5-Bromo-3-chloro-2-fluoropyridine
- Product Name
- 5-Bromo-3-chloro-2-fluoropyridine
- CAS No.
- 38185-56-7
- Chemical Name
- 5-Bromo-3-chloro-2-fluoropyridine
- Synonyms
- 5-Bromo-3-Chloro-6-Fluoropyridine;5-Bromo-3-chloro-2-fluoropyridine;3-BROMO-5-CHLORO-6-FLUOROPYRIDINE;2-Fluoro-3-Chloro-5-Bromopyridine;Pyridine, 5-bromo-3-chloro-2-fluoro-;5-Bromo-3-chloro-2-fluoropyridine 98%;5-Bromo-3-chloro-2-fluoropyridine,95%;2-Fluoro-3-Chloro-5-Bromopyridine ISO 9001：2015 REACH
- CBNumber
- CB11033325
- Molecular Formula
- C5H2BrClFN
- Formula Weight
- 210.43
- MOL File
- 38185-56-7.mol
5-Bromo-3-chloro-2-fluoropyridine Property
- Melting point:
- 60℃
- Boiling point:
- 206.3±35.0 °C(Predicted)
- Density
- 1.829±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- Solid
- pka
- -5.07±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 38185-56-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B683218
- Product name
- 5-Bromo-3-chloro-2-fluoropyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B683218
- Product name
- 5-Bromo-3-chloro-2-fluoropyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- BP-11820
- Product name
- 5-bromo-3-chloro-2-fluoropyridine
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- FB105468
- Product name
- 5-Bromo-3-chloro-2-fluoropyridine
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- PC400730
- Product name
- 5-Bromo-3-chloro-2-fluoropyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $160
- Updated
- 2021/12/16
5-Bromo-3-chloro-2-fluoropyridine Chemical Properties,Usage,Production
Uses
5-Bromo-3-chloro-2-fluoropyridine is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
38185-55-6
38185-56-7
2) The reaction system was cooled in an ice bath, followed by the slow addition of sodium nitrite (4.8 g, 70 mmol) to a solution consisting of the above amine product (12.6 g, 61 mmol) dissolved in hydrogen fluoride/pyridine (70% HF, 91 ml). The reaction mixture was stirred continuously for 30 min at room temperature. After completion of the reaction, ice was added to the reaction solution and neutralized with sodium carbonate solution. Subsequently, the organic layer was separated by extraction with ether. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure to remove the solvent. The crude product obtained was further purified by silica gel column chromatography (eluent ratio hexane:ethyl acetate=80:20) to afford the target compound 5-bromo-3-chloro-2-fluoropyridine (11.1 g, 87% yield) as a white solid.
References
[1] Patent: EP2221301, 2010, A1. Location in patent: Page/Page column 46
[2] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 143-144
5-Bromo-3-chloro-2-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-3-chloro-2-fluoropyridine manufacturers
- Product
- 5-Bromo-3-chloro-2-fluoropyridine 38185-56-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 2-Fluoro-3-Chloro-5-Bromopyridine 38185-56-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Fluoro-3-Chloro-5-Bromopyridine 38185-56-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08