Coptisine chloride

Product Name: Coptisine chloride
CAS No.: 6020-18-4
Chemical Name: Coptisine chloride
Synonyms: Q-100696;NSC-119754;Coptisine Hcl;Coptisin chloride;Coptisine choride;COPTISINE CHLORIDE;Coptisin chloride-RM;COPTISINE CHLORIDE(P);Coptisine Hydrochloride;COPTISINECHLORIDE(P)(PLEASECALL)
CBNumber: CB0718668
Molecular Formula: C19H14ClNO4
Formula Weight: 355.77
MOL File: 6020-18-4.mol

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Coptisine chloride Property

Melting point:: >258°C (dec.)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
color: Orange to Dark Orange
Stability:: Hygroscopic
InChI: InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
InChIKey: LUXPUVKJHVUJAV-UHFFFAOYSA-M
SMILES: C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H330Fatal if inhaled

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00314
Product name: Coptisine Chloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $431
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89524
Product name: Coptisine chloride
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $372
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00314
Product name: Coptisine Chloride
Purity: ≥98% (HPLC)
Packaging: 100MG
Price: $1370
Updated: 2023/06/20

TCI Chemical

Product number: C3719
Product name: Coptisine Chloride
Packaging: 25MG
Price: $181
Updated: 2025/07/31

Cayman Chemical

Product number: 28424
Product name: Coptisine (chloride)
Packaging: 10mg
Price: $121
Updated: 2024/03/01

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Coptisine chloride Chemical Properties,Usage,Production

Chemical Properties

Orange Brown Solid

Uses

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD₅₀ value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism^[2].

IC 50

IDO: 6.3 μM (IC₅₀); IDO: 5.8 μM (Ki)

Coptisine chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Coptisine chloride Suppliers

Canada 1 China 224 France 1 Germany 1 India 2 Japan 1 United Kingdom 2 United States 20 Global 252

AdooQ BioScience, LLC

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ALB Technology Limited

Tel: 702-983-3769
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EMMX Biotechnology LLC

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Musechem

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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Aladdin Scientific

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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BOC Sciences

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Quality Phytochemicals LLC

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Cayman Chemical Company

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United States Biological

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MedChemExpress

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Alfa Chemistry

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Ontario Chemicals, Inc

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FortopChem Technology Limited

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Santa Cruz Biotechnology, Inc.

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LKT Laboratories, Inc.

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ChromaDex

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View Lastest Price from Coptisine chloride manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Coptisine chloride 6020-18-4
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-02

Career Henan Chemical Co

Product: Coptisine chloride 6020-18-4
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

6020-18-4, Coptisine chlorideRelated Search:

Ferric chloride Polyvinyl chloride Sulfuryl chloride Choline chloride Aluminum chlorohydrate (-)-STYLOPINE Acetyl chloride Sodium chloride Calcium chloride Ammonium chloride Taxifolin PHELLODENDRINE CHLORIDE SINOMENINE HYDROCHLORIDE Potassium chloride Methylene Chloride COPTISINE 3-HYDROXYPHENETHYLAMINE HYDROCHLORIDE 1-Methylpyridinium chloride

2,3,9,10-BISMETHYLENEDIOXYPROTOBERBERINE

COPTISINE CHLORIDE

COPTISINE CHLORIDE(P)

7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride

Coptisine Hcl

Coptisine Hydrochloride

COPTISINECHLORIDE(P)(PLEASECALL)

6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoliziniuM Chloride

Coptisine chloride 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride

Coptisin chloride

Coptisine chloride, 98%, from Coptis chinensis Franch.

NSC-119754

Q-100696

Coptisine choride

6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium chloride

Coptisin chloride-RM

Coptisine chloride, 10 mM in DMSO

6020-18-4

C19H14ClNO4

C19H14NO4Cl

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

Amines

Heterocycles

Inhibitor

Intermediates & Fine Chemicals

Pharmaceuticals