ethyl 5-methylpyridine-2-carboxylate
- Product Name
- ethyl 5-methylpyridine-2-carboxylate
- CAS No.
- 55876-82-9
- Chemical Name
- ethyl 5-methylpyridine-2-carboxylate
- Synonyms
- Ethyl 5-Methylpicolinate;ethyl 5-methylpyridine-2-carboxylate;5-methyl-2-Pyridinecarboxylic acid ethyl ester;5-METHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;2-Pyridinecarboxylic acid, 5-Methyl-, ethyl ester
- CBNumber
- CB81561081
- Molecular Formula
- C9H11NO2
- Formula Weight
- 165.19
- MOL File
- 55876-82-9.mol
ethyl 5-methylpyridine-2-carboxylate Property
- Boiling point:
- 123-124 °C(Press: 15 Torr)
- Density
- 1.077±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.12±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E937055
- Product name
- Ethyl5-Methylpicolinate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 071343
- Product name
- Ethyl 5-methylpyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- 071343
- Product name
- Ethyl 5-methylpyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $186
- Updated
- 2021/12/16
- Product number
- J50958
- Product name
- Ethyl5-methylpicolinate
- Packaging
- 25g
- Price
- $370
- Updated
- 2021/12/16
- Product number
- 071343
- Product name
- Ethyl 5-methylpyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $375
- Updated
- 2021/12/16
ethyl 5-methylpyridine-2-carboxylate Chemical Properties,Usage,Production
Synthesis
1620-77-5
64-17-5
55876-82-9
General procedure for the synthesis of ethyl 5-methylpyridine-2-carboxylate from 2-cyano-5-methylpyridine and ethanol: To a solution of 2-cyano-5-methylpyridine (5 g, 42.3 mmol, 1.00 equiv) in ethanol (40 mL) was added concentrated sulfuric acid (10 mL, 4.00 equiv). The resulting solution was stirred at 80 °C for 48 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature (25 °C). Subsequently, the mixture was concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted with water (100 mL) and the pH was adjusted with potassium carbonate to 8-9. The aqueous phase was extracted with ethyl acetate (3 x 100 mL) and the organic phases were combined. The organic phase was washed sequentially with water (3 × 50 mL) and saturated saline (3 × 50 mL). Finally, the organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford ethyl 5-methylpyridine-2-carboxylate (3 g, 43% yield) as a light yellow oil.LC-MS analysis showed the molecular ion peak of the target product m/z = 166 [M + H]+ .
References
[1] Organic and Biomolecular Chemistry, 2011, vol. 9, # 8, p. 3026 - 3032
[2] Patent: US2018/79742, 2018, A1. Location in patent: Paragraph 0322; 0323
ethyl 5-methylpyridine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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