol: 2-chloro-6-nitrophenol (1.05 g, 6.03 mmol) was mixed with tin powder (2.32 g, 19.5 mmol) in glacial acetic acid, and the reaction was stirred for 18 hours at 80 °C. After completion of the reaction, the reaction mixture was diluted with deionized water (120 mL) and filtered to remove insoluble material. The filtrate was extracted with ethyl acetate (1 x 100 mL, followed by 2 x 50 mL). The organic phases were combined, washed with saturated saline (3 × 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by rapid column chromatography on silica gel (eluent ratio 2:1 hexane:ethyl acetate) afforded 2-amino-6-chlorophenol as a brown to white crystalline solid (476 mg, 55% yield).1H-NMR (500 MHz, CDCl3) δ 6.73 (dd, J = 1.7, 8.1 Hz, 1H), 6.69 (t, J = 7.8 Hz, 1H ), 6.62 (dd, J = 1.7, 7.7 Hz, 1H), 5.46 (br s, 1H), 3.84 (br s, 2H); 13C-NMR (125 MHz, CDCl3) δ 139.32, 135.73, 121.28, 119.87, 118.31, 114.42; ESI-MS m/z 144 [M +H]+, calculated value of 144 for the molecular formula C6H7ClNO.

References

[1] Liebigs Annalen der Chemie, 1994, # 3, p. 269 - 276
[2] Journal of the Iranian Chemical Society, 2018, vol. 15, # 2, p. 281 - 291
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 7974 - 7985
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3521 - 3525
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3441 - 3449

2-AMINO-6-CHLORO-PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-6-CHLORO-PHENOL Suppliers

China 87 India 3 United Kingdom 3 United States 6 Global 99
Nanjing Xiezun Chemical Co., Ltd.
Tel
025-85629050 13912997845
Fax
025-85620080
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179109486@qq.com
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China
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25
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60
Shandong RuiYue Biotechnology Co., Ltd.
Tel
0531-88581623 18805314509
Fax
0531-88581623
Email
1456922171@126.com
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China
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67
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50
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
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96815
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PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
Fax
86-025-86918232
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sales@pharmablock.com
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China
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5000
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
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China
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35896
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56
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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42934
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64
Beijing Eternalchem Co,. Ltd.
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010-59484199 18611897322
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sales@eternalchem.com
Country
China
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4383
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60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
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info@syntechem.com
Country
China
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12984
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
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China
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8667
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57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com
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China
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7247
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View Lastest Price from 2-AMINO-6-CHLORO-PHENOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Amino-6-chlorophenol 38191-33-2
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-14
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-AMINO-6-CHLORO-PHENOL 38191-33-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08
Shaanxi Dideu Medichem Co. Ltd
Product
2-AMINO-6-CHLORO-PHENOL 38191-33-2
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-13

38191-33-2, 2-AMINO-6-CHLORO-PHENOLRelated Search:

2-CHLORO-4,6-DINITROPHENOL 6-CHLORO-2-AMINOPHENOL-4-SULFONIC ACID 2-Amino-6-chloro-4-nitrophenol 6-Amino-2,4-dichloro-3-methylphenol hydrochloride 2,4-Dichloro-3-methyl-6-nitrophenol 2-CHLORO-6-NITROPHENOL 4-(2-CHLORO-6-NITROPHENOXY)BENZENE-1-SULFONYL CHLORIDE 2-CHLORO-6-NITROANISOLE 2,4-Dichloro-6-nitrophenol 2-[2,4-Bis(tert-pentyl)phenoxy]-N-(3,5-dichloro-2-hydroxy-p-tolyl)butyramide 2,4-Dichloro-3-ethyl-6-nitrophenol 2-AMINO-4,6-DICHLOROPHENOL N-(3,5-DICHLORO-2-HYDROXY-4-METHYLPHENYL)-2-(2,4-DI-TERT-PENTYLPHENOXY)-ACETAMIDE 3-CHLORO-O-ANISIDINE 97 GALLION 1,2-DICHLORO-3-(2,6-DICHLOROPHENOXY)-4-NITROBENZENE AURORA KA-4065 METHYL 3-(2-CHLORO-6-NITROPHENOXY)-2-THIOPHENECARBOXYLATE

  • phenol, 2-amino-6-chloro-
  • 2-chloro-6-aMinophenole
  • 3-Chloro-2-hydroxyaniline
  • 2-AMino-6-chlorphenol
  • 2-AMINO-6-CHLORO-PHENOL
  • 38191-33-2