Ethyl 4-hydroxy-3-methoxybenzoate

Product Name: Ethyl 4-hydroxy-3-methoxybenzoate
CAS No.: 617-05-0
Chemical Name: Ethyl 4-hydroxy-3-methoxybenzoate
Synonyms: ERLOTINIBIM-U;ERLOTINIBIM-D;Ethyl Vanillat;Ethyl vanilate;2-Iodoanilline;ETHYL VANILLATE;Ethylvanillate,97%;RARECHEM AL BI 0101;TIMTEC-BB SBB005892;VANILIC ACID ETHYL ESTER
CBNumber: CB0704344
Molecular Formula: C10H12O4
Formula Weight: 196.2
MOL File: 617-05-0.mol

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Ethyl 4-hydroxy-3-methoxybenzoate Property

Melting point:: 43-45°C
Boiling point:: 108-110 °C (2 mmHg)
Density: 1.2166 (rough estimate)
refractive index: 1.5430 (estimate)
Flash point:: 293°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8.36±0.18(Predicted)
form: Solid
color: White to Off-White
Odor: at 100.00 %. phenolic burnt guaiacol smoky powdery metallic
Odor Type: phenolic
BRN: 2100025
InChIKey: MWAYRGBWOVHDDZ-UHFFFAOYSA-N
LogP: 2.741 (est)
CAS DataBase Reference: 617-05-0(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 4-hydroxy-3-methoxy-, ethyl ester(617-05-0)
EPA Substance Registry System: Benzoic acid, 4-hydroxy-3-methoxy-, ethyl ester (617-05-0)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-24/25-26
WGK Germany: 3
RTECS: YW5425000
TSCA: Yes
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S459267
Product name: ETHYL VANILLATE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S459267
Product name: ETHYL VANILLATE
Purity: Aldrich
Packaging: 50mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: V0051
Product name: Ethyl Vanillate
Purity: >98.0%(GC)
Packaging: 25g
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: V0051
Product name: Ethyl Vanillate
Purity: >98.0%(GC)
Packaging: 250g
Price: $636
Updated: 2022/04/27

TRC

Product number: E931978
Product name: Ethyl vanillate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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Ethyl 4-hydroxy-3-methoxybenzoate Chemical Properties,Usage,Production

Chemical Properties

Solid. Insoluble in water; soluble in alcohol and ether.

Uses

Food preservative, medicine, sunburn preventive.

Definition

ChEBI: Ethyl vanillate is a methoxybenzoic acid.

Synthesis

64-17-5

121-34-6

617-05-0

Synthesis of ethyl 4-hydroxy-3-methoxybenzoate: In a round-bottomed flask equipped with a nitrogen inlet and a magnetic stirrer, a solution of vanillic acid (10 g, 59.49 mmol) in anhydrous ethanol (400 mL) was added. Concentrated hydrochloric acid (600 mg, 6.11 mmol) was slowly added to the above solution, followed by dropwise addition of concentrated sulfuric acid. The reaction mixture was stirred under reflux conditions for 48 hours. After completion of the reaction, the solvent was removed using a rotary evaporator. Deionized water (100 mL) was added to the residue, and the green oily material was separated and discarded through a partition funnel. The resulting product was dried under vacuum to afford ethyl 4-hydroxy-3-methoxybenzoate (11.45 g, 98% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.62 (dd, J = 8.5, 2.1 Hz, 1H), 7.53 (d, J = 1.8 Hz, 1H), 6.91 (d, J = 8.6 Hz, 1H), 4.33 (q, J = 7.1 Hz, 2H), 3.91 (s, 3H), 1.36 (t, J = 7.3 Hz, 3H). Hz, 3H).HPLC-MS analysis showed the expected molecular ion peak m/z 197 (MH+) and measured m/z 197.

