2-Amino-5-bromobenzotrifluoride

Product Name: 2-Amino-5-bromobenzotrifluoride
CAS No.: 445-02-3
Chemical Name: 2-Amino-5-bromobenzotrifluoride
Synonyms: 2-Amino-5-bromobenzo;4-bromo-2-trifluoroaniline;2-AMINO-5-BROMOBENZOTRIFLUORIDE;2-amino-5-bromotrifluorotoluene;2-Amino-5-bromotrifluorobenzene;4-BROMO-2-(TRIFLUOROMETHYL)ANILINE;4-bromo-2-(Trilfuoromethyl)aniline;2-Amino-5-bromobenzotrifluoride98%;2-(Trifluoromethyl)-4-bromoaniline;2-Amino-5-bromobenzotrifluoride 98%
CBNumber: CB0691790
Molecular Formula: C7H5BrF3N
Formula Weight: 240.02
MOL File: 445-02-3.mol

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2-Amino-5-bromobenzotrifluoride Property

Melting point:: 84～86℃/5mm
Boiling point:: 84-86 °C5 mm Hg(lit.)
Density: 1.71 g/mL at 25 °C(lit.)
refractive index: n20/D 1.532(lit.)
Flash point:: 225 °F
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: clear liquid
pka: 0.76±0.10(Predicted)
Specific Gravity: 1.71
color: Light yellow to Yellow to Orange
BRN: 2211504
InChIKey: PHXGKHTWEOPCEW-UHFFFAOYSA-N
CAS DataBase Reference: 445-02-3(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 4-bromo-2-(trifluoromethyl)-(445-02-3)
EPA Substance Registry System: 4-Bromo-2-(trifluoromethyl)aniline (445-02-3)

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Safety

Hazard Codes: Xn,Xi,C
Risk Statements: 20/21/22-36/37/38-34
Safety Statements: 26-36-36/37/39-45-27
WGK Germany: 3
Hazard Note: Irritant
TSCA: T
HazardClass: 6.1
HS Code: 29214300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 297704
Product name: 4-Bromo-2-(trifluoromethyl)aniline
Purity: 97%
Packaging: 5g
Price: $29.9
Updated: 2023/06/20

TCI Chemical

Product number: A1056
Product name: 2-Amino-5-bromobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: A1056
Product name: 2-Amino-5-bromobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 25g
Price: $122
Updated: 2025/07/31

Usbiological

Product number: 260243
Product name: 2-Amino-5-bromobenzotrifluoride
Packaging: 50g
Price: $206
Updated: 2021/12/16

TRC

Product number: A594200
Product name: 2-Amino-5-bromobenzotrifluoride
Packaging: 100g
Price: $250
Updated: 2021/12/16

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2-Amino-5-bromobenzotrifluoride Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Uses

4-Bromo-2-(trifluoromethyl)aniline has been used in the preparation of 2,5-dibromo-(trifluoromethyl)benzene and 5-bromo-2-iodo-(trifluoromethyl)benzene.

Uses

2-Amino-5-bromobenzotrifluoride is a reagent used for the synthesis of α-aminophosphonate which exhibits moderate antitumor activity.

Synthesis

887144-94-7

106-40-1

445-02-3

The general procedure for the synthesis of 2-amino-5-bromobenzotrifluoride from 1-(trifluoromethyl)-1,2-phenyliodo-3(1H)-one and 4-bromoaniline is as follows: in this embodiment, the same reaction and post-processing procedure as in Example 28 is used, wherein the aromatic amine is p-bromoaniline. The specific reaction conditions were as follows: 1-(trifluoromethyl)-1,2-phenyl iodo-3(1H)-one (0.5 mmol, 1.0 eq.), aromatic amine (1.5 mmol, 3.0 eq.), nickel hydroxide (10 μmol), and potassium carbonate (1.5 mmol, 3.0 eq.) were used as a base, and the reaction was carried out for 2 hours at 35°C in DMSO (2 mL). After the reaction was completed, post-treatment was performed according to the method of Example 1.

References

[1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0232-0236
[3] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771
[4] Patent: CN103553857, 2016, B. Location in patent: Paragraph 0019-0020

2-Amino-5-bromobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-bromobenzotrifluoride Suppliers

Americas 1 Belgium 1 China 252 Europe 3 France 1 Germany 4 India 17 Italy 1 Japan 2 Switzerland 2 Ukraine 1 United Kingdom 23 United States 40 Global 348

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View Lastest Price from 2-Amino-5-bromobenzotrifluoride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-5-bromobenzotrifluoride 445-02-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-5-bromobenzotrifluoride 445-02-3
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

Hangzhou ICH Biofarm Co., Ltd

Product: 4-Bromo-2-(Trifluoromethyl)aniline 445-02-3
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 20000kg
Release date: 2023-06-28

445-02-3, 2-Amino-5-bromobenzotrifluorideRelated Search:

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2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE

2-AMINO-5-BROMOBENZOTRIFLUORIDE

4-BROMO-2-(TRIFLUOROMETHYL)ANILINE

4-Bromo-alpha,alpha,alpha-trifluoro-o-toluidine

4-bromo-2-(trifluoromethyl)-benzenamin

2-Amino-5-bromobenzotrifluoride 98%

2-Amino-5-bromobenzotrifluoride98%

4-bromo-2-(Trilfuoromethyl)aniline

o-Toluidine, 4-bromo-alpha,alpha,alpha-trifluoro-

2-Amino-5-bromobenzotrifluoride, 98% (4-Bromo-2-trifluoromethylaniline)

4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 97%

2-Amino-5-bromobenzo

para-broMo ortho-trifluoroMethyl aniline

2-(Trifluoromethyl)-4-bromoaniline

2-Amino-5-bromobenzotrifluoride,97%

BenzenaMine, 4-broMo-2-(trifluoroMethyl)-

4-Bromo-2-(trifluoromethyl)aniline, 4-Bromo-alpha,alpha,alpha-trifluoro-o-toluidine

2-AMino-5-broMobenzotrifluoride[4-BroMo-2-(trifluoroMethyl)aniline]

2-amino-5-bromotrifluorotoluene

2-Amino-5-bromotrifluorobenzene

2-Amino-5-bromobenzotrifluoride &gt

4-bromo-2-trifluoroaniline

4-Bromo-2-trifluoromethylphenylamine

4-Bromo-2-(trifluoromethyl)aniline, 97%

445-02-3

455-02-3

C7H5BrF3N

Nitrogen Compounds

Organic Building Blocks

Building Blocks

Amines

C7

Amines

C7

Nitrogen Compounds

Aniline

Benzotrifluoride Series

Aromatic Halides (substituted)

Trifluoromethylbenzene serise