3,5-Bis(trifluoromethyl)bromobenzene

Product Name: 3,5-Bis(trifluoromethyl)bromobenzene
CAS No.: 328-70-1
Chemical Name: 3,5-Bis(trifluoromethyl)bromobenzene
Synonyms: 1-BROMO-3,5-BIS(TRIFLUOROMETHYL)BENZENE;3,5-BIS(TRIFLUOROMETHYL)-1-BROMOBENZENE;1,3-BIS(TRIFLUOROMETHYL)-5-BROMOBENZENE;3,5-Bis(trifluoromethyl)phenyl bromide;MBT-BR;1,3-Bis(trifL;1-BROMO-3,5-BIS;)-5-bromobenzene;TRIFLUOROMETHYL BROMOBENZENE;3,5-Bis(trifluoromethly)b...
CBNumber: CB4137843
Molecular Formula: C8H3BrF6
Formula Weight: 293
MOL File: 328-70-1.mol

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3,5-Bis(trifluoromethyl)bromobenzene Property

Melting point:: −16 °C(lit.)
Boiling point:: 154 °C(lit.)
Density: 1.699 g/mL at 25 °C(lit.)
refractive index: n20/D 1.427(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Sparingly)
form: Liquid
Specific Gravity: 1.699
color: Clear colorless to slightly yellow
Water Solubility: Immiscible with water.
BRN: 2123669
InChIKey: CSVCVIHEBDJTCJ-UHFFFAOYSA-N
CAS DataBase Reference: 328-70-1(CAS DataBase Reference)
NIST Chemistry Reference: 3,5-Bis(trifluoromethyl)bromobenzene(328-70-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29036990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290157
Product name: 1,3-Bis(trifluoromethyl)-5-bromobenzene
Purity: 99%
Packaging: 10g
Price: $60.41
Updated: 2025/07/31

Sigma-Aldrich

Product number: 290157
Product name: 1,3-Bis(trifluoromethyl)-5-bromobenzene
Purity: 99%
Packaging: 50g
Price: $149.41
Updated: 2025/07/31

TCI Chemical

Product number: B1753
Product name: 1-Bromo-3,5-bis(trifluoromethyl)benzene
Purity: >98.0%(GC)
Packaging: 10g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B1753
Product name: 1-Bromo-3,5-bis(trifluoromethyl)benzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $29
Updated: 2025/07/31

TRC

Product number: B412888
Product name: 3,5-Bis(trifluoromethyl)bromobenzene
Packaging: 5g
Price: $75
Updated: 2021/12/16

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3,5-Bis(trifluoromethyl)bromobenzene Chemical Properties,Usage,Production

Chemical Properties

clear colourless to slightly yellow liquid

Uses

1,3-Bis(trifluoromethyl)-5-bromobenzene is used to prepare the tetrakis[3,5-bis(trifluoromethyl)phenyl]borate ion, which acts as a stabilizing counterion for electrophilic organic and organometallic cations.

Synthesis Reference(s)

The Journal of Organic Chemistry, 68, p. 3695, 2003 DOI: 10.1021/jo026903n

Synthesis

402-31-3

328-70-1

Example 1: 1,3-bis(trifluoromethyl)benzene (1 kg) was slowly added to concentrated sulfuric acid (4 kg) while stirring the reaction mixture. The mixture was cooled to 5°C and 1,3-dibromo-5,5-dimethylglycolide (DBDMH, 668g) was added in batches over a period of 4 hours while maintaining the temperature between 0°C and 10°C. After completion of the reaction, the mixture was allowed to stand and layered to separate the organic phase. The organic phase was washed sequentially with water and dilute sodium bisulfite solution to remove residual acid and oxidants. Finally, the organic phase was purified by fractional distillation to afford 3,5-bis(trifluoromethyl)bromobenzene (1100 g, 99% purity, 80% yield).

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 9, p. 3695 - 3698
[2] Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 1.2, p. 108 - 112
[3] Zhurnal Organicheskoi Khimii, 1991, vol. 27, # 1, p. 125 - 129
[4] Tetrahedron Letters, 1998, vol. 39, # 52, p. 9621 - 9622
[5] Synlett, 1999, # 8, p. 1245 - 1246

3,5-Bis(trifluoromethyl)bromobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Bis(trifluoromethyl)bromobenzene Suppliers

Americas 1 Belgium 1 China 425 Europe 3 France 2 Germany 5 India 12 Italy 1 Japan 7 Jordan 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 25 United States 50 Global 539

CHANGZHOU FLUORIDE CHEMICAL CO.,LTD

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View Lastest Price from 3,5-Bis(trifluoromethyl)bromobenzene manufacturers

Sichuan Zhuoyu Yantang Technology Co., Ltd.

