RO 20-1724

ChemicalBook > CAS DataBase List > RO 20-1724

Product Name: RO 20-1724
CAS No.: 29925-17-5
Chemical Name: RO 20-1724
Synonyms: RO 20-1724;ro 20-172;R 020-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE;4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE;RO 20-1724, Phosphodiesterase 4 (PDE4) inhibitor;4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE;4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid
CBNumber: CB0710844
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
MOL File: 29925-17-5.mol

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RO 20-1724 Property

Boiling point:: 483.8±25.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: ethanol: 7 mg/mL
form: solid
pka: 14.54±0.40(Predicted)
color: White
biological source: synthetic (organic)
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
CAS DataBase Reference: 29925-17-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B8279
Product name: 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
Purity: solid
Packaging: 100mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: 557502
Product name: Ro-20-1724
Packaging: 100mg
Price: $99.4
Updated: 2024/03/01

Cayman Chemical

Product number: 18272
Product name: Ro 20-1724
Purity: ≥95%
Packaging: 25mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18272
Product name: Ro 20-1724
Purity: ≥95%
Packaging: 50mg
Price: $50
Updated: 2024/03/01

Sigma-Aldrich

Product number: B8279
Product name: 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
Purity: solid
Packaging: 500mg
Price: $512
Updated: 2024/03/01

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RO 20-1724 Chemical Properties,Usage,Production

Description

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable

Uses

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.

Uses

Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.

Definition

ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.

Biological Activity

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Biochem/physiol Actions

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.

storage

Store at RT

References

1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19

RO 20-1724 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 20-1724 Suppliers

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View Lastest Price from RO 20-1724 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: RO 20-1724 29925-17-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

29925-17-5, RO 20-1724Related Search:

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4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE

4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE

4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE

4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE

ro 20-172

RO 20-1724

4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one

Ro-20-1724 - CAS 29925-17-5 - Calbiochem

2-Imidazolidinone, 4-[(3-butoxy-4-methoxyphenyl)methyl]-

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid

R 020-1724

neuroprotective,Ro 201724,Ro 20-174,Ro 20 1724,Ro 20-1724,phosphodiesterase,cognitive,cAMP,antioxidant,inhibit,Inhibitor,Phosphodiesterase (PDE)

RO 20-1724, Phosphodiesterase 4 (PDE4) inhibitor

29925-17-5

Inhibitor of cAMP phosphodiesterase. IC50 33 uM in vascular smooth muscle of the aorta.

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Phosphodiesterase Inhibitors

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide Metabolism

Cyclic Nucleotide related

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase.