RO 20-1724
- Product Name
- RO 20-1724
- CAS No.
- 29925-17-5
- Chemical Name
- RO 20-1724
- Synonyms
- RO 20-1724;ro 20-172;R 020-1724;Ro 20-1724 ，E0346;Ro-20-1724 - CAS 29925-17-5 - Calbiochem;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE;4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE;RO 20-1724, Phosphodiesterase 4 (PDE4) inhibitor;4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE
- CBNumber
- CB0710844
- Molecular Formula
- C15H22N2O3
- Formula Weight
- 278.35
- MOL File
- 29925-17-5.mol
RO 20-1724 Property
- Melting point:
- 125-127°
- Boiling point:
- 483.8±25.0 °C(Predicted)
- Density
- 1.099±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- ethanol: 7 mg/mL
- form
- solid
- pka
- 14.54±0.40(Predicted)
- color
- White
- biological source
- synthetic (organic)
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
- CAS DataBase Reference
- 29925-17-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B8279
- Product name
- 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
- Purity
- solid
- Packaging
- 100mg
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 557502
- Product name
- Ro-20-1724
- Packaging
- 100mg
- Price
- $102
- Updated
- 2025/07/31
- Product number
- 18272
- Product name
- Ro 20-1724
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18272
- Product name
- Ro 20-1724
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- B8279
- Product name
- 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
- Purity
- solid
- Packaging
- 500mg
- Price
- $526
- Updated
- 2025/07/31
RO 20-1724 Chemical Properties,Usage,Production
Description
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Uses
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
Uses
Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.
Definition
ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.
Biological Activity
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
storage
Store at RT
References
[1] S H SODERLING J A B S J Bayuga. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 15: 8991-8996. DOI:10.1073/pnas.95.15.8991
[2] C D NICHOLSON M S R A Challiss. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.[J]. Trends in pharmacological sciences, 1991, 12 1: 19-27. DOI:10.1016/0165-6147(91)90484-a
RO 20-1724 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from RO 20-1724 manufacturers
- Product
- RO 20-1724 29925-17-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11