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2-Amino-3,5-dibromobenzaldehyde

Product Name
2-Amino-3,5-dibromobenzaldehyde
CAS No.
50910-55-9
Chemical Name
2-Amino-3,5-dibromobenzaldehyde
Synonyms
3,5-DIBROMOANTHRALDEHYDE;2-AMino-3;Ambroxol-5;5-dibroMobenzaldehyde;BroMhexine IMpurity B;Bromhexine Impurity Ⅱ;Ambroxol EP Impurity E;BroMhexine EP IMpurity B;3,5-DIBROMANTHRANILALDEHYD;3,5-DIBROMOANTHRANILALDEHYDE
CBNumber
CB0689243
Molecular Formula
C7H5Br2NO
Formula Weight
278.93
MOL File
50910-55-9.mol
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2-Amino-3,5-dibromobenzaldehyde Property

Melting point:
130-135 °C (lit.)
Boiling point:
319.9±42.0 °C(Predicted)
Density 
2.0123 (rough estimate)
refractive index 
1.6400 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
-2.29±0.10(Predicted)
color 
Yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H5Br2NO/c8-5-1-4(3-11)7(10)6(9)2-5/h1-3H,10H2
InChIKey
RCPAZWISSAVDEA-UHFFFAOYSA-N
SMILES
C(=O)C1=CC(Br)=CC(Br)=C1N
CAS DataBase Reference
50910-55-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
37/39-26-36
WGK Germany 
3
HS Code 
29223990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
463469
Product name
2-Amino-3,5-dibromobenzaldehyde
Purity
97%
Packaging
5g
Price
$84.5
Updated
2025/07/31
Sigma-Aldrich
Product number
463469
Product name
2-Amino-3,5-dibromobenzaldehyde
Purity
97%
Packaging
25g
Price
$150
Updated
2023/06/20
TCI Chemical
Product number
D2625
Product name
3,5-Dibromoanthranilaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
D2625
Product name
3,5-Dibromoanthranilaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$45
Updated
2025/07/31
TRC
Product number
A604610
Product name
2-Amino-3,5-dibromo-benzaldehyde
Packaging
25g
Price
$245
Updated
2021/12/16
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2-Amino-3,5-dibromobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

Yellow crystalline powder

Uses

2-Amino-3,5-dibromobenzaldehyde may be employed in the preparation of tetradentate Schiff base ligands, via condensation with aliphatic diamines. These ligands forms nickel (II) and oxovanadium(IV) complexes.

Uses

2-Amino-3,5-dibromobenzaldehyde is a reagent used in the preparation of Ambroxol and Bromhexine (B678600) metabolites.

General Description

2-Amino-3,5-dibromobenzaldehyde has been identified as one of the oxidation product of bromhexine by controlled potential electrolysis followed by HPLC-UV and GC-MS. It participates in the Friedl?nder condensation of C-β?glycosylic ketones to form 2-substituted quinoline derivatives.

Synthesis

529-23-7

50910-55-9

(1) Mix ethanol, water and o-aminobenzaldehyde with stirring at a molar ratio of 4:1:0.2. Elevate the temperature until the solid o-aminobenzaldehyde was completely dissolved; (2) add reduced iron powder, add 3 to 5 drops of hydrochloric acid, stir thoroughly, continue to elevate the temperature until the reaction system reached the reflux temperature, keep stirring the reaction, and monitor the progress of the reaction using high-performance liquid chromatography (HPLC); (3) after completion of the reaction, the reaction solution was filtered, and a mixture of bromine, potassium bromide, and water was added slowly to the filtrate by dropwise addition, and after completion of the dropwise addition, the Maintain the temperature and continue to stir the reaction; (4) add an excess of saturated sodium bicarbonate solution to the reaction mixture, stir well, precipitate a solid, and filter to obtain 2-amino-3,5-dibromobenzaldehyde. In this embodiment, the molar ratio of o-aminobenzaldehyde, bromine and potassium bromide was 1:1.93:9.5. The yield of 2-amino-3,5-dibromobenzaldehyde was 91.1% and the purity was 99.4%.

References

[1] Patent: CN107488121, 2017, A. Location in patent: Paragraph 0017; 0018; 0019; 0020-0023; 0025-0030; 0032-0037
[2] Patent: CN107488124, 2017, A. Location in patent: Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0038
[3] Australian Journal of Chemistry, 1980, vol. 33, # 1, p. 91 - 99
[4] Patent: CN107488126, 2017, A. Location in patent: Paragraph 0018-0024; 0027-0031; 0034-0038
[5] Chemische Berichte, 1901, vol. 34, p. 1338

2-Amino-3,5-dibromobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3,5-dibromobenzaldehyde Suppliers

