2-Bromo-5-fluoroanisole

Product Name: 2-Bromo-5-fluoroanisole
CAS No.: 450-88-4
Chemical Name: 2-Bromo-5-fluoroanisole
Synonyms: BUTTPARK 87\07-62;2-BROMO-5-FLUOROANISOLE;2-Bromo-5-fluoroanisole >2-Bromo-5-fluoroanisole98+%;2-bromo-5-fluorobenzane ether;2-methoxy-4-fluorobromobenzene;1-Bromo-4-fluoro-2-methoxybenzene;2-BroMo-5-fluoroanisole, 95.0%(GC);Benzene, 1-bromo-4-fluoro-2-methoxy-;2-Bromo-5-fluoroanisole ISO 9001：2015 REACH
CBNumber: CB0745262
Molecular Formula: C7H6BrFO
Formula Weight: 205.02
MOL File: 450-88-4.mol

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2-Bromo-5-fluoroanisole Property

Boiling point:: 143-145 °C
Density: 1.5983
refractive index: 1.542
Flash point:: 90 °C
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
color: Colorless to Light yellow
InChIKey: KGYXKRGMSUHYCY-UHFFFAOYSA-N
CAS DataBase Reference: 450-88-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-36-22
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Harmful
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 682543
Product name: 2-Bromo-5-fluoroanisole
Purity: 99%
Packaging: 5g
Price: $179
Updated: 2022/05/15

TCI Chemical

Product number: B3875
Product name: 2-Bromo-5-fluoroanisole
Purity: >95.0%(GC)
Packaging: 5g
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: B3875
Product name: 2-Bromo-5-fluoroanisole
Purity: >95.0%(GC)
Packaging: 25g
Price: $442
Updated: 2025/07/31

TRC

Product number: B691890
Product name: 2-Bromo-5-fluoroanisole
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105377
Product name: 1-Bromo-4-fluoro-2-methoxybenzene
Packaging: 25g
Price: $110
Updated: 2021/12/16

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2-Bromo-5-fluoroanisole Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid to pale yellow liquid

Uses

2-Bromo-5-fluoroanisole is a halogenated anisole compound, the chemical reactivity of which is mainly concentrated on the bromine atom on its benzene ring. It can be used as an organic synthesis intermediate and a synthetic raw material for drug molecules. For example, literature reports that the substance can be used for the preparation of the drug molecule anacetrapib.

Synthesis

77-78-1

147460-41-1

450-88-4

a) A suspension of 2-bromo-5-fluorophenol (20.0 g, 104.7 mmol) and potassium carbonate (21.71 g, 157.1 mmol) was formed in acetone (200 mL). To this suspension dimethyl sulfate (10.90 mL, 115.2 mmol) was slowly added. The reaction mixture was stirred at 60 °C for 2 h. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in a mixture of ether (200 mL) and water (100 mL) to separate the organic phase. The organic phase was washed sequentially with 2N aqueous hydrochloric acid (50 mL) and saturated sodium bicarbonate solution (50 mL), and then dried with anhydrous magnesium sulfate. The dried organic phase was evaporated from the solvent under reduced pressure to give the light yellow oily product 2-bromo-5-fluoroanisole (21.46 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 7.45 (1H, dd, Ar-H), 6.70-6.55 (2H, m, Ar-H), 3.90 (3H, s, OCH3).

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 29
[2] Patent: WO2004/43903, 2004, A1. Location in patent: Page 30
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 28

2-Bromo-5-fluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluoroanisole Suppliers

Americas 1 Belgium 1 China 189 Europe 1 France 1 Germany 5 India 6 Italy 1 Japan 1 The Netherlands 1 United Kingdom 15 United States 35 Global 257

J & K SCIENTIFIC LTD.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from 2-Bromo-5-fluoroanisole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-5-fluoroanisole 450-88-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Honest Joy Holdings Limited

Product: 2-Bromo-5-fluoroanisole 450-88-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-01-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Bromo-5-fluoroanisole 450-88-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

450-88-4, 2-Bromo-5-fluoroanisoleRelated Search:

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2-BroMo-5-fluoroanisole, 95.0%(GC)

1-Bromo-4-fluoro-2-methoxybenzene, 2-Bromo-5-fluorophenyl methyl ether

BUTTPARK 87\07-62

2-BROMO-5-FLUOROANISOLE

1-Bromo-4-fluoro-2-methoxybenzene

2-Bromo-5-fluoroanisole98+%

2-Bromo-5-fluoroanisole &gt

Benzene, 1-bromo-4-fluoro-2-methoxy-

2-Bromo-5-fluoroanisole ISO 9001：2015 REACH

2-methoxy-4-fluorobromobenzene

2-bromo-5-fluorobenzane ether

450-88-4

Anisole