4-Bromo-3-fluoroanisole

Product Name: 4-Bromo-3-fluoroanisole
CAS No.: 458-50-4
Chemical Name: 4-Bromo-3-fluoroanisole
Synonyms: 1-Bromo-2-fluoro-4-methoxybenzene;4-Bromo-3-fluoroanisole;4- broMo-3- fluoroether;4-BROMO-3-FLUOROANISOLE;4-Bromo-3-fluoroanisole>4-BROMO-3-FLUOROANISOLE,98%;4-Bromo-3-fluoroanisole 98%;4-BROMO-3-FLUOROANISOLE 99+%;Benzene, 1-bromo-2-fluoro-4-methoxy-;4-Bromo-3-fluoroanisole ISO 9001：2015 REACH
CBNumber: CB8168650
Molecular Formula: C7H6BrFO
Formula Weight: 205.02
MOL File: 458-50-4.mol

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4-Bromo-3-fluoroanisole Property

Melting point:: 217-219°C
Boiling point:: 195.4±20.0 °C(Predicted)
Density: 1.60
refractive index: 1.5410-1.5450
Flash point:: 85°(185°F)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow to Light orange
InChI: InChI=1S/C7H6BrFO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3
InChIKey: XANVIFOBBVAKCY-UHFFFAOYSA-N
SMILES: C1(Br)=CC=C(OC)C=C1F
CAS DataBase Reference: 458-50-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-26-37-60
RIDADR: 1993
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3743
Product name: 4-Bromo-3-fluoroanisole
Purity: >98.0%(GC)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: B3743
Product name: 4-Bromo-3-fluoroanisole
Purity: >98.0%(GC)
Packaging: 25g
Price: $234
Updated: 2025/07/31

TRC

Product number: B684390
Product name: 4-Bromo-3-fluoroanisole
Packaging: 2.5mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2607-B-15
Product name: 4-Bromo-3-fluoroanisole
Purity: 98%
Packaging: 25g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19119
Product name: 4-Bromo-3-fluoroanisole
Packaging: 25g
Price: $100
Updated: 2021/12/16

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4-Bromo-3-fluoroanisole Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

4-Bromo-3-fluoroanisole is a halo-aryl compound used in the preparation of orally available mGlu1 receptor enhancers.

Synthesis

121219-03-2

74-88-4

458-50-4

Step 1: Synthesis of 1-bromo-2-fluoro-4-methoxybenzene To a 250 mL round bottom flask was added 4-bromo-3-fluorophenol (5.0 g, 26.18 mmol, 1.00 equiv) and tetrahydrofuran (50 mL). Subsequently, potassium hydroxide (2.94 g, 52.40 mmol, 2.00 equiv) was added in batches. Under stirring, iodomethane (5.6 g, 39.45 mmol, 1.51 eq.) was added dropwise. The reaction mixture was stirred at 30°C for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio petroleum ether:ethyl acetate = 1:4). Upon completion of the reaction, the reaction was quenched by the addition of 30 mL of water. The reaction mixture was extracted with ethyl acetate (3 x 30 mL), the organic layers were combined and dried with anhydrous sodium sulfate. Subsequently, the organic layer was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using petroleum ether as eluent to give 5.2 g (97% yield) of 1-bromo-2-fluoro-4-methoxybenzene as a yellow oil.

References

[1] Patent: US2014/275179, 2014, A1. Location in patent: Paragraph 0738; 0739
[2] Patent: US9067898, 2015, B1. Location in patent: Page/Page column 57; 58
[3] Patent: WO2015/134039, 2015, A1. Location in patent: Page/Page column 69-70
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 12, p. 3909 - 3913
[5] Angew. Chem., 2016, p. 3977 - 3981,5

4-Bromo-3-fluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-fluoroanisole Suppliers

Americas 1 Belgium 2 Canada 2 China 200 Europe 1 France 1 Germany 8 India 7 Italy 1 Japan 2 Slovakia 1 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 31 Global 270

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View Lastest Price from 4-Bromo-3-fluoroanisole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BROMO-3-FLUOROANISOLE 458-50-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BROMO-3-FLUOROANISOLE 458-50-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BROMO-3-FLUOROANISOLE 458-50-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

458-50-4, 4-Bromo-3-fluoroanisoleRelated Search:

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4-Bromo-3-fluoroanisole ISO 9001：2015 REACH

458-50-4

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