ChemicalBook > CAS DataBase List > CHEMBRDG-BB 7959525

CHEMBRDG-BB 7959525

Product Name
CHEMBRDG-BB 7959525
CAS No.
667403-46-5
Chemical Name
CHEMBRDG-BB 7959525
Synonyms
2-(2,5-dichlorobenzamido)acetic acid;(2,5-dichlorobenzoyl)glycine;CHEMBRDG-BB 7959525;Ixazomib Impurity 10;Ixazomib Impurity 67;UKRORGSYN-BB BBV-048921;5-Dichlorobenzoyl)glycine;N-(2,5-DICHLOROBENZOYL)GLYCINE;2-(2,5-dichlorobenzoyl)glycine;5-dichlorobenzamido)acetic acid
CBNumber
CB0795560
Molecular Formula
C9H7Cl2NO3
Formula Weight
248.06
MOL File
667403-46-5.mol
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CHEMBRDG-BB 7959525 Property

Boiling point:
420.6±45.0 °C(Predicted)
Density 
1.505±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.63±0.10(Predicted)
InChI
InChI=1S/C9H7Cl2NO3/c10-5-1-2-7(11)6(3-5)9(15)12-4-8(13)14/h1-3H,4H2,(H,12,15)(H,13,14)
InChIKey
HKUAUZSWGMQPOK-UHFFFAOYSA-N
SMILES
C(O)(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D436603
Product name
N-(2,5-Dichlorobenzoyl)glycine
Packaging
5g
Price
$55
Updated
2021/12/16
Activate Scientific
Product number
AS48394
Product name
2-(2,5-Dichlorobenzamido)acetic acid
Purity
97+%
Packaging
1g
Price
$62
Updated
2021/12/16
Activate Scientific
Product number
AS48394
Product name
2-(2,5-Dichlorobenzamido)acetic acid
Purity
97+%
Packaging
5G
Price
$189
Updated
2021/12/16
AK Scientific
Product number
0019AP
Product name
N-(2,5-Dichlorobenzoyl)glycine
Packaging
10g
Price
$320
Updated
2021/12/16
AK Scientific
Product number
J91937
Product name
N-(2,5-Dichlorobenzoyl)glycine
Packaging
25g
Price
$450
Updated
2021/12/16
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CHEMBRDG-BB 7959525 Chemical Properties,Usage,Production

Uses

N-(2,5-Dichlorobenzoyl)glycine is an amino acid derivative.

Synthesis

56-40-6

2905-61-5

667403-46-5

Example 1: Synthesis of N-(2,5-dichlorobenzoyl)glycine Step I: Preparation of N-(2,5-dichlorobenzoyl)glycine To a solution of water (120 mL) containing NaOH (12 g, 300 mmol) and glycine (18 g, 239 mmol), a solution of THF (15 mL) with 2,5-dichlorobenzoyl chloride (10 g, 48 mmol) was added dropwise over a 45-minute period, and the temperature of the reaction was controlled to be lower than 25 °C. After the dropwise addition, stirring was continued for 1 hour. Subsequently, the reaction mixture was acidified with 2.0 M HCl (125 mL), controlling the temperature below 5 °C. The precipitate was collected by vacuum filtration and the crude product was recrystallized from water to give N-(2,5-dichlorobenzoyl)glycine as a white crystalline solid (6.1 g, 52% yield). Melting point 173.3°C. 1H NMR (300MHz, DMSO-d6, δ): 12.72 (bs, 1H), 8.89 (t, J = 6.0Hz, 1H), 7.54 (m, 2H), 7.48 (m, 1H), 3.93 (d, J = 6.0Hz, 2H). 13C NMR (75MHz, DMSO-d6, δ): 41.6, 129.3, 129.6, 131.4, 132.2, 138.2, 165.9, 171.4. MS (m/z): [M + H]+ calculated value C9H8Cl2NO3 248.0; measured value 248.0; [M + Na]+ calculated value C9H7Cl2NNaO3 270.0; measured value 270.2. Alternative synthesis method: To a solution of glycine (21.5 g, 286 mmol) in water (437 mL) was added 2.0 M NaOH (130 mL) and cooled to 0°C. A solution of 2,5-dichlorobenzoyl chloride (50.0 g, 239 mmol) in THF (75 mL) was added dropwise at a rate of 0 ± 10 °C at a controlled temperature. During the dropwise addition, the pH was maintained at 11.0 ± 0.2 by dropwise addition of 2.0 M NaOH using a pH controller.After the dropwise addition, stirring was continued at 0 ± 10 °C for 2 h. The pH of the solution was maintained at 11.0 ± 0.2 by dropwise addition of 2.0 M NaOH using a pH controller. Subsequently, the solution was acidified to pH 2.5 with 2.0 M HCl (176 mL), the precipitate was collected by filtration, washed with cold water (125 mL), and dried under vacuum at 45 °C to afford N-(2,5-dichlorobenzoyl)glycine as a white solid (57.6 g, 97.3% yield).

References

[1] Patent: WO2009/154737, 2009, A1. Location in patent: Page/Page column 61
[2] Patent: WO2018/173071, 2018, A1. Location in patent: Page/Page column 16

CHEMBRDG-BB 7959525 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CHEMBRDG-BB 7959525 manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
(2,5-dichlorobenzoyl)glycine 667403-46-5
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2025-05-12
Henan Fengda Chemical Co., Ltd
Product
N-(2,5-Dichlorobenzoyl)glycine 667403-46-5
Price
US $8.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-23
Career Henan Chemical Co
Product
CHEMBRDG-BB 7959525 667403-46-5
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-26

667403-46-5, CHEMBRDG-BB 7959525Related Search:

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate 4-piperidin-3-ylaniline Methyl 3-formyl-2-nitrobenzoate OTAVA-BB BB7018611136 METHYL 2-[(2,5-DICHLOROBENZOYL)AMINO]ACETATE CHEMBRDG-BB 7959525 1-(2,5-dichlorobenzoyl)pyrrolidine-2-carboxylic acid OTAVA-BB BB7018611148 OTAVA-BB BB7018611135 OTAVA-BB BB7018611138 2-[(2,5-dichlorophenyl)formamido]-3-methylbutanoic acid OTAVA-BB BB7018611147 OTAVA-BB BB7018611141 2-[(2,5-dichlorophenyl)formamido]-3-hydroxypropanoic acid 2-[(2,5-dichlorophenyl)formamido]propanoic acid 2-[(2,5-dichlorophenyl)-N-methylformamido]acetic acid OTAVA-BB BB7018611137

  • CHEMBRDG-BB 7959525
  • 2-(2,5-dichlorobenzamido)acetic acid
  • N-(2,5-DICHLOROBENZOYL)GLYCINE
  • UKRORGSYN-BB BBV-048921
  • N-(2,5-dichlorobenzoyl)glycine(SALTDATA: FREE)
  • 2-[(2,5-dichlorobenzoyl)amino]acetic acid
  • (2,5-dichlorobenzoyl)glycine
  • 5-Dichlorobenzoyl)glycine
  • N-[(2,5-dichlorophenyl)carbonyl]glycine
  • Ixazomib Impurity 10
  • 2-(2,5-dichlorobenzamido)acetic acie
  • Glycine, N-(2,5-dichlorobenzoyl)-
  • 5-dichlorobenzamido)acetic acid
  • 2-(2,5-dichlorobenzoyl)glycine
  • 2-[(2,5-dichlorobenzoyl)amino]aceticaci
  • Ixazomib Impurity 67
  • 2-(2,5-Dichlorobenzcarboxcarboxcarboxamido)-acetic acid
  • 667403-46-5