5-Fluoro-2-nitroanisole

Product Name: 5-Fluoro-2-nitroanisole
CAS No.: 448-19-1
Chemical Name: 5-Fluoro-2-nitroanisole
Synonyms: 4-FLUORO-2-METHOXY-1-NITROBENZENE;1-Fluoro-3-Methoxy-4-nitrobenzene;5-Fluoro-2-nitroanis;5-FLUORO-2-NITROANISOL;5-FLUORO-2-NITROANISOLE;Osimertinib Impurity 03;2-Nitro-5-Fluoro Anisole;5-Fluoro-2-nitroanisole99%;5-Fluoro-2-nitroanisole>uoro-2-methoxy-1-nitrobenzene
CBNumber: CB0707512
Molecular Formula: C7H6FNO3
Formula Weight: 171.13
MOL File: 448-19-1.mol

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5-Fluoro-2-nitroanisole Property

Melting point:: 49-51°C
Boiling point:: 272°C(lit.)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Amber
InChI: InChI=1S/C7H6FNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3
InChIKey: WLKUSVNHZXUEFO-UHFFFAOYSA-N
SMILES: C1([N+]([O-])=O)=CC=C(F)C=C1OC
CAS DataBase Reference: 448-19-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-52
HazardClass: IRRITANT
HS Code: 2909309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0703
Product name: 5-Fluoro-2-nitroanisole
Purity: >98.0%(GC)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: F0703
Product name: 5-Fluoro-2-nitroanisole
Purity: >98.0%(GC)
Packaging: 25g
Price: $61
Updated: 2025/07/31

TRC

Product number: F593770
Product name: 3-Fluoro-6-nitroanisole
Packaging: 10g
Price: $155
Updated: 2021/12/16

Oakwood

Product number: 033120
Product name: 5-Fluoro-2-nitroanisole
Purity: 97%
Packaging: 25g
Price: $40
Updated: 2021/12/16

Apolloscientific

Product number: PC0827
Product name: 5-Fluoro-2-nitroanisole
Purity: 99%
Packaging: 25g
Price: $41
Updated: 2021/12/16

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5-Fluoro-2-nitroanisole Chemical Properties,Usage,Production

Uses

3-Fluoro-6-nitroanisole is a reagent used in the synthetic preparation of imidazopyridines as inhibitors of insulin-like growth factor-1 receptor.

Synthesis

446-36-6

77-78-1

448-19-1

In a 5L four-necked flask, 2500 g of N,N-dimethylformamide (DMF), 5-fluoro-2-nitrophenol (500 g, 3.20 mol) and anhydrous potassium carbonate (483 g, 3.50 mol) were added and the mixture was heated up to 60 °C. Dimethyl sulfate (424 g, 3.36 mol) was slowly added dropwise for a controlled period of 2-3 hours. After the dropwise addition, the reaction temperature was raised to 90-100 °C and the reaction was maintained for 5-6 hours. The reaction progress was monitored by gas chromatography (GC) until the content of 5-fluoro-2-nitrophenol was below 0.5%. The reaction mixture was cooled to 50 °C, at which point the monomethyl potassium sulfate salt precipitated. The filtrate was subjected to decompression distillation to recover DMF, resulting in 2-nitro-5-fluoroanisole (515 g, yellow oily liquid). The product was analyzed by GC with 99.5% purity and 94.1% yield.

References

[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2323 - 2332
[2] Patent: CN106083536, 2016, A. Location in patent: Paragraph 0035; 0036
[3] Heterocycles, 1992, vol. 34, # 12, p. 2301 - 2311
[4] Patent: WO2010/71885, 2010, A1. Location in patent: Page/Page column 443
[5] Patent: WO2010/115688, 2010, A1. Location in patent: Page/Page column 146

5-Fluoro-2-nitroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoro-2-nitroanisole Suppliers

Americas 1 Belgium 1 Canada 1 China 303 Europe 1 Germany 1 India 6 Italy 1 Japan 3 United Kingdom 9 United States 32 Global 359

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View Lastest Price from 5-Fluoro-2-nitroanisole manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 5-Fluoro-2-nitroanisole 448-19-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-19

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Fluoro-2-nitroanisole 448-19-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Fluoro-2-nitroanisole 448-19-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

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