3-Aminobenzamide

ChemicalBook > CAS DataBase List > 3-Aminobenzamide

Product Name: 3-Aminobenzamide
CAS No.: 3544-24-9
Chemical Name: 3-Aminobenzamide
Synonyms: 3-AB;3-ABA;INO-1001;PARP-IN-1;3-AB, 3-ABA;3-amino-benzamid;M-AMINOBENZAMIDE;3-AMINOBENZAMIDE;m-amino-benzamid;Benzamide, m-amino-
CBNumber: CB0681621
Molecular Formula: C7H8N2O
Formula Weight: 136.15
MOL File: 3544-24-9.mol

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3-Aminobenzamide Property

Melting point:: 115-116 °C (lit.)
Boiling point:: 250.42°C (rough estimate)
Density: 1.1778 (rough estimate)
refractive index: 1.5769 (estimate)
storage temp.: room temp
solubility: ethanol: 50 mg/mL, clear, faintly yellow
form: powder
pka: 16.26±0.50(Predicted)
color: white to off-white
Water Solubility: Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
Sensitive: Light Sensitive
BRN: 2802373
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP: -0.330
CAS DataBase Reference: 3544-24-9(CAS DataBase Reference)
NIST Chemistry Reference: 3-NH2-C6H4CONH2(3544-24-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: 3077
WGK Germany: 3
RTECS: CU8992000
HS Code: 29242990
Hazardous Substances Data: 3544-24-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0788
Product name: 3-Aminobenzamide
Purity: ≥99% (TLC)
Packaging: 1g
Price: $432
Updated: 2024/03/01

Sigma-Aldrich

Product number: 165350
Product name: PARP Inhibitor I, 3-ABA
Packaging: 100mg
Price: $56.2
Updated: 2024/03/01

TCI Chemical

Product number: A0630
Product name: 3-Aminobenzamide
Purity: >98.0%(T)
Packaging: 5g
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: A0630
Product name: 3-Aminobenzamide
Purity: >98.0%(T)
Packaging: 25g
Price: $135
Updated: 2024/03/01

Alfa Aesar

Product number: A10793
Product name: 3-Aminobenzamide, 98%
Packaging: 5g
Price: $54.65
Updated: 2024/03/01

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3-Aminobenzamide Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (K_i = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

Chemical Properties

beige powder

Uses

The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

Uses

3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.

Definition

ChEBI: A substituted aniline that is benzamide in which one of the meta- hydrogens is replaced by an amino group.

Biochem/physiol Actions

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.

References

1) Purnell and Whish (1980), Novel inhibitors of poly(ADP-ribose) synthetase; Biochem. J., 185 775 2) Kuo et al. (1996), Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells; Biochem. Biophys. Res. Commun., 219 502 3) Malorni et al. (1995), 3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion; Biochem. Biophys. Res. Commun., 207 715 4) Heller et al. (1995), Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells; J. Biol. Chem., 270 11176

3-Aminobenzamide Preparation Products And Raw materials

Raw materials

Methanesulfonic acid Sodium sulfate Dichloromethane 3-Aminobenzonitrile Aluminum oxide

Preparation Products

3-NITROSOBENZAMIDE

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3-Aminobenzamide Suppliers

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View Lastest Price from 3-Aminobenzamide manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: 3-Aminobenzamide 3544-24-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-15

Hebei Guanlang Biotechnology Co,.LTD

Product: 3-Aminobenzamide 3544-24-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2022-01-25

Hebei Guanlang Biotechnology Co., Ltd.

Product: 3-Aminobenzamide 3544-24-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2022-12-13

3544-24-9, 3-AminobenzamideRelated Search:

Benzamide 3-Aminobenzoic acid Chlorantraniliprole Metrizamide 3,5-Dinitrobenzamide N-(4-Aminobutyl)-N-ethylisoluminol 4-AMINO-3,5-DINITROBENZAMIDE 4-Nitrophthalhydrazide (R)-(+)-1-(4-Methylphenyl)ethylamine 3-Nitrophthalhydrazide 2-AB, 2-Aminobenzamide,2-AMINOBENZAMIDE p-Aminobenzamide 4-Nitrophthalimide XYLIDYL BLUE I SODIUM SALT Luminol 4-Aminophthalhydrazide 2-[2-HYDROXY-3-(2,4-XYLYLCARBAMOYL)-1-NAPHTHYLAZO]PHENOL (R)-(-)-N-(3,5-DINITROBENZOYL)-ALPHA-PHENYLETHYLAMINE

M-AMINOBENZAMIDE

3-ABA

3-AMINOBENZAMIDE

PARP Inhibitor I, 3-ABA

PARP Inhibitor I, 3-ABA - CAS 3544-24-9 - Calbiochem

3-AMINOBENZAMIDE;INO1001;INO 1001

INO-1001 (3-Aminobenzamide

Aminobenzamide, 3- - AB, 3- | ABA, 3-

3-amino-benzamid

Benzamide, 3-amino-

Benzamide, m-amino-

m-amino-benzamid

3-AB

m-Amino Benzamide 3-Amino Benzamide

3-AB, 3-ABA

3-Aminobenzamide,3-AB, 3-ABA

INO-1001

3-AMinobenzaMide, 98% 1GR

3-AMinobenzaMide, 98% 5GR

Benzamide, 3-amino- (9CI)

3-Aminobenzamide,98%

META-AMINOBENZAMIDE

3-Aminobenzamide &gt

PARP-IN-1

PARP-IN-1 (3-aminobenzamide

3544-24-9

PARP

PARP Regulators

Organic Building Blocks

Building Blocks

Apoptosis and Cell Cycle

BioChemical

Amides

Cell Biology

Carbonyl Compounds

Cell Signaling and Neuroscience

A-AM

Amides

Bioactive Small Molecules

AMIDE

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Inhibitors

Inhibitor

Building Blocks

Carbonyl Compounds

Cell Biology

Chemical Synthesis

Organic Building Blocks