4-Bromo-3-fluoroanisole
- Product Name
- 4-Bromo-3-fluoroanisole
- CAS No.
- 458-50-4
- Chemical Name
- 4-Bromo-3-fluoroanisole
- Synonyms
- 1-Bromo-2-fluoro-4-methoxybenzene;4-Bromo-3-fluoroanisole;4- broMo-3- fluoroether;4-BROMO-3-FLUOROANISOLE;4-Bromo-3-fluoroanisole>4-BROMO-3-FLUOROANISOLE,98%;4-Bromo-3-fluoroanisole 98%;4-BROMO-3-FLUOROANISOLE 99+%;Benzene, 1-bromo-2-fluoro-4-methoxy-;4-Bromo-3-fluoroanisole ISO 9001：2015 REACH
- CBNumber
- CB8168650
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 458-50-4.mol
4-Bromo-3-fluoroanisole Property
- Melting point:
- 217-219°C
- Boiling point:
- 195.4±20.0 °C(Predicted)
- Density
- 1.60
- refractive index
- 1.5410-1.5450
- Flash point:
- 85°(185°F)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C7H6BrFO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3
- InChIKey
- XANVIFOBBVAKCY-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(OC)C=C1F
- CAS DataBase Reference
- 458-50-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 23-26-37-60
- RIDADR
- 1993
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B3743
- Product name
- 4-Bromo-3-fluoroanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- B3743
- Product name
- 4-Bromo-3-fluoroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $234
- Updated
- 2025/07/31
- Product number
- B684390
- Product name
- 4-Bromo-3-fluoroanisole
- Packaging
- 2.5mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 2607-B-15
- Product name
- 4-Bromo-3-fluoroanisole
- Purity
- 98%
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB19119
- Product name
- 4-Bromo-3-fluoroanisole
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
4-Bromo-3-fluoroanisole Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to light yellow liquid
Uses
4-Bromo-3-fluoroanisole is a halo-aryl compound used in the preparation of orally available mGlu1 receptor enhancers.
Synthesis
121219-03-2
74-88-4
458-50-4
Step 1: Synthesis of 1-bromo-2-fluoro-4-methoxybenzene To a 250 mL round bottom flask was added 4-bromo-3-fluorophenol (5.0 g, 26.18 mmol, 1.00 equiv) and tetrahydrofuran (50 mL). Subsequently, potassium hydroxide (2.94 g, 52.40 mmol, 2.00 equiv) was added in batches. Under stirring, iodomethane (5.6 g, 39.45 mmol, 1.51 eq.) was added dropwise. The reaction mixture was stirred at 30°C for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio petroleum ether:ethyl acetate = 1:4). Upon completion of the reaction, the reaction was quenched by the addition of 30 mL of water. The reaction mixture was extracted with ethyl acetate (3 x 30 mL), the organic layers were combined and dried with anhydrous sodium sulfate. Subsequently, the organic layer was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using petroleum ether as eluent to give 5.2 g (97% yield) of 1-bromo-2-fluoro-4-methoxybenzene as a yellow oil.
References
[1] Patent: US2014/275179, 2014, A1. Location in patent: Paragraph 0738; 0739
[2] Patent: US9067898, 2015, B1. Location in patent: Page/Page column 57; 58
[3] Patent: WO2015/134039, 2015, A1. Location in patent: Page/Page column 69-70
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 12, p. 3909 - 3913
[5] Angew. Chem., 2016, p. 3977 - 3981,5
4-Bromo-3-fluoroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-3-fluoroanisole manufacturers
- Product
- 4-BROMO-3-FLUOROANISOLE 458-50-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-BROMO-3-FLUOROANISOLE 458-50-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 4-BROMO-3-FLUOROANISOLE 458-50-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27