ChemicalBook > CAS DataBase List > 2-Bromo-5-fluoroanisole

2-Bromo-5-fluoroanisole

Product Name: 2-Bromo-5-fluoroanisole
CAS No.: 450-88-4
Chemical Name: 2-Bromo-5-fluoroanisole
Synonyms: BUTTPARK 87\07-62;2-BROMO-5-FLUOROANISOLE;2-Bromo-5-fluoroanisole >2-Bromo-5-fluoroanisole98+%;2-bromo-5-fluorobenzane ether;2-methoxy-4-fluorobromobenzene;1-Bromo-4-fluoro-2-methoxybenzene;2-BroMo-5-fluoroanisole, 95.0%(GC);Benzene, 1-bromo-4-fluoro-2-methoxy-;2-Bromo-5-fluoroanisole ISO 9001：2015 REACH
CBNumber: CB0745262
Molecular Formula: C7H6BrFO
Formula Weight: 205.02
MOL File: 450-88-4.mol

Less

2-Bromo-5-fluoroanisole Property

Boiling point:: 143-145 °C
Density: 1.5983
refractive index: 1.542
Flash point:: 90 °C
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
color: Colorless to Light yellow
InChIKey: KGYXKRGMSUHYCY-UHFFFAOYSA-N
CAS DataBase Reference: 450-88-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-36-22
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Harmful
HS Code: 29093090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 682543
Product name: 2-Bromo-5-fluoroanisole
Purity: 99%
Packaging: 5g
Price: $179
Updated: 2022/05/15

TCI Chemical

Product number: B3875
Product name: 2-Bromo-5-fluoroanisole
Purity: >95.0%(GC)
Packaging: 5g
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: B3875
Product name: 2-Bromo-5-fluoroanisole
Purity: >95.0%(GC)
Packaging: 25g
Price: $442
Updated: 2025/07/31

TRC

Product number: B691890
Product name: 2-Bromo-5-fluoroanisole
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105377
Product name: 1-Bromo-4-fluoro-2-methoxybenzene
Packaging: 25g
Price: $110
Updated: 2021/12/16

Less

2-Bromo-5-fluoroanisole Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid to pale yellow liquid

Uses

2-Bromo-5-fluoroanisole is a halogenated anisole compound, the chemical reactivity of which is mainly concentrated on the bromine atom on its benzene ring. It can be used as an organic synthesis intermediate and a synthetic raw material for drug molecules. For example, literature reports that the substance can be used for the preparation of the drug molecule anacetrapib.

Synthesis

77-78-1

147460-41-1

450-88-4

a) A suspension of 2-bromo-5-fluorophenol (20.0 g, 104.7 mmol) and potassium carbonate (21.71 g, 157.1 mmol) was formed in acetone (200 mL). To this suspension dimethyl sulfate (10.90 mL, 115.2 mmol) was slowly added. The reaction mixture was stirred at 60 °C for 2 h. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in a mixture of ether (200 mL) and water (100 mL) to separate the organic phase. The organic phase was washed sequentially with 2N aqueous hydrochloric acid (50 mL) and saturated sodium bicarbonate solution (50 mL), and then dried with anhydrous magnesium sulfate. The dried organic phase was evaporated from the solvent under reduced pressure to give the light yellow oily product 2-bromo-5-fluoroanisole (21.46 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 7.45 (1H, dd, Ar-H), 6.70-6.55 (2H, m, Ar-H), 3.90 (3H, s, OCH3).

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 29
[2] Patent: WO2004/43903, 2004, A1. Location in patent: Page 30
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 28

2-Bromo-5-fluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Bromo-5-fluoroanisole Suppliers

Americas 1 Belgium 1 China 189 Europe 1 France 1 Germany 5 India 6 Italy 1 Japan 1 The Netherlands 1 United Kingdom 15 United States 35 Global 257

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3763
Advantage: 58

Tianjin Jinyuda Chemical Co., Ltd.

Tel: 022-58013646 13011382049
Fax: 022-23854368
Email: sales@jinyudachem.com
Country: China
ProdList: 1930
Advantage: 55

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Jalor-Chem co.,LTD

Tel: 0510-0510-86396359 13382276200
Email: sales@jalor-chem.com
Country: China
ProdList: 996
Advantage: 56

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Country: China
ProdList: 2930
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2786
Advantage: 52

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Shanghai Jovan Biochemical Technology Co. Ltd.

Tel: +86-021-61654350
Fax: +86-021-61654350
Email: 1245958370@qq.com
Country: China
ProdList: 2982
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Nanjing Endesa Bio-tech Co., Ltd.

Tel: 025-58862853 18915922038
Fax: +86-025-58862853
Email: sales@endesachem.com
Country: China
ProdList: 591
Advantage: 58

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Chengdu Research Accelerators Technology Co., Ltd.

Tel: 028-64353063
Fax: 028-64353063 QQ:784253935
Email: reacchemical@163.com
Country: China
ProdList: 5253
Advantage: 58

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3909
Advantage: 58

Less

View Lastest Price from 2-Bromo-5-fluoroanisole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-5-fluoroanisole 450-88-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Honest Joy Holdings Limited

Product: 2-Bromo-5-fluoroanisole 450-88-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-01-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Bromo-5-fluoroanisole 450-88-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

450-88-4, 2-Bromo-5-fluoroanisoleRelated Search:

4-Fluorobenzaldehyde 2-Bromoanisole Anisole 3-Fluoroanisole Florfenicol 4-Fluoroanisole 1,2-Difluorobenzene Transfluthrin 4-Bromofluorobenzene Fluorine 3-BROMO-4-FLUOROANISOLE 4-BROMO-3-FLUOROANISOLE,98%,4-BROMO-3-FLUOROANISOLE Bromine N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE 2-Bromo-4,5-difluoroanisole 3-Bromo-6-fluoro-2-methoxyphenylboronic acid 4-Bromo-3-fluoroanisole 3-BROMO-5-FLUOROANISOLE,5-BROMO-3-FLUOROANISOLE

2-BroMo-5-fluoroanisole, 95.0%(GC)

1-Bromo-4-fluoro-2-methoxybenzene, 2-Bromo-5-fluorophenyl methyl ether

BUTTPARK 87\07-62

2-BROMO-5-FLUOROANISOLE

1-Bromo-4-fluoro-2-methoxybenzene

2-Bromo-5-fluoroanisole98+%

2-Bromo-5-fluoroanisole &gt

Benzene, 1-bromo-4-fluoro-2-methoxy-

2-Bromo-5-fluoroanisole ISO 9001：2015 REACH

2-methoxy-4-fluorobromobenzene

2-bromo-5-fluorobenzane ether

450-88-4

Anisole