ChemicalBook > CAS DataBase List > 3-Fluoro-4-nitroanisole

3-Fluoro-4-nitroanisole

Product Name
3-Fluoro-4-nitroanisole
CAS No.
446-38-8
Chemical Name
3-Fluoro-4-nitroanisole
Synonyms
2-Fluoro-4-methoxy-1-nitrobenzene;3-FLUORO-4-NITROANISOLE;Anisole, 3-fluoro-4-nitro-;3-Fluoro-4-nitroanisole 98%;2-Fluoro-4-methoxynitrobenzene;3-Fluor-4-nitrophenylmethylether;Benzene, 2-fluoro-4-methoxy-1-nitro-;2-FLUORO-4-(METHOXY-D3)-1-NITROBENZENE;5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene;2-Fluoro-4-methoxynitrobenzene[3-Fluoro-4-nitroanisole
CBNumber
CB0678203
Molecular Formula
C7H6FNO3
Formula Weight
171.13
MOL File
446-38-8.mol
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3-Fluoro-4-nitroanisole Property

Melting point:
57.3
Boiling point:
264.5±20.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
form 
crystalline solid
color 
Off-white
InChI
InChI=1S/C7H6FNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3
InChIKey
PLEJCMKVJYUUBA-UHFFFAOYSA-N
SMILES
C1([N+]([O-])=O)=CC=C(OC)C=C1F
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Safety

Hazard Codes 
Xi,C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
3261
Hazard Note 
Irritant/Keep Cold
HazardClass 
8
PackingGroup 
Ⅱ
HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1291
Product name
2-Fluoro-4-methoxy-1-nitrobenzene
Purity
min. 98.0 %
Packaging
5G
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
F1291
Product name
2-Fluoro-4-methoxy-1-nitrobenzene
Purity
min. 98.0 %
Packaging
25G
Price
$117
Updated
2025/07/31
TRC
Product number
F597585
Product name
3-Fluoro-4-nitroanisole
Packaging
100mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J94990
Product name
3-Fluoro-4-nitroanisole
Packaging
10g
Price
$49
Updated
2021/12/16
ChemScene
Product number
CS-D1687
Product name
Anisole,3-fluoro-4-nitro-
Packaging
25g
Price
$50
Updated
2021/12/16
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3-Fluoro-4-nitroanisole Chemical Properties,Usage,Production

Uses

3-Fluoro-4-nitroanisole is synthesizing new antiseptic-germicide, sterilant, and the important organic fluoride-containing intermediate of liquid crystal material.

Synthesis

394-41-2

74-88-4

446-38-8

3-Fluoro-4-nitrophenol (75 g, 0.48 mol) was dissolved in acetone (700 mL) and cooled in an ice water bath. Subsequently, 1,8-diazabicyclo[5,4,0]undec-7-ene (145 g, 0.96 mol) was added slowly over about 1 hour and the reaction was held for 5 minutes. Next, iodomethane (135 g, 0.96 mol) was added dropwise over 10 min. The reaction mixture was stirred at room temperature for 16 hours. After that, 1,8-diazabicyclo[5,4,0]undec-7-ene (73 g, 0.48 mol) and iodomethane (68 g, 0.48 mol) were added and the mixture was heated to 50 °C and maintained for 1 hour. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was concentrated and mixed with ethyl acetate and 1 M hydrochloric acid. The organic layer was washed sequentially with hydrochloric acid and aqueous sodium bicarbonate, concentrated and precipitated as a solid by stirring in a hexane solution of 1% ethyl acetate. Finally, the product 3-fluoro-4-nitroanisole (72 g, 88% yield) was collected and air dried.

References

[1] Chemistry - A European Journal, 2009, vol. 15, # 4, p. 885 - 900
[2] Chemistry - A European Journal, 2014, vol. 20, # 39, p. 12553 - 12558
[3] Patent: WO2004/76455, 2004, A1. Location in patent: Page 24
[4] Patent: US2007/232603, 2007, A1. Location in patent: Page/Page column 16
[5] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9599 - 9605

3-Fluoro-4-nitroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Fluoro-4-nitroanisole manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
3-Fluoro-4-nitroanisole 446-38-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-08-19
Shaanxi Dideu New Materials Co. Ltd
Product
3-Fluoro-4-nitroanisole 446-38-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-10
Shaanxi Dideu Medichem Co. Ltd
Product
3-Fluoro-4-nitroanisole 446-38-8
Price
US $1.00-28.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-07-29

446-38-8, 3-Fluoro-4-nitroanisoleRelated Search:

3-Fluoro-4-nitrobenzoic acid 1,2,3-Trifluoro-4-nitrobenzene 2-Fluoro-4-nitrobenzoic acid Sodium 3-nitrobenzenesulphonate 4-Nitrobenzoic acid 2,3-Difluoro-4-nitroanisole 4-BENZYLOXY-2-FLUORO-1-NITROBENZENE 4-ETHOXY-2-FLUORO-1-NITROBENZENE 5-FLUORO-2-NITROANISOLE,5-Fluoro-2-nitroanisole99% 4-Fluoro-2-nitroanisole98%,4-Fluoro-2-nitroanisole 98%,4-FLUORO-2-NITROANISOLE Nitrobenzene Fluorine 3-Nitroanisole 4-Nitroanisole 2-CHLORO-4-FLUORO-5-NITROANISOLE 3-Bromo-2-methoxy-5-trifluoromethylpyridine 2-BROMO-6-FLUORO-4-NITROANISOLE,1-Bromo-3-fluoro-2-methoxy-5-nitrobenzene, 2-Bromo-6-fluoro-4-nitroanisole 1,3-Dinitrobenzene

  • 3-FLUORO-4-NITROANISOLE
  • 2-Fluoro-4-methoxy-1-nitrobenzene
  • 2-Fluoro-4-methoxynitrobenzene
  • 2-Fluoro-4-methoxynitrobenzene, 3-Fluoro-4-nitrophenyl methyl ether
  • 3-Fluoro-4-nitroanisole 98%
  • Anisole, 3-fluoro-4-nitro-
  • Benzene, 2-fluoro-4-methoxy-1-nitro-
  • 3-Fluor-4-nitrophenylmethylether
  • 2-FLUORO-4-(METHOXY-D3)-1-NITROBENZENE
  • 2-Fluoro-4-methoxynitrobenzene[3-Fluoro-4-nitroanisole
  • 5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene
  • 446-38-8
  • blocks
  • FluoroCompounds
  • NitroCompounds
  • Aromatic Halides (substituted)
  • K00001