ChemicalBook > CAS DataBase List > beta-D-Fructopyranose

beta-D-Fructopyranose

Product Name: beta-D-Fructopyranose
CAS No.: 7660-25-5
Chemical Name: beta-D-Fructopyranose
Synonyms: Fructopyranose;S(-)-FRUCTOSE;β-D-Fructopyranose;Frutabs;Levungen;Laevoral;Fructosteril;FRUCTOSE HPLC;Fructose powder;Fructose,HPLC≥96%
CBNumber: CB0875684
Molecular Formula: C6H12O6
Formula Weight: 180.16
MOL File: 7660-25-5.mol

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beta-D-Fructopyranose Property

Melting point:: 103°C
Boiling point:: 232.96°C (rough estimate)
Density: 1.6000
refractive index: 1.6170 (estimate)
storage temp.: Storage temp. 2-8°C
pka: 11.52±0.70(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1/C6H12O6/c7-2-6(11)5(10)4(9)3(8)1-12-6/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/s3
InChIKey: LKDRXBCSQODPBY-ZSYVZJKANA-N
SMILES: C([C@]1(OC[C@@H](O)[C@@H](O)[C@@H]1O)O)O |&1:1,4,6,8,r|
CAS DataBase Reference: 7660-25-5
NIST Chemistry Reference: Fructose(7660-25-5)
CAS Number Unlabeled: 57-48-7

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Safety

Hazardous Substances Data: 7660-25-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: N1503
Product name: Fructose
Packaging: 20mg
Price: $25
Updated: 2021/12/16

ChemScene

Product number: CS-8113
Product name: Fructose
Purity: ≥98.0%
Packaging: 500mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-8113
Product name: Fructose
Purity: ≥98.0%
Packaging: 1g
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-8113
Product name: Fructose
Purity: ≥98.0%
Packaging: 5g
Price: $84
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CRB0000796
Product name: BETA-D-(-)-FRUCTOSE
Purity: 95.00%
Packaging: 100G
Price: $2457.88
Updated: 2021/12/16

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beta-D-Fructopyranose Chemical Properties,Usage,Production

Chemical Properties

Fructose is also called levulose or fruit sugar, C6H12O6. It is the sweetest of the common sugars, being from 1.1 to 2.0 times as sweet as sucrose. Fructose is generally found in fruits and honey. An apple is 4% sucrose, 6% fructose, and 1% glucose (by weight). A grape (Vitis labrusca) is about 2% sucrose, 8% fructose, 7% glucose, and 2% maltose (by weight) (Shallenberger).

Uses

Fructose is a simple ketonic monosaccharide found in many plants, where it is often bonded to glucose to form the disaccharide sucrose.

Production Methods

Commercially processed fructose is available as white crystals, soluble in water, alcohol, and ether, with a melting point between 103 and 105 °C (217.4 and 221 °F) (decomposition). Fructose can be derived by the hydrolysis of inulin; by the hydrolysis of beet sugar followed by lime separation; and from cornstarch by enzymic or microbial action.

Definition

ChEBI: Beta-D-fructopyranose is a D-fructopyranose in which the anomeric centre has beta-configuration. It is an enantiomer of a beta-L-fructopyranose.

in vivo

Fructose can be used in animal modeling to create rat models of hyperuricemia and diabetes. In mice fed a 0% Fructose diet, portal vein (0.060±0.006 mM, overall average across all time points) and systemic (0.030±0.003 mM) Fructose concentrations do not change over time after feeding. In contrast, in wild-type mice, the portal vein concentration more than doubles from time (t)=0 to t=1 hour post-feeding (~0.13 mM). Similarly, systemic serum Fructose increases from 0.037 at t=0 to 0.13 mM one hour post-feeding. In the 20% group, fasting (t=0) serum Fructose levels in the portal vein and systemically are similar to the postprandial concentrations in 0% mice, suggesting that baseline Fructose concentrations during fasting are not affected by diet. At the same dietary conditions, time, and sampling site, serum Fructose concentrations in KHK^-/- mice are 5 to 100 times higher than in wild-type mice. The mean (across all time points) portal vein and systemic glucose concentrations in mice fed 20% Fructose are approximately 3 (P=0.004) and 2 (P=0.04) mM higher, respectively, compared to mice fed 0% Fructose. Systemic Fructose concentrations in KHK^-/- mice fed 20% Fructose are about three times higher than in mice fed glucose, whereas systemic Fructose concentrations in wild-type mice fed Fructose are similar to those fed glucose^[2].

Induces high uric acid^[3]

Background

Fructose accelerates the synthesis of purines, increases the production of uric acid, reduces the excretion of uric acid by affecting kidney function, and also produces a large amount of reactive oxygen species, leading to oxidative stress, activating inflammatory signaling pathways and promoting uric acid production.

