5-METHYL-1H-PYRROLE-2-CARBALDEHYDE
- Product Name
- 5-METHYL-1H-PYRROLE-2-CARBALDEHYDE
- CAS No.
- 1192-79-6
- Chemical Name
- 5-METHYL-1H-PYRROLE-2-CARBALDEHYDE
- Synonyms
- Nsc81349;5-methyl-2-formylpyrrole;2-formyl-5-methylpyrrole;5-Methylpyrrole-2-carbaldehyde;5-METHYLPYRROLE-2-CARBOXALDEHYDE;Pyrrole-2-carboxaldehyde, 5-methyl;5-METHYL-1H-PYRROLE-2-CARBALDEHYDE;5-methyl-1H-Pyrrole-2-carboxaldehyde;1H-Pyrrole-2-carboxaldehyde, 5-methyl-;5-methyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE)
- CBNumber
- CB0721420
- Molecular Formula
- C6H7NO
- Formula Weight
- 109.13
- MOL File
- 1192-79-6.mol
5-METHYL-1H-PYRROLE-2-CARBALDEHYDE Property
- Melting point:
- 68 °C
- Boiling point:
- 79 °C(Press: 1 Torr)
- Density
- 1.140±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 15.93±0.50(Predicted)
- Appearance
- White to yellow Solid
- LogP
- 0.865 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M330338
- Product name
- 5-Methyl-1H-pyrrole-2-carbaldehyde
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- CS-0038064
- Product name
- 5-Methyl-1H-pyrrole-2-carbaldehyde
- Packaging
- 1g
- Price
- $134
- Updated
- 2021/12/16
- Product number
- 3298AA
- Product name
- 5-Methyl-1H-pyrrole-2-carbaldehyde
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- OR916381
- Product name
- 5-Methyl-1H-pyrrole-2-carbaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0038064
- Product name
- 5-Methyl-1H-pyrrole-2-carbaldehyde
- Packaging
- 5g
- Price
- $412
- Updated
- 2021/12/16
5-METHYL-1H-PYRROLE-2-CARBALDEHYDE Chemical Properties,Usage,Production
Synthesis
636-41-9
68-12-2
1192-79-6
1. Add N,N-dimethylformamide (8.54 g, 117 mmol) and ethylene dichloride (120 mL) to a 250 mL three-necked round-bottomed flask fitted with a magnetic stir bar. 2. Phosphoryl chloride (17.9 g, 117 mmol) was added slowly and dropwise with stirring at 0 °C. The reaction was carried out by stirring. 3. Stir the reaction mixture at room temperature for 15 min. 4. 2-methylpyrrole (10.0 g, 123 mmol) was added slowly and dropwise, keeping the reaction temperature at 0 °C. 5. The reaction mixture was warmed to 80 °C and stirred for 30 min. 6. An aqueous solution (130 mL) of sodium acetate (46 g, 561 mmol) was added to the reaction mixture at room temperature. 7. The reaction mixture was stirred at 80 °C for 20 minutes and then cooled to room temperature. 8. The reaction was quenched with water (100 mL). 9. The reaction mixture was extracted with dichloromethane (3 x 250 mL) and the organic layers were combined. 10. The organic layer was washed with saturated aqueous sodium bicarbonate (150 mL). 11. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. 12. The residue was purified by column chromatography with the eluent ethyl acetate/hexane (1:5 v/v) to afford 5-methylpyrrole-2-carbaldehyde (7.50 g, 56% yield). 13. LCMS (ESI) m/z 110 [M + H].
References
[1] Organic Letters, 2006, vol. 8, # 21, p. 4951 - 4954
[2] Tetrahedron, 1993, vol. 49, # 7, p. 1343 - 1350
[3] Patent: US2016/185786, 2016, A1. Location in patent: Paragraph 0606
[4] Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4980 - 4982
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 16, p. 4054 - 4059
5-METHYL-1H-PYRROLE-2-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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