2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)
- Product Name
- 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)
- CAS No.
- 29681-38-7
- Chemical Name
- 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)
- Synonyms
- NSC 109152;methyl 5-methylpicolinate;5-Methyl-,Methylester(9CI);5-Methylpicolic acid Methyl ester;5-Methylpicolinic acid methyl ester;Methyl 5-methylpyridine-2-carboxylate;Methyl 5-methyl-2-pyridinecarboxylate;Methyl 5-methylpyridine-2-carboxylate 98%;5-Methylpyridine-2-carboxylic acid methyl ester;5-methyl-2-pyridinecarboxylic acid methyl ester
- CBNumber
- CB51282819
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 29681-38-7.mol
2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) Property
- Melting point:
- 54-55℃
- Boiling point:
- 253℃
- Density
- 1.104
- Flash point:
- 107℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 1.98±0.10(Predicted)
- color
- Brown
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M338420
- Product name
- Methyl5-methylpicolinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H58-1-9H
- Product name
- Methyl 5-methylpyridine-2-carboxylate
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
- Product number
- 4H58-1-9H
- Product name
- Methyl 5-methylpyridine-2-carboxylate
- Packaging
- 5G
- Price
- $240
- Updated
- 2021/12/16
- Product number
- W5212
- Product name
- Methyl5-methylpicolinate
- Packaging
- 25g
- Price
- $519
- Updated
- 2021/12/16
- Product number
- 35406
- Product name
- Methyl5-methylpicolinate
- Purity
- 95+%
- Packaging
- 5G
- Price
- $625
- Updated
- 2021/12/16
2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) Chemical Properties,Usage,Production
Synthesis
67-56-1
589-93-5
29681-38-7
Steps for the synthesis of Intermediate 20-6: Methyl 5-methylpyridine-2-carboxylate: Selenium dioxide (4.66 g, 42.0 mmol, CAS 7446-08-4) was added to a solution of 2,5-dimethylpyridine (3.00 g, 28.0 mmol, CAS 589-93-5) dissolved in pyridine (15 mL). The reaction mixture was heated to reflux overnight. After completion of the reaction, it was cooled to room temperature, the solid precipitate was removed by filtration and washed sequentially with water and pyridine (5 mL each, 2 times). The filtrate was evaporated and the crude product obtained was redissolved in methanol (100 mL). Sulfuric acid (1.34 mL, 25.0 mmol) was added to this solution and the reaction mixture was then heated to reflux for 5 hours. At the end of the reaction, it was cooled to room temperature and the reaction mixture was alkalized with 20% NaOH aqueous solution. Methanol was removed by evaporation and diluted by adding water (50 mL). The mixture was extracted with diethyl ether (DEE, 3 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), and the solvent was evaporated to give the title compound methyl 5-methylpyridine-2-carboxylate (2.11 g, 50% yield) as a light brown oil.1H NMR (400 MHz, CDCl3) δ 2.40 (s, 3H), 3.97 (s, 3H), 7.61 (d, 1H), 8.01 (d , 1H), 8.54 (s, 1H).
References
[1] Patent: WO2009/81195, 2009, A1. Location in patent: Page/Page column 84
[2] Patent: WO2012/80221, 2012, A1. Location in patent: Page/Page column 83-84
[3] Patent: US2013/274260, 2013, A1. Location in patent: Paragraph 0620-0621
[4] Patent: WO2009/10794, 2009, A1. Location in patent: Page/Page column 61-62
[5] Tetrahedron Asymmetry, 2001, vol. 12, # 17, p. 2385 - 2387
2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) manufacturers
- Product
- Methyl 5-methylpicolinate 29681-38-7
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-13
- Product
- 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) 29681-38-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30