Ursonic acid
- Product Name
- Ursonic acid
- CAS No.
- 6246-46-4
- Chemical Name
- Ursonic acid
- Synonyms
- 3-Ketone;CCRIS 7123;TOS-BB-0966;Ursomic acid;URSONIC ACID;Arbutin acid;Ursonic acid, >98%;3-Ketoursolic acid;3-Oxours-12-en-28-oicaci;3-oxours-12-en-28-oic acid
- CBNumber
- CB0855178
- Molecular Formula
- C30H46O3
- Formula Weight
- 454.68
- MOL File
- 6246-46-4.mol
Ursonic acid Property
- Melting point:
- 284-285 °C
- Boiling point:
- 555.1±50.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 10 mg/mL (21.99 mM; Need ultrasonic and warming)
- form
- powder to crystal
- pka
- 4.68±0.70(Predicted)
- color
- White to Almost white
- InChIKey
- MUCRYNWJQNHDJH-OADIDDRXSA-N
- SMILES
- C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3(C(=CC1)[C@]1([C@@](CC[C@H]([C@@H]1C)C)(C(O)=O)CC3)[H])C)(C)CC2)[H])(C)C
- CAS DataBase Reference
- 6246-46-4
Safety
- HS Code
- 2918.30.9000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- O0508
- Product name
- 3-Oxours-12-en-28-oic Acid
- Packaging
- 100MG
- Price
- $181
- Updated
- 2024/03/01
- Product number
- 299823
- Product name
- 3-oxo-urs-12-en-28-oic acid
- Packaging
- 10mg
- Price
- $546
- Updated
- 2021/12/16
- Product number
- 098522
- Product name
- 3-Oxours-12-en-28-oic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $565
- Updated
- 2021/12/16
- Product number
- W2620
- Product name
- Ursonicacid
- Packaging
- 1g
- Price
- $812
- Updated
- 2021/12/16
- Product number
- SHG0005740
- Product name
- 3-OXOURS-12-EN-28-OIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575
- Updated
- 2021/12/16
Ursonic acid Chemical Properties,Usage,Production
Chemical Properties
Ursonic acid (UNA; 3-Oxo-urs-12-en-28-oic acid) is a polycyclic triterpenoid. As the polarity of UNA is also low, ethanol and methanol, which are less polar than water, can dissolve UNA. Ursolic acid (ULA) and UNA commonly belong to ursane-type triterpenoids, and their basic structures are characterized by five rings, a double bond between C-12 and C-13, and a carboxyl group at the C-28 position. Both ULA and UNA hold three oxygen atoms, which can activate ligands and donate lone electron pairs to transition metals. The carboxyl group at the C-28 position significantly enhances the pharmacological potency of triterpenoids. The structure of UNA is quite similar to that of ULA, with UNA possessing a keto group at the C-3 position instead of the β-hydroxy group found in ULA. This difference in the C-3 position may explain the dissimilar biological activities of the two compounds[1].
Occurrence
Ursonic acid (UNA) can be found in several parts of various plants used in traditional herbal medicines. According to previous studies, UNA can be extracted from Crataegus pinnatifida and Malus baccata fruits. In particular, UNA is one of the primary compounds present in the ripened fruits of Ziziphus jujuba. It was reported that resins from Pistacia atlantica, Bursera delpechiana, and trees of the Dipterocarpaceae family contain triterpenoids, including UNA. UNA is also found in the roots of Toona sinensis, Piper betle, and Ficus microcarpa. Extraction of aerial parts of Lantana camara, which was traditionally used for the treatment of eczema, ulcers, rheumatism, and malaria, also resulted in the isolation of UNA. It is known that UNA can be obtained from the leaves of Lantana tiliaefolia and Rauvolfia vomitoria. Furthermore, UNA was isolated from a whole Catharanthus Roseus and Dracocephalum komarovi plant, which are widely used as folk medicines in Asia, Europe, and Africa. This extensive presence of UNA in medicinal herbs suggests that UNA itself can exert therapeutic potential against diseases such as cancer and infectious protozoa[1].
References
[1] Juhyeon Son, Sang Yeol Lee. “Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid.” Biomolecules (2020).
Uses
Ursonic acid (UNA) is a phytochemical which can be also extracted from a great variety of traditional medicinal herbs. It can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents. Ursonic acid induces the apoptosis of human cancer cells through multiple signaling pathways.
Definition
ChEBI: Ursonic acid is a triterpenoid. It is a natural product found in Bursera linanoe, Lantana camara, and other organisms with data available.
Biological Activity
Ursonic acid is a natural triterpene acid that can induce apoptosis in human cancer cells through various signaling pathways.
Synthesis
3-oxo-12-en-28-ursolic acid (2) was obtained after compound 1 was refluxed in acetone under the action of Jones reagent for 5 hours, and then a series of anti-tumor Active novel quinoline oxadiazole derivatives.
target
| Human Endogenous Metabolite < span> |
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View Lastest Price from Ursonic acid manufacturers
- Product
- 3-Oxours-12-en-28-oic acid 6246-46-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- HPLC≥98%
- Supply Ability
- 100kg
- Release date
- 2024-03-14
- Product
- 3-Oxours-12-en-28-oic acid 6246-46-4
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 100 g
- Release date
- 2020-08-13
- Product
- 3-oxo-urs-12-en-28-oic acid 6246-46-4 6246-46-4
- Price
- US $40.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-18