Americas 1 Belgium 2 Canada 3 China 450 Europe 3 Germany 10 India 79 Japan 5 Slovakia 1 South Korea 3 Switzerland 3 Ukraine 1 United Kingdom 16 United States 44 Global 621
Guangzhou Greensyn Co., Ltd.
Tel
00000
Email
luojunjian@greensyn.com
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China
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yxinchem
Tel
+86-0710-4323688 +86-18071785587
Fax
15502706050
Email
market@yxinchem.com
Country
China
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Shanghai Qiao Chemical Science Co., Ltd
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021-58892003
Email
info@qiaochem.com
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China
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6059
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Shanghai jing Hao pharmaceutical technology co., LTD
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021-68900963 15618693615
Fax
021-68900963
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sales@jinghaopharma.com
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China
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Shanghai Witofly Chemical Co. ,Ltd.
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021-50630626 18964684208
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sales@witofly.com
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China
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Jinan Dexinjia Bio&Tech Co., Ltd
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0531-82371986 15269101859
Fax
0531-82375893
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3276840968@qq.com
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China
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LGC Science (Shanghai) Ltd.
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17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
18003
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Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
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0513-82104991 18912868361
Fax
QQ1907456386
Email
sales11@btcpharm.com
Country
China
ProdList
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Z IntellecChem & Tech. Co., Ltd
Tel
15050866711
Fax
QQ:2677337387
Email
contact@zintellec.com
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
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View Lastest Price from 2-Amino-3,5-dibromobenzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-3,5-dibromobenzaldehyde 50910-55-9
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-3,5-dibromobenzaldehyde 50910-55-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-11
Hebei Yanxi Chemical Co., Ltd.
Product
2-Amino-3,5-dibromobenzaldehyde 50910-55-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-07

50910-55-9, 2-Amino-3,5-dibromobenzaldehydeRelated Search:

Glycine 2,3-Dibromopropionic acid p-Anisaldehyde 2-Aminobenzaldehyde 6-Aminocaproic acid Benzaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE 4-Hydroxybenzaldehyde 3-(Trifluoromethyl)benzaldehyde ALTRENOGEST 2-Nitrobenzaldehyde 3-Aminophenol 4-Dimethylaminobenzaldehyde 2-AMINO-3,5-DIBROMOBENZYL ALCOHOL Bromhexine Hydrochloride Impurity I Tris(hydroxymethyl)aminomethane 1-Amino-2,4-dibromoanthraquinone Vat Blue 4B

  • 3,5-DIBROMOANTHRALDEHYDE
  • 3,5-DIBROMOANTHRANILALDEHYDE
  • 3,5-DIBROMANTHRANILALDEHYD
  • 2-AMINO-3,5-DIBROMOBENZALDEHYDE
  • 3,5-Dibromo-2-aminobenzaldehyde
  • 2-AMINO-3,5-DIBROMOBENZALDEHYDE 98+%
  • 2-Amino-3,5-Bromo Benzaldehyde
  • 2-AMINO-3,5-DIBROMOBENZALDEHYDE=3,5-DIBROMOANTHRANILALDEHYDE
  • Benzaldehyde, 2-amino-3,5-dibromo-
  • 2-Amino-3,5-dibromobenzaldehyde,97%
  • 3,5-Dibromobenzaldehyde-2-Amino
  • 3,5-Dibromo-O-Aminobenzaldehyde
  • Bromhexine Impurity 2（EP Impurity B）
  • Ambroxol-5
  • Ambroxol Impurity 2（Ambroxol EP Impurity E）
  • 2-AMino-3
  • 5-dibroMobenzaldehyde
  • 2-AMino-3,5-dibroMobenzaldehyde, 97% 5GR
  • BroMhexine EP IMpurity B
  • BroMhexine IMpurity B
  • 3,5-DibroMoanthranilaldehyde, 98.0%(GC)
  • Ambroxol EP Impurity E
  • Ambroxol impurity EP impurity E
  • 2-amio-3,5-dibromobenzaldehyde
  • Bromhexine Impurity Ⅱ
  • Dibromoanthranilaldehyde Dibromoanthranilaldehyde
  • Ambroxol EP Impurity E (Bromhexine EP Impurity B)
  • 3,5-Dibromoanthranilaldehyde&gt
  • Ambroxol hydrochloride Imp. E (Bromhexine EP Impurity B)
  • 2-AMINO-3,5-DIBROMO BENZALDEHYDE (ADBA)
  • 2-Amino-3,5-dibrombenzaldehyd
  • Bromhexine EP Impurity B (Ambroxol EP Impurity E)
  • Bromhexine Impurity 2（Bromhexine EP Impurity B）
  • 2-Amino-3,5-dibromobenzaldehyde (Ambroxol Impurity)
  • Ambroxol EP Impurity EQ: What is Ambroxol EP Impurity E Q: What is the CAS Number of Ambroxol EP Impurity E Q: What is the storage condition of Ambroxol EP Impurity E Q: What are the applications of Ambroxol EP Impurity E
  • 3-methyl-1-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-1,4
  • 3,5-Dibromo-2-aminobenChemicalbookzaldehyde
  • Ambroxol Hydrochloride EP Impurity E
  • 2-Amino-3,5-dirbomobenzaldehyde
  • Bromhexine Hydrochloride EP Impurity B
  • Ambroxol EP Impurity E/Bromhexine hydrochloride EP impurity B
  • 2-Amino-3,5-dibomobenzaldehyde (ADBA)
  • 2 mino-3,5-dibromobenzaldehyde
  • BroMhexine IMpurity B, 10 mM in DMSO
  • 50910-55-9
  • 84477-98-7
  • C7H5Br2NO4
  • C7H5NOBr2
  • H2NC6H2Br2CHO
  • Organic Building Blocks
  • Carbonyl Compounds
  • C7
  • Aldehydes
  • Building Blocks
  • Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities