ChemicalBook > CAS DataBase List > 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE

2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE

Product Name
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
CAS No.
532967-21-8
Chemical Name
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
Synonyms
CAS:532967-21-8;3,5-Difluoro-4-formylphenol;6-difluoro-4-hydroxybenzaldehyde;2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2,6-difluoro-4-hydroxy-;2,6-Difluoro-4-hydroxybenzaldehyde,95%;2,6-Difluoro-4-hydroxybenzaldehyde 98%;2,6-Difluoro-4-hydroxybenzaldehyde ,97%;Benzaldehyde, 2,6-difluoro-4-hydroxy- (9CI);2,6-difluoro-4-hydroxybenzaldehyde2,6-difluoro-4-hydroxybenzaldehyde
CBNumber
CB0687128
Molecular Formula
C7H4F2O2
Formula Weight
158.1
MOL File
532967-21-8.mol
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2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE Property

Melting point:
179-182℃
Boiling point:
252.6±35.0 °C(Predicted)
Density 
1.464±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder
pka
5.80±0.23(Predicted)
color 
Off-white to cream
Sensitive 
Air Sensitive
CAS DataBase Reference
532967-21-8
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Safety

Hazard Codes 
Xi
Risk Statements 
20-36/37/38
Safety Statements 
22-36/37/39-45
Hazard Note 
Irritant
HS Code 
29124990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D447438
Product name
2,6-Difluoro-4-hydroxybenzaldehyde
Packaging
1g
Price
$125
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-3-35
Product name
2,6-Difluoro-4-hydroxybenzaldehyde
Packaging
1g
Price
$128
Updated
2021/12/16
Apolloscientific
Product number
PC9940
Product name
2,6-Difluoro-4-hydroxybenzaldehyde
Purity
98%
Packaging
250mg
Price
$25
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-3-35
Product name
2,6-Difluoro-4-hydroxybenzaldehyde
Packaging
250mg
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
PC9940
Product name
2,6-Difluoro-4-hydroxybenzaldehyde
Purity
98%
Packaging
5g
Price
$180
Updated
2021/12/16
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2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Brown to red powder

Synthesis

68-12-2

532967-21-8

General procedure for the synthesis of 2,6-difluoro-4-hydroxybenzaldehyde from N,N-dimethylformamide: At -78 °C, sec-butyllithium (1.3 M cyclohexane solution, 53 mL, 69.3 mmol) was slowly added to intermediates 19,1-(tert-butyldimethylsilyl)oxy-3,5-difluorobenzene (15.3 g, 62.6 mmol) and TMEDA (10.5 mL, 69.3 mmol) in a solution of tetrahydrofuran (200 mL) and stirred for 30 min at a maintained temperature of -78 °C. Subsequently, DMF (5.33 mL, 69.3 mmol) was added at the same temperature and stirring was continued for 1.5 hours. After the reaction was completed, 10% aqueous hydrochloric acid was added to adjust the pH to 4-5 (~200 mL) and then stirred at room temperature for 12 hours. The aqueous layer was extracted with ethyl acetate (200 mL) and the organic layer was separated. The organic layer was washed sequentially with saturated aqueous sodium bicarbonate, added sodium bicarbonate followed by water, and then adjusted the pH to 3-4 with hydrochloric acid, separated the organic layer, washed with brine, dried with anhydrous sodium sulfate, and finally evaporated in vacuum to obtain 2,6-difluoro-4-hydroxybenzaldehyde (9.7 g, 97% yield, 61.3 mmol) as a white solid.1H NMR (DMSO-d6) data: δ 11.54 (br.s, 1H, OH), 10.00 (s, 1H, CHO), 6.50-6.57 (m, 2H, Ar-H).

References

[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 136-137

2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

3,5-Difluorophenol Potassium hydroxide Phosphorus oxitrichloride Chloroform Ethyl acetate PETROLEUM ETHER

Preparation Products

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2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE Suppliers

China 115 Europe 1 Germany 1 India 2 Italy 1 United Kingdom 8 United States 12 Global 140
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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60
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
021-31038972,31038973 17321035817
Fax
+86-21-51385350
Email
sales@harvest-chem.com
Country
China
ProdList
2816
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Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
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60
ChemShuttle, Inc.
Tel
0510-83588313-811 18800520310
Email
sales@chemshuttle.com
Country
China
ProdList
2999
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62
Shanghai yirong biology science and technology co., ltd
Tel
18049974220
Fax
+86 (21) 51062076
Email
3060526242@qq.com
Country
China
ProdList
995
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60
Tianjin Derchemist Science & Technology Co., Ltd.
Tel
22-58627059 13920586291
Fax
022-58620305
Email
zdcomcon@126.com
Country
China
ProdList
3829
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50
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
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58
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View Lastest Price from 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE 532967-21-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-10
Shaanxi Dideu Medichem Co. Ltd
Product
2,6-Difluoro-4-hydroxybenzaldehyde 532967-21-8
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-15
Career Henan Chemical Co
Product
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE 532967-21-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-07-03

532967-21-8, 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDERelated Search:

2,6-Difluoro-4-hydroxybenzoic acid 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 2,6-DIFLUORO-4-METHOXYBENZOIC ACID 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE 2',6'-DIFLUORO-4'-METHOXYACETOPHENONE 3,5-DIFLUORO-4-HYDROXYBENZALDEHYDE,3,5-Difluoro-4-hydroxybenzaldehyde 97%,3,5-Difluoro-4-hydroxybenzaldehyde97% 2,3-Difluoro-4-hydroxybenzaldehyde97% 2,6-DIFLUORO-4-METHOXYBENZAMIDE 2,3,5,6-TETRAFLUORO-4-HYDROXYBENZOIC ACID HYDRATE 4-ACETOXY-2,3,5,6-TETRAFLUOROBENZOIC ACID 3,6-DIFLUORO-2-HYDROXYBENZALDEHYDE 2,3-DIFLUORO-6-HYDROXYBENZALDEHYDE 4,5-DIFLUORO-2-HYDROXYBENZALDEHYDE 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE OXIME 2,5-DIFLUORO-4-HYDROXYBENZALDEHYDE 2,6-DIFLUORO-3-HYDROXYBENZALDEHYDE 3,4-DIFLUORO-2-HYDROXYBENZALDEHYDE 2,6-DIFLUORO-4-METHOXYBENZOYL CHLORIDE

  • 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
  • Benzaldehyde, 2,6-difluoro-4-hydroxy- (9CI)
  • 3,5-Difluoro-4-formylphenol
  • 6-difluoro-4-hydroxybenzaldehyde
  • 2,6-Difluoro-4-hydroxybenzaldehyde ,97%
  • 2,6-difluoro-4-hydroxybenzaldehyde2,6-difluoro-4-hydroxybenzaldehyde
  • 2,6-Difluoro-4-hydroxybenzaldehyde 98%
  • Benzaldehyde, 2,6-difluoro-4-hydroxy-
  • 2,6-Difluoro-4-hydroxybenzaldehyde,95%
  • CAS:532967-21-8
  • 532967-21-8
  • ALDEHYDE
  • ALCOHOL
  • HALIDE
  • Aromatic Aldehydes & Derivatives (substituted)