4-Bromo-2,6-di-tert-butylanisole
- Product Name
- 4-Bromo-2,6-di-tert-butylanisole
- CAS No.
- 1516-96-7
- Chemical Name
- 4-Bromo-2,6-di-tert-butylanisole
- Synonyms
- 5-BroMo-1,3-di-tert-butyl-2-Methoxybenzene;-2-methoxybenzene;5-Bromo-1,3-di-tert-butyL;4-BroMo-2,6-di-t-butylanisole;4-Bromo-2,6-di-tert-butylanisole;3,5-di-tert-butyl-4-methoxybromobenzene;1-bromo-3,5-di-tert-butyl-4-methoxybenzene;1-Bromo-4-methoxy-3,5-di-tert-butylbenzene;Benzene, 5-bromo-1,3-bis(1,1-dimethylethyl)-2-methoxy-
- CBNumber
- CB0855532
- Molecular Formula
- C15H23BrO
- Formula Weight
- 299.25
- MOL File
- 1516-96-7.mol
4-Bromo-2,6-di-tert-butylanisole Property
- Melting point:
- 49-50°C
- Boiling point:
- 304°C
- Density
- 1.137
- Flash point:
- 128°C
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C15H23BrO/c1-14(2,3)11-8-10(16)9-12(13(11)17-7)15(4,5)6/h8-9H,1-7H3
- InChIKey
- KKHJQLVAMOKQHO-UHFFFAOYSA-N
- SMILES
- C1(C(C)(C)C)=CC(Br)=CC(C(C)(C)C)=C1OC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B685633
- Product name
- 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B685633
- Product name
- 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J96352
- Product name
- 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- J96352
- Product name
- 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB140451
- Product name
- 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene
- Packaging
- 1g
- Price
- $206
- Updated
- 2021/12/16
4-Bromo-2,6-di-tert-butylanisole Chemical Properties,Usage,Production
Synthesis
1139-52-2
77-78-1
1516-96-7
The general procedure for the synthesis of 4-bromo-2,6-di-tert-butyl anisole from 4-bromo-2,6-di-tert-butylphenol and dimethyl sulfate was as follows: 4-bromo-2,6-di-tert-butylphenol (50 g, 0.175 mol) and potassium carbonate (96.7 g, 4.0 eq.) were dissolved in acetone (750 mL) under argon atmosphere protection. Dimethyl sulfate (38.6 g, 1.75 eq.) was slowly added to the reaction system at 22 °C, followed by heating the reaction mixture to reflux and stirring for 13 hours. After completion of the reaction, the insoluble material was removed by filtration and the solvent was evaporated under reduced pressure. A partition extraction was performed by adding ethyl acetate (150 mL) and water (100 mL) to the residue. The organic layer was washed sequentially with water (100 mL), 5% aqueous NaHCO3 (100 mL) and 5% aqueous NaCl (100 mL). The organic layer was dried with anhydrous magnesium sulfate, and after filtration by gravity, the filtrate was concentrated under reduced pressure to afford 4-bromo-2,6-di-tert-butylanisole (56.1 g, brown oil) in 95.2% yield. The product was analyzed by 1H-NMR (300 MHz, CDCl3, TMS) with chemical shifts of δ 1.41 (s, 18H), 3.68 (s, 3H), 7.33 (s, 2H).
References
[1] Journal of the American Chemical Society, 2006, vol. 128, # 51, p. 16486 - 16487
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 33, p. 9738 - 9742
[3] Angew. Chem., 2016, vol. 128, # 33, p. 9890 - 9894,5
[4] Patent: EP1452537, 2004, A1. Location in patent: Page 27
[5] Patent: EP1568701, 2005, A1. Location in patent: Page/Page column 13
4-Bromo-2,6-di-tert-butylanisole Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2,6-di-tert-butylanisole Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0519-85386832 13382812559
- Fax
- 0519-85386832
- sales@cztrchem.com
- Country
- China
- ProdList
- 1185
- Advantage
- 56
- Tel
- 166-166-37336996 15690792173
- Fax
- 0373-7759608
- chenxi.song@runvmat.com
- Country
- China
- ProdList
- 285
- Advantage
- 55
- Tel
- 400-106-2016 17800804092
- admin@infsci.com
- Country
- China
- ProdList
- 555
- Advantage
- 55
View Lastest Price from 4-Bromo-2,6-di-tert-butylanisole manufacturers
- Product
- 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene 1516-96-7
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 4-Bromo-2,6-di-tert-butylanisole 1516-96-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 0.10000000149011612KG
- Purity
- 99%
- Supply Ability
- 50KG
- Release date
- 2022-10-26
- Product
- 4-Bromo-2,6-di-tert-butylanisole 1516-96-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09