ChemicalBook > CAS DataBase List > Baicalein

Baicalein

Product Name
Baicalein
CAS No.
491-67-8
Chemical Name
Baicalein
Synonyms
5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one;Baicelein;5,6,7-Trihydroxyflavone,97%;BaicaL;Noroxylin;Baicalein;Baicaleine;Baicalein-RM;Baicalein 98%;Baicalein std.
CBNumber
CB0738154
Molecular Formula
C15H10O5
Formula Weight
270.24
MOL File
491-67-8.mol
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Baicalein Property

Melting point:
256-271 °C (lit.)
Boiling point:
373.35°C (rough estimate)
Density 
1.3280 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Yellow solid
pka
6.31±0.40(Predicted)
color 
Yellow or yellow-green
Merck 
14,942
BRN 
272683
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey
FXNFHKRTJBSTCS-UHFFFAOYSA-N
LogP
3.310 (est)
CAS DataBase Reference
491-67-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DJ3100898
Hazard Note 
Irritant
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
465119
Product name
Baicalein
Purity
98%
Packaging
100mg
Price
$49.9
Updated
2024/03/01
Sigma-Aldrich
Product number
196322
Product name
Baicalein
Packaging
10mg
Price
$172
Updated
2024/03/01
TCI Chemical
Product number
T2721
Product name
Baicalein
Purity
>98.0%(T)
Packaging
1g
Price
$188
Updated
2024/03/01
TCI Chemical
Product number
T2721
Product name
Baicalein
Purity
>98.0%(T)
Packaging
5g
Price
$469
Updated
2024/03/01
Alfa Aesar
Product number
L14185
Product name
5,6,7-Trihydroxyflavone, 97%
Packaging
100mg
Price
$38.65
Updated
2024/03/01
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Baicalein Chemical Properties,Usage,Production

Description

Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis.1?Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64 μM for 12-LO and 1.6 μM for 15-LO).2 Baicalein displays anti-inflammatory activity and inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (IC50=36 μM).3

Chemical Properties

Yellow Crystalline Solid

Uses

Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 μM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM). Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 μM. In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 μg/ml.

Uses

antiviral (HIV)

Uses

An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs.

Uses

inhibitor of lipoxidase and leukotriene biosynthesis

Uses

An inhibitor of Ca2+ uptake, 5-LO, and 12-LO

Definition

ChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.

General Description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Biological Activity

Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo .

Biochem/physiol Actions

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

References

1) Lee?et al. (2005),?Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells; Anticancer Res.,?25?959 2) Deschamps?et al. (2006),?Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases; Bioorg. Med. Chem.,?14?4295 3) Tarrago?et al. (2008),?Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor; Bioorg. Med. Chem.,?16?7516

Baicalein Preparation Products And Raw materials

Raw materials

Preparation Products

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Baicalein Suppliers

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View Lastest Price from Baicalein manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Baicalein 491-67-8
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Baicalein 491-67-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%HPLC
Supply Ability
1000 KG
Release date
2021-06-04
Wuhan Haorong Biotechnology Co.,Ltd
Product
Baicalein 491-67-8
Price
US $0.00-0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
200000
Release date
2023-08-15

491-67-8, BaicaleinRelated Search:

Riboflavin Theaflavin Isoflavone Curcumin Scutellarin 7-HYDROXYFLAVONE Emodin Chrysin FLAVONE ISOFLAVONES 5,6,7-TRIMETHOXYFLAVONE 6-METHOXYLUTEOLIN Wogonoside Wogonin SCUTELLAREIN Baicalin EUPATORIN-5-METHYL ETHER 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE

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  • C15H10O5H2O
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  • The flavonoid component of Nepalese and Sino-Japanese crude drugs
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