1-Methyl-3-nitro-1-nitrosoguanidine Property

Melting point:

118°C (dec.)

Boiling point:

267.16°C (rough estimate)

Density 

1.7979 (rough estimate)

refractive index 

1.6410 (estimate)

storage temp. 

0-6°C

solubility 

almost transparency in hot Methanol

form 

powder to crystal

pka

3.09±0.50(Predicted)

color 

Light yellow to Brown

Water Solubility 

Reacts violently

Merck 

14,6103

Stability:

Unstable. Reacts violently with water. May detonate under impact. Heat, light and moisture sensitive. May explode if stored in sealed ampules. Highly flammable. Incompatible with aqueous solutions, acids, bases, oxidizing agents, reducing agents. Alkaline hydrolysis releases toxic and explosive gases.

InChIKey

VZUNGTLZRAYYDE-UHFFFAOYSA-N

CAS DataBase Reference

70-25-7(CAS DataBase Reference)

NIST Chemistry Reference

Guanidine, n-methyl-n'-nitro-n-nitroso-(70-25-7)

IARC

2A (Vol. 4, Sup 7) 1987

EPA Substance Registry System

N-Methyl-N'-nitro-N-nitrosoguanidine (70-25-7)

Safety

Hazard Codes 

T;N,N,T

Risk Statements 

45-20-36/38-51/53

Safety Statements 

53-45-61

RIDADR 

2926

RTECS 

MF4200000

HS Code 

2925.29.9000

HazardClass 

4.1

PackingGroup 

II

Hazardous Substances Data

70-25-7(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 90mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H350May cause cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

1-Methyl-3-nitro-1-nitrosoguanidine Chemical Properties,Usage,Production

Chemical Properties

yellow to pink crystals

Uses

A DNA-damaging agent, used as a positive control in SHE cell transformation assays.

Uses

Experimentally as carcinogen and mutagen. Formerly in preparation of diazomethane.

Definition

ChEBI: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position

Production Methods

MNNG is one of the first chemical mutagens and is a stabilized form of methylnitrosoguanidine, which has not been isolated. It does not occur in nature, and human exposure to it is limited to laboratories.

General Description

A yellow powder. Melting point 244°F. Decomposes above 212°F. A suspected carcinogen. Extremely hazardous as a mutagen. Avoid skin contact and inhalation of of vapors. Usually stored frozen (below 32°F) in polyethylene bottles that are tightly closed and contained in a metal can. May decomposed during prolonged storage and develop sufficient pressure in a closed container to explode. Keep away from heat, sparks, and open flame.

Air & Water Reactions

Highly flammable. Reacts violently with water .

Reactivity Profile

1-Methyl-3-nitro-1-nitrosoguanidine will detonate under high impact. 1-Methyl-3-nitro-1-nitrosoguanidine is sensitive to heat. A sample has exploded when melted in a sealed capillary tube. Incompatible with acids, bases, oxidizing agents and reducing agents. Reacts with bases to release highly toxic, irritating and explosive gases. Reacts slowly with acids to release nitrous acid. Reacts with various nucleophiles, especially amines and thiols. Reacts with aqueous potassium hydroxide to form a highly reactive compound. The crude product from aqueous nitrosation is pyrophoric but recrystallized material is stable .

Health Hazard

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. Human mutation data reported. An explosive sensitive to heat or impact. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits very toxic fumes of NOx.

Carcinogenicity

N-Methyl-N-nitro-N-nitrosoguanidine (MNNG) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.