Ticlopidine hydrochloride
- Product Name
- Ticlopidine hydrochloride
- CAS No.
- 53885-35-1
- Chemical Name
- Ticlopidine hydrochloride
- Synonyms
- Soper;tiklid;53-32c;4-c-32;ticlid;Tiklyd;ticlodix;Iparazin;panaldine;ticlodone
- CBNumber
- CB0674371
- Molecular Formula
- C14H14ClNS.ClH
- Formula Weight
- 300.25
- MOL File
- 53885-35-1.mol
Ticlopidine hydrochloride Property
- Melting point:
- 205°C
- Density
- 1.37 g/cm3
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Sparingly soluble in water and in anhydrous ethanol, very slightly soluble in ethyl acetate.
- pka
- 7.64(at 25℃)
- form
- Solid
- color
- White
- Water Solubility
- Soluble to 100 mM in water and to 100 mM in DMSO.
- λmax
- 295nm(H2O)(lit.)
- Merck
- 14,9421
- CAS DataBase Reference
- 53885-35-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36-37/39-26
- WGK Germany
- 3
- RTECS
- XJ9089100
- HS Code
- 2934990002
- Toxicity
- LD50 in mice (mg/kg/24 hrs): 55 i.v.; >300 orally (Castaigne)
N-Bromosuccinimide Price
- Product number
- T6654
- Product name
- Ticlopidine hydrochloride
- Purity
- analytical standard, for drug analysis
- Packaging
- 1g
- Price
- $39.4
- Updated
- 2024/03/01
- Product number
- PHR3367
- Product name
- Ticlopidine hydrochloride
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 300MG
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 1667144
- Product name
- Ticlopidine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 150mg
- Price
- $261.6
- Updated
- 2024/03/01
- Product number
- T3110
- Product name
- Ticlopidine Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $61
- Updated
- 2024/03/01
- Product number
- T3110
- Product name
- Ticlopidine Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $159
- Updated
- 2024/03/01
Ticlopidine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Ticlid,Millot,France,1978
Uses
Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist. It inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.
Uses
An antithrombotic. a platelet aggregation inhibitor
Uses
mucolytic, antibacterial, surface active agent
Manufacturing Process
A solution of thieno[3,2-c]pyridine (13.5 g; 0.1 mol) and 2-chlorobenzyl
chloride (17.7 g) in acetonitrile (150 ml) is boiled during 4 hours.
After evaporation of the solvent, the solid residue consists of 5-(2-
chlorobenzyl)-thieno[3,2-c]pyridinium chloride which melts at 166°C
(derivative n° 30). This compound is taken up into a solution comprising
ethanol (300 ml) and water (100 ml). Sodium borohydride (NaBH4)(20 g) is
added portionwise to the solution maintained at room temperature. The
reaction medium is maintained under constant stirring during 12 hours and is
then evaporated. The residue is taken up into water and made acidic with
concentrated hydrochloric acid to destroy the excess reducing agent. The
mixture is then made alkaline with ammonia and extracted with ether. The
ether solution is washed with water, dried and evaporated. The oily residue is
dissolved in isopropanol (50 ml) and hydrochloric acid in ethanol solution is
then added thereto.
After filtration and recrystallization from ethanol, there are obtained 5-(2-
chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride crystals
(yield: 60%) having a melting point (Koefler block) of 190°C.
Therapeutic Function
Platelet aggregation inhibitor
Biological Activity
Selective P2Y 12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo .
Ticlopidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ticlopidine hydrochloride Suppliers
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- Country
- Europe
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View Lastest Price from Ticlopidine hydrochloride manufacturers
- Product
- Ticlopidine hydrochloride 53885-35-1
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kg
- Release date
- 2021-09-22
- Product
- Ticlopidine hydrochloride 53885-35-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-31
- Product
- Ticlopidine Hydrochloride 53885-35-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2024-08-20