Diethylene glycol monomethyl ether Property

Melting point:

−70 °C(lit.)

Boiling point:

194 °C(lit.)

Density 

1.023 g/mL at 25 °C(lit.)

vapor density 

4.14 (vs air)

vapor pressure 

0.2 mm Hg ( 20 °C)

refractive index 

n20/D 1.426

Flash point:

183 °F

storage temp. 

Store below +30°C.

form 

Liquid

pka

14.37±0.10(Predicted)

color 

Clear

Odor

Faint pleasant odor

PH

4-7 (200g/l, H2O, 20℃)

explosive limit

1.38-22.7%

Water Solubility 

Miscible

Sensitive 

Hygroscopic

Merck 

14,6037

BRN 

1697812

Stability:

Stable. Incompatible with strong oxidizing agents. Hygroscopic. Store under nitrogen.

InChIKey

SBASXUCJHJRPEV-UHFFFAOYSA-N

LogP

-0.47 at 20℃

CAS DataBase Reference

111-77-3(CAS DataBase Reference)

NIST Chemistry Reference

Ethanol, 2-(2-methoxyethoxy)-(111-77-3)

EPA Substance Registry System

Diethylene glycol monomethyl ether (111-77-3)

Safety

Hazard Codes 

Xn

Risk Statements 

63

Safety Statements 

36/37

WGK Germany 

1

RTECS 

KL6125000

Autoignition Temperature

221 °C

TSCA 

Yes

HS Code 

29094200

Hazardous Substances Data

111-77-3(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 9.21 g/kg (Smyth)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Diethylene glycol monomethyl ether Chemical Properties,Usage,Production

Chemical Properties

Diethylene glycol monomethyl ether (DEGME) is a type of glycol ether and is a colorless, stable hygroscopic liquid with an agreeable odor. It is completely miscible with water, ketones, alcohol, ethers, aromatic hydrocarbons and halogenated hydrocarbons. More specifically, it is miscible with acetone, benzene, carbon tetrachloride, ethyl ether, methanol and water. Exposure to diEGBE is unlikely to occur via inhalation unless it is heated.

Diethylene glycol monomethyl ether is a solvent for dyes, oils, fats, waxes, many natural and synthetic resins, nitrocellulose and cellulose acetate. It is used as a high-boiling solvent in such formulations as printing inks ond pastes, stamp pad inks, textile dye pastes, lacquers, and synthetic resin coatings. Its presence in lacquers eases brushability and flow-out, and minimizes lifting of undercoats.
DEGME is an ethylene-series or E-series glycol ether and is sold by Dow under the tradename Methyl CARBITOL™ solvent. DEGME has a high dilution ratio and a low evaporation rate.It is stable under recommended storage conditions and readily biodegradable.

Occurrence

Has apparently not been reported to occur in nature.

Uses

Diethylene glycol monomethyl ether is an industrial solvent and is also commonly used as a Fuel System Icing Inhibitor (FSII) in jet fuels.

Uses

Diethylene glycol monomethyl ether(DGME) is used as a thermally stable solvent for many substances, such as nitrocellulose, lacquers, varnishes, and dyes.

Uses

Diethylene glycol monomethyl ether is used in textile dye pastes, in lacquer industrial for thinners and quick drying varnishes; solvent for wood stains, hydraulic brake fluid diluent, and as a coupling agent for miscible organic aqueous systems.
Diethylene glycol monoethyl ether is used as a solvent in lacquer, varnishes, and enamels. It is also used in cosmetic products and dermatological preparations and as a solvent in some medicine products. It enhances the percutaneous absorption through the skin and mucosal barriers. It is used in some drugs to enhance absorption.
Diethylene glycol monobutyl ether is used as a solvent in paints, dyes, inks detergents, and cleaners.
Used in the same way as 2-ethoxyethanol where a solvent with a higher boiling point is required.

Preparation

A by-product in the manufacture of ethylene glycol monomethyl ether (Arctander, 1969).

Definition

ChEBI: A hydroxypolyether that is the monomethyl ether derivative of diethylene glycol.

General Description

Colorless liquid with a sweet odor. Floats and mixes with water.

Air & Water Reactions

Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. Water soluble.

Reactivity Profile

2-(2-Methoxyethoxy)ethanol is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

DGME is a mild to moderate toxicant via ingestion or absorption through the skin. High doses produced lowering of hemoglobin levels and increased relative kidney weight. Renaldamagemay occurnear the lethal dose. Eye contact of the liquid can result in mild to moderate irritation
LD50 value, oral (guinea pigs): 4160 mg/kg
Preliminary developmental toxicity test in pregnant mice dosed with DGME indicated teratogenicity of this compound (Hardin et al. 1987; Cheever et al. 1988). Earlier, Doe (1984) reported no teratogenic property of DGME when administered subcutaneously in rats up to 100 mL/kg. In comparison, EGME produced effects at 40 mL/kg..

Fire Hazard

2-(2-Methoxyethoxy)ethanol is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by skin contact and intraperitoneal routes. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. An eye irritant. Combustible when exposed to heat or flame; can react with oxidzing materials. Reacts violently with Ca(OCl)2, chlorosulfonic acid, and oleum. To fight fire, use dry chemical, alcohol foam, water spray or mist, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.

Purification Methods

Purify as for diethylene glycol mono-n-butyl ether. [Beilstein 1 IV 2392.]

Waste Disposal

DGME is mixed with a combustible solvent and burned in a chemical incinerator.