Nalmefene hydrochloride

Product Name: Nalmefene hydrochloride
CAS No.: 58895-64-0
Chemical Name: Nalmefene hydrochloride
Synonyms: Revex;NALMEFENE HCL;Unii-K7K69qc05x;Nalmefene Impurity 2;nalmefene hydrochloride;Nalmefene Hydrochloride IMP;Nalmefene Hydrochloride Impurity;(5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride;17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
CBNumber: CB0855103
Molecular Formula: C21H26ClNO3
Formula Weight: 375.89
MOL File: 58895-64-0.mol

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Nalmefene hydrochloride Property

Melting point:: 180-185°
storage temp.: Desiccate at RT
solubility: Soluble in Water (up to 25 mg/ml).
form: solid
pka: 7.63(at 25℃)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
CAS DataBase Reference: 58895-64-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 4085
Product name: Nalmefenehydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $118
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009358
Product name: NALMEFENE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1MG
Price: $400.43
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009358
Product name: NALMEFENE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $402.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009358
Product name: NALMEFENE HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $404.35
Updated: 2021/12/16

Crysdot

Product number: CD31001381
Product name: NalmefeneHydrochloride
Purity: 98%
Packaging: 250mg
Price: $160
Updated: 2021/12/16

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Nalmefene hydrochloride Chemical Properties,Usage,Production

Description

Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.

Originator

IVAX (U.S.A.)

Uses

Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist

brand name

Revex

storage

Desiccate at RT

References

1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624 2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588 3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154 4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence – a critical review; Curr. Drug Abuse Rev., 1 280

Nalmefene hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nalmefene hydrochloride Suppliers

China 109 Europe 2 Germany 1 India 7 The Netherlands 1 United Kingdom 4 United States 16 Global 140

LGM Pharma

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View Lastest Price from Nalmefene hydrochloride manufacturers

Longyan Tianhua Biological Technology Co., Ltd

Product: Nalmefene hydrochloride 58895-64-0
Price: US $35.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-14

Career Henan Chemical Co

Product: Nalmefene hydrochloride 58895-64-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

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Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, (5alpha)-

Revex

Unii-K7K69qc05x

(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride

(5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol

Morphinan-3,14-diol,17-(cyclopropylMethyl)-4,5-epoxy-6-Methylene-, hydrochloride (1:1), (5a)-

(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol,hydrochloride

Nalmefene Impurity 2

(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylene-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol hydrochloride

17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride

nalmefene hydrochloride

NALMEFENE HCL

Nalmefene Hydrochloride Impurity

Nalmefene Hydrochloride IMP

58895-64-0

55895-64-0

C21H25NO3HC

C21H25NO3HCl

Inhibitors

58895-64-0