Mangostin

Product Name: Mangostin
CAS No.: 6147-11-1
Chemical Name: Mangostin
Synonyms: mangostin;NSC 27593;NSC 30552;NSC 139154;MANGOSTINE;Mangosteen;α-Mangosten;a-Mangosten;a-Mangostin;α-mangostin
CBNumber: CB0739500
Molecular Formula: C24H26O6
Formula Weight: 410.46
MOL File: 6147-11-1.mol

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Mangostin Property

Melting point:: 180-182°C
Boiling point:: 640.1±55.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: methanol: soluble1mg/mL, clear, very light yellow
pka: 7.22±0.20(Predicted)
form: powder
color: faint yellow to yellow
λmax: 346nm(MeOH)(lit.)
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI: InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey: GNRIZKKCNOBBMO-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
CAS DataBase Reference: 6147-11-1(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 1
RTECS: ZD6122420
HS Code: 29329990
Hazardous Substances Data: 6147-11-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M3824
Product name: α-Mangostin
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $248
Updated: 2024/03/01

Sigma-Aldrich

Product number: M3824
Product name: α-Mangostin
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $785
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89247
Product name: Mangostin
Purity: phyproof? Reference Substance
Packaging: 25MG
Price: $317
Updated: 2023/01/07

Sigma-Aldrich

Product number: 07589
Product name: α-Mangostin
Purity: analytical standard
Packaging: 25MG
Price: $696
Updated: 2022/05/15

TCI Chemical

Product number: M2793
Product name: α-Mangostin
Purity: >97.0%(HPLC)
Packaging: 10mg
Price: $86
Updated: 2024/03/01

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Mangostin Chemical Properties,Usage,Production

Description

α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-β production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5

Chemical Properties

Yellow Crystalline Solid

Uses

It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent

Uses

antifungal, antilarval

Uses

α-Mangostin has been used:

to study its protective effect against oxidative stress mediated-retinal cell death
to study its role as an antigenotoxic agent in DNA protection against oxidative damage
to understand its anti-bacterial activity against Staphylococcus epidermidis?RP62A

Definition

ChEBI: Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.

storage

Store at -20°C

References

1) Mohan et al. (2018), An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach; Food Funct., 9 3860 2) Zhang et al. (2018), Identification of α-Mangostin as an Agonist of Human STING; Chem. Med. Chem.,?13 2057 3) Lee et al. (2018), Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-induced Damage; J. Mol. Sci., 19 E1484 4) Chen et al. (2017), Alpha-Mangostin Suppresses the Metastasis of Human renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity; Cell Physiol. Biochem., 44 1460 5) Xia and Sun (2018), Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment; Clin. Exp. Dermatol., 43 149

Mangostin Preparation Products And Raw materials

Raw materials

Preparation Products

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Mangostin Suppliers

Americas 1 Canada 1 CHINA 254 Europe 1 Germany 2 India 6 Japan 1 United Kingdom 5 United States 23 Global 294

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
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Aladdin Scientific

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ProdList: 57505
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ApexBio Technology

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SynFine Research

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Wilshire Chemical Company Inc.

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Focus Biomolecules

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Cayman Chemical Company

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United States Biological

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Glentham Life Sciences Ltd

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TCI America

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MedChemExpress

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Combi-Blocks Inc.

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Riedel-de Haen AG

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Frontier Scientific, Inc.

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Matrix Scientific

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FortopChem Technology Limited

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Medical Isotopes

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INDOFINE Chemical Company, Inc.

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3B Scientific Corporation

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ChromaDex

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Research Plus, Inc.

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View Lastest Price from Mangostin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Mangosteen Peel Extract / Alpha Mangostin 6147-11-1
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Mangostin; α-Mangostin 6147-11-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 1%-98% HPLC
Supply Ability: 1000KG
Release date: 2022-12-08

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Fructus monordicae extract
Price: US $0.00/KG
Min. Order: 1KG
Purity: 10%-50% HPLC
Supply Ability: 1000KG
Release date: 2022-10-08

6147-11-1, MangostinRelated Search:

Methyl acrylate 4-Methoxyphenylacetic acid METHYL THIOPHENE-2-CARBOXYLATE 4-Methoxybenzylchloride (Trifluoromethoxy)benzene p-Anisaldehyde Thiophanate-methyl 3-(METHOXYMETHOXY)BENZALDEHYDE Methylparaben Grape Seed Extract Bensulfuron methyl p-Anisidine 4-Methoxyphenylacetone Anisole Kresoxim-methyl Ginkgo biloba extract Methyl Parathion-methyl

α-Mangostin, 98%, from Garcinia mangostana

α-Mangostin (a-Mangostin、ALPHA-Mangostin)

α-Mangostin, froM Garcinia Mangostana

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on

Alpha-Mangostin α-Mangostin

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one

1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE

Mangosteen

mangostin

MANGOSTINE

NSC 139154

NSC 27593

NSC 30552

α-Mangosten

a-Mangosten

a-Mangostin

Momordica Fruit P.E.

Fructus Monordicae extract

1,3,6-Trihydroxy-2,8-diprenyl-7-methoxy-9H-xanthene-9-one

7-Methoxy-1,3,6-trihydroxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthene-9-one

Xango, Mangostan, Queen of fruits

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3,3-dimethylallyl)xanthone

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

1,3,6-Trihydroxy-7-Methoxy-2,8-bis(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one

1,3,6-Trihydroxy-7-Methoxy-2,8-bis(3-Methyl-2-butenyl)-9H-xanten-9-one

9H-Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-

9H-Xanthen-9-one,1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-

α-mangostin

Low poly fructose

Shanzhu fruit powder

GARCININA MANGOSTEEN POWDER

Mangostin USP/EP/BP

1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one

TIANFU-CHEM Mangostin

α- Reverse twister

α- Inverted twister element

Mangostin Α, Β, Γ

Alpha-Mangostin α-Mangostin

α-Mangostin (a-Mangostin、ALPHA-Mangostin)

Mangosteen Peel Extract / Alpha Mangostin

MANGOSTIN ALPHA-(RG) 10mg

MANGOSTIN ALPHA-(RG) 1g

MANGOSTIN ALPHA-(RG) 50mg

Mangostin-RM

6147-11-1

931-37-7

11/1/6147

reagent

standard substance

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Xanthones

Intermediates & Fine Chemicals

Pharmaceuticals

chemical reagent

pharmaceutical intermediate

phytochemical