(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Uses

Product Name: (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 165528-81-4
Chemical Name: (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: 4-(2-Boc-aminoethyL;4-(BOC-AMINOETHYL)PIPERIDINE;4-(2-BOC-AMINOETHYL) PIPERIDINE;4-(N-BOC-2-AMINOETHYL)PIPERIDINE;4-(2-BOC-AMINOETHYL)-1-PIPERIDINE;4-(2-Aminothyl)piperidine,N2-BOC protected;TERT-BUTYL (2-PIPERIDIN-4-YLETHYL)CARBAMATE;4-(2-Aminoethyl)piperidine, 4-BOC protected;4-(2-Aminoethyl)piperidine, N2-BOC protected;tert-butyl N-[2-(piperidin-4-yl)ethyl]carbamate
CBNumber: CB0685412
Molecular Formula: C12H24N2O2
Formula Weight: 228.33
MOL File: 165528-81-4.mol

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(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 337.3±15.0 °C(Predicted)
Density: 0.971±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.86±0.46(Predicted)
form: liquid
color: Colourless to light yellow
InChI: InChI=1S/C12H24N2O2/c1-12(2,3)16-11(15)14-9-6-10-4-7-13-8-5-10/h10,13H,4-9H2,1-3H3,(H,14,15)
InChIKey: RQRMFFGCUUGYPC-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCC1CCNCC1
CAS DataBase Reference: 165528-81-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2933320000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B603355
Product name: 4-(2-Boc-aminoethyl)piperidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B603355
Product name: 4-(2-Boc-aminoethyl)piperidine
Packaging: 500mg
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB54370
Product name: 4-(2-Boc-aminoethyl)piperidine
Packaging: 500mg
Price: $40
Updated: 2021/12/16

Apolloscientific

Product number: OR2257
Product name: 4-(2-Aminoethyl)piperidine,4-BOCprotected
Packaging: 250mg
Price: $51
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB54370
Product name: 4-(2-Boc-aminoethyl)piperidine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

4-(2-BOC-aminoethyl)piperidine is mainly used as a pharmaceutical intermediate, and some literature reports that it can be used to prepare SHP2 inhibitors.

Synthesis

109573-05-9

165528-81-4

General procedure for the synthesis of 4-(2-Boc-aminoethyl)piperidine from tert-butyl N-[2-(pyridin-4-yl)ethyl]carbamate: tert-butyl N-[2-(pyridin-4-yl)ethyl]carbamate (26.9 g, 120.9 mmol) was dissolved in methanol (370 mL) and cooled to 0 °C. Aqueous 6N hydrochloric acid (20.2 mL, 120.9 mmol) was slowly added at 0 °C. Subsequently, platinum (IV) oxide (1.37 g, 6.05 mmol) was added to the reaction mixture at room temperature and the hydrogenation reaction was carried out under hydrogen (1000 psi) atmosphere for 24 hours. Upon completion of the reaction, the mixture was filtered through an Arbocel pad and the filter cake was washed sequentially with methanol (300 mL) and water (100 mL). The filtrate was concentrated under reduced pressure. The concentrated crude product was diluted with saturated aqueous sodium bicarbonate (150 mL) and extracted with dichloromethane (50 mL). The organic layer was washed with water (2 x 50 mL). The aqueous layers were combined, alkalized with 30% aqueous sodium hydroxide (30 mL) and then extracted with dichloromethane (8 x 200 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-(2-Boc-aminoethyl)piperidine as a clear viscous oil (26.8 g, 97% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) and LCMS: 1H NMR δ 1.17 (m, 2H), 1.41 (m, 10H), 1.68 (m, 2H), 2.58 (m, 2H), 3.09 (m, 6H), 4.53 (s, 1H); LCMS Rt = 1.73 min, MS m/z 229 [M + H ]+.

References

[1] Patent: WO2015/181797, 2015, A1. Location in patent: Page/Page column 132
[2] Patent: WO2004/87145, 2004, A2. Location in patent: Page/Page column 31
[3] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 9, p. 1317 - 1322
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 17, p. 2325 - 2330
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4116 - 4126

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER 165528-81-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER 165528-81-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

165528-81-4, (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

piperidine-4-propanol tert-butyl 2-(pyrrolidin-3-yl)ethylcarbamate N-Boc-N-methylethylenediamine Carbamic acid, [2-[(1-methylethyl)amino]ethyl]-, 1,1-dimethylethyl ester (9CI) N-[2-Chloro-3-formyl-4-pyridinyl]carbamic acid tert-butyl ester (2-PIPERIDIN-2-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER (2-PIPERIDIN-3-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER 2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 2,8-DIAZASPIRO[4.5]DECAN-2-CARBOXYLATE HYDROCHLORIDE 9-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE-3-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 3-PIPERIDIN-4-YLPYRROLIDINE-1-CARBOXYLATE 3-(1-Boc-piperidin-4-yl)-N-Boc-DL-alanine tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate Tert-butyl octahydro-2,7-naphthyridine-2(1H)-carboxylate Methyl-(2-piperidin-3-yl-ethyl)-carbamic acid tert-butyl ester (S)-(2-PIPERIDIN-3-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER (SR)-N-ALPHA-N'-BIS-(T-BUTYLOXYCARBONYL)-4-PIPERIDINYL-3-AMINO-BUTANOIC ACID, RACEMIC

TERT-BUTYL (2-PIPERIDIN-4-YLETHYL)CARBAMATE

4-(2-Aminoethyl)piperidine, N2-BOC protected

4-(2-BOC-AMINOETHYL)-1-PIPERIDINE

4-(2-BOC-AMINOETHYL) PIPERIDINE

4-(N-BOC-2-AMINOETHYL)PIPERIDINE

4-(BOC-AMINOETHYL)PIPERIDINE

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

4-(2-Aminoethyl)piperidine, 4-BOC protected

tert-Butyl [2-(piperidin-4-yl)ethyl]carbamate, N-(tert-Butoxycarbonyl)-2-(piperidin-4-yl)ethylamine

4-(2-Aminothyl)piperidine,N2-BOC protected

Carbamic acid, N-[2-(4-piperidinyl)ethyl]-, 1,1-dimethylethyl ester

tert-butyl N-[2-(piperidin-4-yl)ethyl]carbamate

4-(2-Boc-aminoethyL

165528-81-4

Benzothiophenes ,Benzopyrans ,Thiophenes

pharmacetical