Odronextamab

Product Name: Odronextamab
CAS No.: 1801338-64-6
Chemical Name: Odronextamab
Synonyms: Odronextamab;Research Grade Odronextamab;Odronextamab (anti-CD20&CD3);Research Grade Odronextamab(DHC90715)
CBNumber: CB08081182
Formula Weight: 0
MOL File: Mol file

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Odronextamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Odronextamab Chemical Properties,Usage,Production

Uses

Odronextamab is a stable humanized IgG4 CD20?×?CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research[1].

in vivo

Odronextamab (0.4-1 mg/kg, administered via intraperitoneal injection, single dose) exhibits dose-dependent tumor-suppressive activity in a mouse tumor model^[2].

Animal Model:	Raji cell xenograft tumor mice model^[2]
Dosage:	0.04, 0.1, 0.4, 1.0 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Treatment at doses of 0.4 or 1 mg/kg in mice resulted in complete tumor suppression. In mice receiving 0.04-0.1 mg/kg concentrations of odronextamab, tumor growth was slowed.

References

[1] Rajat Bannerji, et al. Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial. Lancet H DOI:10.1016/S2352-3026(22)00072-2
[2] Zhu M, et al. Translational findings for odronextamab: From preclinical research to a first-in-human study in patients with CD20+ B-cell malignancies. Clin Transl Sci. 2022 Apr;15(4):954-966. DOI:10.1111/cts.13212

Odronextamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Odronextamab Suppliers

China 13 United States 1 Global 14

Shanghai YuanYe Biotechnology Co., Ltd.

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Biolab Reagents

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Atagenix Laboratories

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AntibodySystem Laboratories SAS

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Selleck Chemicals

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Cell Sciences

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Biorbyt Ltd.

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Odronextamab

Research Grade Odronextamab(DHC90715)

Research Grade Odronextamab

Odronextamab (anti-CD20&CD3)

1801338-64-6