5-Fluoro-2-nitroanisole
- Product Name
- 5-Fluoro-2-nitroanisole
- CAS No.
- 448-19-1
- Chemical Name
- 5-Fluoro-2-nitroanisole
- Synonyms
- 4-FLUORO-2-METHOXY-1-NITROBENZENE;1-Fluoro-3-Methoxy-4-nitrobenzene;5-Fluoro-2-nitroanis;5-FLUORO-2-NITROANISOL;5-FLUORO-2-NITROANISOLE;Osimertinib Impurity 03;2-Nitro-5-Fluoro Anisole;5-Fluoro-2-nitroanisole99%;5-Fluoro-2-nitroanisole>uoro-2-methoxy-1-nitrobenzene
- CBNumber
- CB0707512
- Molecular Formula
- C7H6FNO3
- Formula Weight
- 171.13
- MOL File
- 448-19-1.mol
5-Fluoro-2-nitroanisole Property
- Melting point:
- 49-51°C
- Boiling point:
- 272°C(lit.)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Amber
- InChI
- InChI=1S/C7H6FNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3
- InChIKey
- WLKUSVNHZXUEFO-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=CC=C(F)C=C1OC
- CAS DataBase Reference
- 448-19-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0703
- Product name
- 5-Fluoro-2-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- F0703
- Product name
- 5-Fluoro-2-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- F593770
- Product name
- 3-Fluoro-6-nitroanisole
- Packaging
- 10g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 033120
- Product name
- 5-Fluoro-2-nitroanisole
- Purity
- 97%
- Packaging
- 25g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- PC0827
- Product name
- 5-Fluoro-2-nitroanisole
- Purity
- 99%
- Packaging
- 25g
- Price
- $41
- Updated
- 2021/12/16
5-Fluoro-2-nitroanisole Chemical Properties,Usage,Production
Uses
3-Fluoro-6-nitroanisole is a reagent used in the synthetic preparation of imidazopyridines as inhibitors of insulin-like growth factor-1 receptor.
Synthesis
446-36-6
77-78-1
448-19-1
In a 5L four-necked flask, 2500 g of N,N-dimethylformamide (DMF), 5-fluoro-2-nitrophenol (500 g, 3.20 mol) and anhydrous potassium carbonate (483 g, 3.50 mol) were added and the mixture was heated up to 60 °C. Dimethyl sulfate (424 g, 3.36 mol) was slowly added dropwise for a controlled period of 2-3 hours. After the dropwise addition, the reaction temperature was raised to 90-100 °C and the reaction was maintained for 5-6 hours. The reaction progress was monitored by gas chromatography (GC) until the content of 5-fluoro-2-nitrophenol was below 0.5%. The reaction mixture was cooled to 50 °C, at which point the monomethyl potassium sulfate salt precipitated. The filtrate was subjected to decompression distillation to recover DMF, resulting in 2-nitro-5-fluoroanisole (515 g, yellow oily liquid). The product was analyzed by GC with 99.5% purity and 94.1% yield.
References
[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2323 - 2332
[2] Patent: CN106083536, 2016, A. Location in patent: Paragraph 0035; 0036
[3] Heterocycles, 1992, vol. 34, # 12, p. 2301 - 2311
[4] Patent: WO2010/71885, 2010, A1. Location in patent: Page/Page column 443
[5] Patent: WO2010/115688, 2010, A1. Location in patent: Page/Page column 146
5-Fluoro-2-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-nitroanisole manufacturers
- Product
- 5-Fluoro-2-nitroanisole 448-19-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- 5-Fluoro-2-nitroanisole 448-19-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 5-Fluoro-2-nitroanisole 448-19-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10