Product: 3,5-Bis(trifluoromethyl)bromobenzene 328-70-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2025-09-18

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-Bis(trifluoromethyl)bromobenzene 328-70-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,5-Bis(trifluoromethyl)bromobenzene 328-70-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-12

328-70-1, 3,5-Bis(trifluoromethyl)bromobenzeneRelated Search:

4-Bromobenzotrifluoride Xylene Trifluoromethanesulfonic acid 2-Bromofluorobenzene 2-Methylbenzotrifluoride 4-Bromofluorobenzene 2-(Trifluoromethyl)benzoic acid 3-Bromobenzotrifluoride Bromobenzene 3-Aminobenzotrifluoride 3-(Trifluoromethyl)benzaldehyde 3,5-Bis(trifluoromethyl)benzoic acid 2-Amino-5-bromobenzotrifluoride 3,5-Bis(trifluoromethyl)benzoyl chloride Benzene 3-METHYLBENZOTRIFLUORIDE 1,1-Difluoroethane Bromine

TRIFLUOROMETHYL BROMOBENZENE

1-Bromo-3,5-bis(trifluoromethyl)benzene, 3,5-Bis(trifluoromethyl)bromobenzene

3,5-Bis(trifluoromethyl)phenyl bromide

1-BROMO-3,5-BIS

3,5-Bis(trifluoromethyl)-5-bromobenzene ,99%

3,5-Bis(trifluoromethly)b...

3,5-Bis(trifluoroMethly)broMobenzene

3,5-Bis(trifluoroMethyl)broMobenzene, 99% 10GR

3,5-Bis(trifluoroMethyl)broMobenzene, 99% 50GR

1,3-Bis(trifluoromethyl)-5-bromobenzene 99%

5-Bromo-alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-m-xylene

1,3-Bis(trifluoroMethyl)-5-broMobenzene, 97+%

3,5-2,5-bis(trifluoromethyl)bromobenzene

3,5-bis-trifluoromethyl benzene bromide

3,5-Bis(trifluoromethyl)-1-bromobenzene for synthesis

MBT-BR

5-BROMO-1,3-BIS(TRIFLUOROMETHYL)BENZENE

3,5-BIS(TRIFLUOROMETHYL)BROMINE BENZENE

3,5-BIS(TRIFLUOROMETHYL)BROMOBENZENE

3,5-BIS(TRIFLUOROMETHYL)-1-BROMOBENZENE

3,5-DI(TRIFLUOROMETHYL)BROMOBENZENE

1,3-BIS(TRIFLUOROMETHYL)-5-BROMOBENZENE

1-BROMO-3,5-BIS(TRIFLUOROMETHYL)BENZENE

Benzene, 1-bromo-3,5-bis(trifluoromethyl)-

m-Xylene, 5-bromo-alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-

3,5-BIS(TRIFLUOROMETHYL)BROMOBENZENE, 99 %

3,5-Bis(Trifluoromethyl)-Bromo

3,5-BIS(TRIFLUOROMETHYL)BROMOBENZENE 98.00%

)-5-bromobenzene

1,3-Bis(trifL

3,5-Bis(trifluoromethyl)bromobenzene （Aprepitant）

1-Bromo-3,5-bis(trifluoromethyl)benzene &gt

1-Brom-3,5-bis(trifluormethyl)benzol

3,5-Bis(trifluoromethyl)bromobenzene ISO 9001：2015 REACH

5-Bis(trifluoromethyl)bromobenzene

3,5-Bis(trifluormethyl)bromobenzene

3,5-difluoromethylbromobenzene

328-70-1

CF32C6H3Br

C8H3BrF6

ARYL HALIDE

C8

Aryl

Building Blocks

Halogenated Hydrocarbons

Organic Building Blocks

Fluorobenzene

PHARMACEUTICAL INTERMEDIATES

Aromatic Hydrocarbons (substituted) & Derivatives

Fluorides

Trifluoromethylbenzene serise

alkyl bromide

Morpholines/Thiomorpholines ,Isoxazoles

API intermediates

Miscellaneous

bc0001