Ulocuplumab

Product Name: Ulocuplumab
CAS No.: 1375830-34-4
Chemical Name: Ulocuplumab
Synonyms: Ulocuplumab;BMS 936564|||MDX 1338;Ulocuplumab (anti-CXCR4);Research Grade Ulocuplumab;Research Grade Ulocuplumab(DHF39901)
CBNumber: CB08080897
Formula Weight: 0
MOL File: Mol file

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Ulocuplumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Ulocuplumab Chemical Properties,Usage,Production

Uses

Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models[1][2].

in vivo

Ulocuplumab (3-30 mg/kg; i.p.; every 3-4 days for 5 doses; 65 days in total) inhibits tumor growth of multiple myeloma xenograft models in mice, including Ramos B cells, HL-60 cells, MOLP-8 cells, Nomo-1 cells, and JJN-3R cells models^[1].

Animal Model:	Severe combined immunodeficient (SCID) mice of AML model (MOLP-8 cells)^[1]
Dosage:	3-30 mg/kg
Administration:	Intraperitoneal injection; every 3-4 days for 5 doses; last for 65 days
Result:	Significantly delayed mean tumor growth by 66% and 56% when compared with isotype control on day 25.

IC 50

CXCR4

References

[1] Kashyap MK, et al. Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. Oncotarget. 2016 Jan 19;7(3):2809-22. DOI:10.18632/oncotarget.6465
[2] Kuhne MR, et al. BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66. DOI:10.1158/1078-0432.CCR-12-2333

Ulocuplumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Ulocuplumab Suppliers

China 19 United States 2 Global 21

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Ulocuplumab

Research Grade Ulocuplumab(DHF39901)

Ulocuplumab (anti-CXCR4)

BMS 936564|||MDX 1338

Research Grade Ulocuplumab

1375830-34-4