References

[1] Patent: WO2017/62804, 2017, A1. Location in patent: Paragraph 0070
[2] Patent: WO2018/144900, 2018, A1. Location in patent: Page/Page column 47-48
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 13, p. 4279 - 4290
[4] Chemische Berichte, 1877, vol. 10, p. 60 Anm.
[5] Molecular crystals and liquid crystals, 1982, vol. 99, # 1-4, p. 279 - 284

Ethyl 4-hydroxy-3-methoxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4-hydroxy-3-methoxybenzoate Suppliers

China 195 Europe 3 Germany 3 India 9 Japan 2 United Kingdom 8 United States 29 USA 1 Global 250

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View Lastest Price from Ethyl 4-hydroxy-3-methoxybenzoate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 4-hydroxy-3-methoxybenzoate 617-05-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-11

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Ethyl 4-hydroxy-3-methoxybenzoate 617-05-0
Price: US $55.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-21

Honest Joy Holdings Limited

Product: Ethyl vanillate 617-05-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.5%
Supply Ability: 100 tons
Release date: 2022-02-20

617-05-0, Ethyl 4-hydroxy-3-methoxybenzoateRelated Search:

Vanillic acid Tocoretinate Methyl vanillate Vanillylidenacetone Coumalic acid 2-(2-OXO-2H-CHROMEN-3-YL)ACETIC ACID Ethyl 3,4,5-trimethoxybenzoate Reserpine Deserpidine SYROSINGOPINE Ethyl 4-hydroxy-3-methoxybenzoate ETHYL 2-AMINO-4,5-DIMETHOXYBENZOATE Tannic acid Picroside II ETHYL 3,4-DIMETHOXYBENZOATE ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE 3-Methoxybenzoic acid ETHYL 3-METHOXYBENZOATE

TIMTEC-BB SBB005892

RARECHEM AL BI 0101

4-hydroxy-3-methoxy-benzoicaciethylester

4-hydroxy-m-anisicaciethylester

Vanillic Acid Ethyl Ester 4-Hydroxy-3-methoxybenzoic Acid Ethyl Ester Ethyl 4-Hydroxy-3-methoxybenzoate

4-Hydroxy-3-methoxybenzoic Acid Ethyl Ester Ethyl 4-Hydroxy-3-methoxybenzoate Vanillic Acid Ethyl Ester

Ethyl Vanillat

ERLOTINIBIM-D

ERLOTINIBIM-U

2-ethyl-4-hydroxy-3-methoxybenzoate

VANILLIC ACID ETHYL ESTER

VANILIC ACID ETHYL ESTER

4-HYDROXY-3-METHOXYBENZOIC ACID ETHYL ESTER

3-METHOXY-4-HYDROXYBENZOIC ACID ETHYL ESTER

ETHYL-3-METHOXY-4-HYDROXYBENZOATE

ETHYL 4-HYDROXY-3-METHOXYBENZOATE

ETHYL VANILLATE

Ethyl vanilate

VANILLIC ACID ETHYL ESTER 97+%

2-Iodoanilline

Ethylvanillate,97%

4-HYDROXY-3-METHOXYBENZOIC ACID ETHYL ESTER 98%

ethylvanillate,4-hydroxy-3-methoxybenzoicacidethylester

3-METHOXY-4-HYDROXYBENZOIC ACID ETHYL ESTER 97%

ETHYL 4-HYDROXY-3-METHOXYBENZOAT

ETHYL 3-METHOXY-2-HYDROXYBENZOATE

Benzoicacid,4-hydroxy-3-methoxy-,ethylester

m-Anisic acid, 4-hydroxy-, ethyl ester

Ethyl 4-hydroxy-3-methoxybenzoate ISO 9001：2015 REACH

Ethyl Vanillate， ≥ 98.0%

Ethyl Vanillate, 10 mM in DMSO

617-05-0

617-05-5

HOCH3OC6H3COOC2H5

Inhibitors

FINE Chemical & INTERMEDIATES

Aromatic Esters

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