PURPURIN Property

Melting point:

253-256 °C(lit.)

Boiling point:

359.45°C (rough estimate)

Density 

1.659

refractive index 

1.4825 (estimate)

Flash point:

113 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

7.05±0.20(Predicted)

form 

Powder

Colour Index 

58205

color 

Brown-red to brown

Water Solubility 

6.405mg/L(25 ºC)

Merck 

14,7945

BRN 

1887127

LogP

4.600 (est)

CAS DataBase Reference

81-54-9

EPA Substance Registry System

Purpurin (81-54-9)

Safety

Hazard Codes 

Xi,C,F

Risk Statements 

36/37/38-34-11

Safety Statements 

26-36-45-36/37/39-16

WGK Germany 

3

RTECS 

CB8200000

HS Code 

29146990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

PURPURIN Chemical Properties,Usage,Production

Chemical Properties

brown-red to brown powder

Uses

xanthin oxidase inhibitor, irritant

Uses

A xanthine oxidase inhibitor.

Uses

Purpurin is a naturally occurring reddish-yellow pigment found in madder root (R. tinctorum) that has been used both in herbal remedies and as food coloring. It can also by synthetically derived from 9,10-anthraquinone. Purpurin is protective against a number of food-derived heterocyclic amines in bacterial mutagenicity assays through its inhibition of CYP450-dependent N-hydroxylation and reduction of N-hydroxylamines. Purpurine can also inhibit (IC50 = 6.6 μM) spermidine-induced autoactivation of plasma hyaluronan-binding protein, a serine protease that can activate coagulation factor VII and prourokinase.

Uses

Purpurin is an anthraquinone derivative and is well known as a colour pigment derived from madder plants. Purpurin was extensively utilized in herbal remedies, in food colouring and dyes for cotton pr inting. Due to the high antioxidant activity exhibited by anthraquinone compounds, purpurin was determined through studies to possess potential radical scavenging effects. Purprin has also been shown to have inhibitory effects towards serine protease.

Definition

ChEBI: A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4.

Purification Methods

Crystallise purpurin from aqueous EtOH, dry it at 100o. [Beilstein 8 IV 3568.]