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EXO1

Product Name
EXO1
CAS No.
75541-83-2
Chemical Name
EXO1
Synonyms
EXO1;EOX 1;NSC 214045;EXOCYTIC INHIBITOR 1;4-FLUORO-BZ-2-ABZ-OME;2-(4-Fluoro-benzoylami;Exo 1 >=98% (HPLC), solid;Exo1 - CAS 75541-83-2 - Calbiochem;Exo1,inhibit,Exo-1,Exo 1,Inhibitor;Methyl 2-(4-fluorobenzamido)benzoate
CBNumber
CB0713355
Molecular Formula
C15H12FNO3
Formula Weight
273.26
MOL File
75541-83-2.mol
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EXO1 Property

storage temp. 
+2C to +8C
solubility 
DMSO: 19 mg/mL, soluble
form 
solid
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E8280
Product name
Exo 1
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$69.3
Updated
2024/03/01
Sigma-Aldrich
Product number
341220
Product name
Exo1
Packaging
25mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
18455
Product name
Exo 1
Purity
≥99%
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
18455
Product name
Exo 1
Purity
≥99%
Packaging
50mg
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
E8280
Product name
Exo 1
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$244
Updated
2024/03/01
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EXO1 Chemical Properties,Usage,Production

Uses

Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus.

Uses

Exo 1 acts as a cell-permeable reverse inhibitor of exocytosis. Potential anti-inflammatory activity.

Uses

Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long?interspersed?nuclear?element-1 (L1) retrotransposition.

Definition

ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides.

Biochem/physiol Actions

Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.

EXO1 Preparation Products And Raw materials

Raw materials

Preparation Products

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EXO1 Suppliers

Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

75541-83-2, EXO1Related Search:


  • 4-FLUORO-BZ-2-ABZ-OME
  • 2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER
  • 2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE
  • 2-(4-Fluoro-benzoylami
  • 2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate
  • EOX 1
  • EXOCYTIC INHIBITOR 1
  • EXO1
  • Exo1, Exocytic Inhibitor 1, 2-(4-Fluoro-benzoylaMino)-benzoic acid Methyl ester
  • EXOCYTIC INHIBITOR 1;NSC 214045;EXO 1;EXO-1
  • NSC 214045
  • Exo1 - CAS 75541-83-2 - Calbiochem
  • Benzoic acid, 2-[(4-fluorobenzoyl)amino]-, methyl ester
  • Exo 1 >=98% (HPLC), solid
  • Exo1,inhibit,Exo-1,Exo 1,Inhibitor
  • Methyl 2-(4-fluorobenzamido)benzoate
  • 75541-83-2
  • C15H12NFO3