Specific Modeling Methods

Mice: ICR male mice ? 18-22 g
Administration: 30% Fructose in drinking water ? intragastrically ? for six weeks

Note

(1) Mice were placed in a temperature and humidity controlled environment with a 12 h light-dark cycle^[3].
(2) Fresh drinking water was replaced every 2 days^[3].
(3) 24 h urine volume was collected and recorded^[3].

Modeling Indicators

Molecular changes: mouse renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9) increased protein levels, ATP-binding cassette subfamily G member 2 (ABCG2) and organic anion transporter 1 (OAT1) decreased protein levels, and organic cation transporter 1 (OCT1) and OCT2 were downregulated. Increases protein levels of TLR4 and MyD88 in the kidneys. NLRP3 inflammasome is activated and IL-1β secretion is increased^[3].
Tissue changes: Infiltration of inflammatory cells in mouse glomeruli^[3].
Metabolic changes: Increase serum uric acid, creatinine, blood urea nitrogen levels, reduce urine uric acid and creatinine levels (FEUA is significantly reduced)^[3].

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Induces type 2 diabetes^[4]

Background

Fructose's metabolites induce insulin resistance, and the reactive oxygen species produced lead to oxidative stress, activate inflammatory responses and affect the action of insulin. Fructose is rapidly metabolized in the liver, resulting in excess production, leading to obesity and hyperlipidemia.

Specific Modeling Methods

Rat: Male Sprague Dawley rats ? 200-250 g
Administration: 65% fructose ? oral administration ? 8 weeks of feeding

Note

(1) At 3 and 8 weeks, blood was collected from the retroorbital plexus using small capillary tubes and serum was collected for biochemical analysis^[4].

Modeling Indicators

Molecular changes: Serum glucose, insulin, triglyceride, uric acid levels and insulin resistance were significantly increased. TBARS in liver tissue increased and GSH levels decreased^[4].

Correlated Product(s): /

Opposite Product(s): /

References

[1] Cirillo P, et al. Fructose induces prothrombotic phenotype in human endothelial cells : A new role for "added sugar" in cardio-metabolic risk. J Thromb Thrombolysis. 2015 Nov;40(4):444-51. DOI:10.1007/s11239-015-1243-1
[2] Patel C, et al. Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice. Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1;309(9):G779-90. DOI:10.1152/ajpgi.00188.2015
[3] Ying Yang, et al. Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. J Ethnopharmacol. 2015 Jul 1:169:49-59. DOI:10.1016/j.jep.2015.04.011
[4] Raju Padiya, et al. Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. Nutr Metab (Lond). 2011 Jul 27:8:53. DOI:10.1186/1743-7075-8-53

beta-D-Fructopyranose Preparation Products And Raw materials

Raw materials

Preparation Products

PALATINOSE SPINOSAD Lactulose D(-)-Fructose Spinosad D

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View Lastest Price from beta-D-Fructopyranose manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: beta-D-Fructopyranose 7660-25-5
Price: US $0.00/G
Min. Order: 10G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-14

Hebei Chuanghai Biotechnology Co., Ltd

Product: beta-D-Fructopyranose 7660-25-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Shaanxi Dideu Medichem Co. Ltd

Product: D-Fructose 7660-25-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 Tons
Release date: 2020-05-03

7660-25-5, beta-D-FructopyranoseRelated Search:

Tris(hydroxymethyl)nitromethane Lactulose 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose sulfamate Diacetonefructose SEDOHEPTULOSE ANHYDRIDE Levulinic acid D-Fructose-1,6-diphoshate calcium salt CALCIUM LEVULINATE D(-)-Fructose D-Fructose-1,6-diphosphate trisodium salt octahydrate D-FRUCTOSE 6-PHOSPHATE DISODIUM SALT 5-Aminolevulinic acid hydrochloride TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 2,3-Desisopropylidene Topiramate 2,3:4,5-DI-O-ISOPROPYLIDENE-B-D-FRUCTOPYRANOSE-D12 TOPIRAMATE-D12 2-CHLOROETHYL B-D-FRUCTOPYRANOSIDE Hydroxymethyl

beta-D-fructopyranose

Fructopyranose

FRUCTOSE HPLC

Fructosteril

Frutabs

Laevoral

Levungen

(2R,3S,4R,5R)-2-methyloltetrahydropyran-2,3,4,5-tetrol

FRUCTOPYRANOSE,BETA-D-

(2R,3S,4R,5R)-2-(Hydroxymethyl)oxane-2,3,4,5-tetrol

S(-)-FRUCTOSE

Engelite net impurities 25

Empagliflozin impurity 69

Fructose,HPLC≥96%

beta-D-Fructopyranose USP/EP/BP

β-D-Fructopyranose

2-(hydroxymethyl) tetrahydro-2H-pyran-2,3,4,5-tetraol

BRL 15573 dihydrochloride

D-FRUCTOSE(5-D, 95-98%)

Fructose powder

(2R,3S,4R,5R)-2-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Fructose, 10 mM in DMSO

Lactulose impurity D(EP)

7660-25-5

chemical reagent

pharmaceutical intermediate

phytochemical

Inhibitors

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract