Methacryloyl chloride Property

Melting point:

-60°C

Boiling point:

95-96 °C(lit.)

Density 

1.08 g/mL at 20 °C

refractive index 

n20/D 1.442(lit.)

Flash point:

57 °F

storage temp. 

2-8°C

solubility 

Chloroform

form 

Liquid

color 

Clear to slightly colored

Water Solubility 

Miscible with alcohols, ethers and organic solvents. Slightly miscible with water.

Sensitive 

Moisture Sensitive

BRN 

878175

Stability:

Light and Moisture Sensitive

InChIKey

VHRYZQNGTZXDNX-UHFFFAOYSA-N

CAS DataBase Reference

920-46-7(CAS DataBase Reference)

NIST Chemistry Reference

Methacryloyl chloride(920-46-7)

EPA Substance Registry System

Methacryloyl chloride (920-46-7)

Safety

Hazard Codes 

F,T+,Xi

Risk Statements 

11-26/27/28-34-26-22-43-52/53

Safety Statements 

26-28-36/37/39-45-27-16-33-29

RIDADR 

UN 3383 6.1/PG 1

WGK Germany 

3

RTECS 

OZ5791000

F 

21

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

I

HS Code 

29161900

Hazardous Substances Data

920-46-7(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H330Fatal if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Methacryloyl chloride Chemical Properties,Usage,Production

Chemical Properties

clear slightly colored liquid

Uses

Methacryloyl chloride is used in the preparation of polymeric materials. It reacts with L-histidine and forms functional monomer. It is also used to prepare monomer 2-methacrylamido-caprolactam, amide monomers by amidation.

Application

Methacryloyl chloride is used in the manufacture of polymers:
Monomer 2-methacrylamido-caprolactam was prepared by reacting methacryloyl chloride with racemic a-amino-e-caprolactam.
Functional monomer was prepared by reacting methacryloyl chloride and L-histidine.
A series of amide monomers were synthesized by amidation of methacryloyl chloride with amines and grafted onto commercial poly(ether sulfone) (PES) membranes using irradiation from atmospheric pressure plasma (APP).
Reaction of methacryloyl chloride with the hydroxyl groups on the surfaces of HEMA/NVP microspheres was performed, leading to the introduction of polymerisable double bonds onto the surfaces of microspheres.
Star-shaped poly(d,l-lactide) oligomers with 2, 3 and 6 arms were synthesised, end-functionalised with methacryloyl chloride and photo-crosslinked in the presence of ethyl lactate as a non-reactive diluent.

General Description

Methacryloyl chloride is the clear to slightly colored acid chloride of methacrylic acid. It appears as a liquid of density 1.07g/cm3, boiling point 95-96°C, and flash point 55°F. Highly toxic. Supplied in technical grades of varying purity. Monomethyl ether hydroquinone is added as a stabilizer to prevent auto polymerization. Reaction with diisopropyl ether in presence of metal salts is rigorous.

Air & Water Reactions

Highly flammable. Reacts with water to produce gaseous hydrogen chloride (corrosive and toxic).

Reactivity Profile

Methacryloyl chloride is incompatible with strong oxidizing agents, alcohols, bases (including amines). Can polymerize violently; but the polymerization reaction can be inhibited by the addition of phenolthiazine. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Flammable and corrosive liquid.

Purification Methods

Purify the ester by fractional distillation. If it contains the acid (OH bands in the IR) then add redistilled SOCl2 (with cooling) and cuprous chloride (ca to 2%), reflux the mixture gently for 1hour and fractionate it through a 1metre column packed with glass helices. Redistillation then provides the acid chloride in high purity as a colourless liquid. It is necessary to keep the apparatus moisture free (use CaCl2 tubes), Stabilise it with 0.05% of 2,6-di-tert-butyl-4-methylphenol. [Lal & Green J Org Chem 20 1032 1955, Beilstein 2 IV 1537.]